MURA vs. VYNE

Last updated Apr 2, 2026

Compare and contrast key facts about Mural Oncology plc (MURA) and VYNE Therapeutics Inc. (VYNE).

Performance

MURA vs. VYNE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Mural Oncology plc (MURA) and VYNE Therapeutics Inc. (VYNE). The values are adjusted to include any dividend payments, if applicable.

MURA vs. VYNE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
MURA Mural Oncology plc	0.00%	-36.65%	-45.61%	55.79%
VYNE VYNE Therapeutics Inc.	4.46%	-82.68%	43.78%	-41.46%

Fundamentals

Market Cap MURA : $35.34M VYNE : $25.92M
EPS MURA : -$6.89 VYNE : -$0.62
PB Ratio MURA : 0.64 VYNE : 0.93
Total Revenue (TTM) MURA : $0.00 VYNE : $570.00K
Gross Profit (TTM) MURA : -$1.10M VYNE : $0.00
EBITDA (TTM) MURA : -$118.31M VYNE : -$28.33M

Returns By Period

MURA

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: -1.45%
• 1Y: 64.52%
• 3Y*: —
• 5Y*: —
• 10Y*: —

VYNE

• 1D: 1.42%
• 1M: 0.17%
• YTD: 4.46%
• 6M: 78.76%
• 1Y: -60.39%
• 3Y*: -41.84%
• 5Y*: -65.53%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

MURA vs. VYNE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MURA

MURA Risk / Return Rank: 59
MURA Sharpe Ratio Rank: 59
MURA Sortino Ratio Rank: 96
MURA Omega Ratio Rank: 98
MURA Calmar Ratio Rank: 19
MURA Martin Ratio Rank: 22

VYNE

VYNE Risk / Return Rank: 24
VYNE Sharpe Ratio Rank: 19
VYNE Sortino Ratio Rank: 31
VYNE Omega Ratio Rank: 31
VYNE Calmar Ratio Rank: 15
VYNE Martin Ratio Rank: 24

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MURA vs. VYNE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Mural Oncology plc (MURA) and VYNE Therapeutics Inc. (VYNE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MURA	VYNE	Difference
Sharpe ratio Return per unit of total volatility	0.54	-0.50	+1.04
Sortino ratio Return per unit of downside risk	3.77	0.08	+3.69
Omega ratio Gain probability vs. loss probability	1.70	1.01	+0.68
Calmar ratio Return relative to maximum drawdown	-0.62	-0.73	+0.11
Martin ratio Return relative to average drawdown	-1.00	-0.94	-0.06
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MURA vs. VYNE - Sharpe Ratio Comparison

The current MURA Sharpe Ratio is 0.54, which is higher than the VYNE Sharpe Ratio of -0.50. The chart below compares the historical Sharpe Ratios of MURA and VYNE, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	MURA	VYNE	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.54	-0.50	+1.04
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.62	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.21	-0.60	+0.39

Correlation

The correlation between MURA and VYNE is 0.18, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

MURA vs. VYNE - Dividend Comparison

Neither MURA nor VYNE has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

MURA vs. VYNE - Drawdown Comparison

The maximum MURA drawdown since its inception was -83.44%, smaller than the maximum VYNE drawdown of -99.99%. Use the drawdown chart below to compare losses from any high point for MURA and VYNE.

Drawdown Indicators

	MURA	VYNE	Difference
Max Drawdown Largest peak-to-trough decline	-83.44%	-99.99%	+16.55%
Max Drawdown (1Y) Largest decline over 1 year	-47.99%	-84.73%	+36.74%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.77%	—
Current Drawdown Current decline from peak	-66.06%	-99.98%	+33.92%
Average Drawdown Average peak-to-trough decline	-46.24%	-92.94%	+46.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	48.33%	65.48%	-17.15%

Volatility

MURA vs. VYNE - Volatility Comparison

The current volatility for Mural Oncology plc (MURA) is 0.00%, while VYNE Therapeutics Inc. (VYNE) has a volatility of 11.63%. This indicates that MURA experiences smaller price fluctuations and is considered to be less risky than VYNE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MURA	VYNE	Difference
Volatility (1M) Calculated over the trailing 1-month period	0.00%	11.63%	-11.63%
Volatility (6M) Calculated over the trailing 6-month period	31.67%	55.87%	-24.20%
Volatility (1Y) Calculated over the trailing 1-year period	155.07%	121.79%	+33.28%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	116.96%	106.06%	+10.90%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	116.96%	104.36%	+12.60%

Financials