LYFIX vs. JAGLX

Last updated Jun 24, 2026

LYFIX (AlphaCentric LifeSci Healthcare Fund) and JAGLX (Janus Henderson Global Life Sciences Fund Class T) are both Health & Biotech Equities funds. Over the past 5 years, LYFIX returned 6.33%/yr vs 8.38%/yr for JAGLX. A 0.80 correlation means they provide meaningful diversification when combined. LYFIX charges 1.40%/yr vs 0.92%/yr for JAGLX.

Performance

LYFIX vs. JAGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AlphaCentric LifeSci Healthcare Fund (LYFIX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, LYFIX achieves a 9.31% return, which is significantly higher than JAGLX's 2.40% return.

LYFIX

• 1D: 3.21%
• 1M: 6.36%
• YTD: 9.31%
• 6M: 8.56%
• 1Y: 46.30%
• 3Y*: 10.63%
• 5Y*: 6.33%
• 10Y*: —

JAGLX

• 1D: 1.85%
• 1M: 2.59%
• YTD: 2.40%
• 6M: 1.92%
• 1Y: 33.20%
• 3Y*: 12.94%
• 5Y*: 8.38%
• 10Y*: 12.23%

*Multi-year figures are annualized to reflect compound growth (CAGR)

LYFIX vs. JAGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
LYFIX AlphaCentric LifeSci Healthcare Fund	9.31%	28.22%	-0.27%	7.19%	-0.92%	-3.42%	54.83%	1.20%
JAGLX Janus Henderson Global Life Sciences Fund Class T	2.40%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	3.97%

Correlation

The correlation between LYFIX and JAGLX is 0.86, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.86
Correlation (3Y) Calculated over the trailing 3-year period	0.81
Correlation (5Y) Calculated over the trailing 5-year period	0.80
Correlation (All Time) Calculated using the full available price history since Nov 29, 2019	0.80

The correlation between LYFIX and JAGLX has been stable across timeframes, ranging from 0.80 to 0.86 - a consistent structural relationship.

Return for Risk

LYFIX vs. JAGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

LYFIX

LYFIX Risk / Return Rank: 83
LYFIX Sharpe Ratio Rank: 83
LYFIX Sortino Ratio Rank: 79
LYFIX Omega Ratio Rank: 65
LYFIX Calmar Ratio Rank: 95
LYFIX Martin Ratio Rank: 95

JAGLX

JAGLX Risk / Return Rank: 67
JAGLX Sharpe Ratio Rank: 68
JAGLX Sortino Ratio Rank: 71
JAGLX Omega Ratio Rank: 58
JAGLX Calmar Ratio Rank: 80
JAGLX Martin Ratio Rank: 58

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

LYFIX vs. JAGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AlphaCentric LifeSci Healthcare Fund (LYFIX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	LYFIX	JAGLX	Difference
Sharpe ratio: Return per unit of total volatility	2.50	2.21	+0.29
Sortino ratio: Return per unit of downside risk	3.43	3.21	+0.22
Omega ratio: Gain probability vs. loss probability	1.41	1.39	+0.02
Calmar ratio: Return relative to maximum drawdown	5.58	3.47	+2.11
Martin ratio: Return relative to average drawdown	20.30	11.03	+9.28

LYFIX vs. JAGLX - Sharpe Ratio Comparison

The current LYFIX Sharpe Ratio is 2.50, which is comparable to the JAGLX Sharpe Ratio of 2.21. The chart below compares the historical Sharpe Ratios of LYFIX and JAGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

LYFIX vs. JAGLX - Drawdown Comparison

The maximum LYFIX drawdown since its inception was -35.33%, smaller than the maximum JAGLX drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for LYFIX and JAGLX.

Drawdown Indicators

	LYFIX	JAGLX	Difference
Max Drawdown Largest peak-to-trough decline	-35.33%	-58.96%	+23.63%
Max Drawdown (1Y) Largest decline over 1 year	-8.49%	-9.71%	+1.22%
Max Drawdown (3Y) Largest decline over 3 years	-24.22%	-17.41%	-6.81%
Max Drawdown (5Y) Largest decline over 5 years	-32.21%	-22.25%	-9.96%
Max Drawdown (10Y) Largest decline over 10 years	—	-27.38%	—
Current Drawdown Current decline from peak	0.00%	-0.68%	+0.68%
Average Drawdown Average peak-to-trough decline	-9.79%	-17.40%	+7.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.33%	3.05%	-0.72%

Volatility

LYFIX vs. JAGLX - Volatility Comparison

AlphaCentric LifeSci Healthcare Fund (LYFIX) has a higher volatility of 7.42% compared to Janus Henderson Global Life Sciences Fund Class T (JAGLX) at 5.62%. This indicates that LYFIX's price experiences larger fluctuations and is considered to be riskier than JAGLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	LYFIX	JAGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.42%	5.62%	+1.80%
Volatility (6M) Calculated over the trailing 6-month period	15.27%	11.38%	+3.89%
Volatility (1Y) Calculated over the trailing 1-year period	18.97%	15.25%	+3.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.95%	16.00%	+6.95%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.44%	17.43%	+6.01%

LYFIX vs. JAGLX - Expense Ratio Comparison

LYFIX has a 1.40% expense ratio, which is higher than JAGLX's 0.92% expense ratio.

Dividends

LYFIX vs. JAGLX - Dividend Comparison

LYFIX's dividend yield for the trailing twelve months is around 1.63%, less than JAGLX's 4.42% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.42%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
LYFIX AlphaCentric LifeSci Healthcare Fund	1.63%	1.78%	2.24%	2.63%	4.43%	12.88%	2.30%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both LYFIX and JAGLX in my portfolio?

LYFIX and JAGLX have a correlation of 0.86, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, LYFIX or JAGLX?

LYFIX has higher volatility (7.42%) compared to JAGLX (5.62%). In terms of maximum drawdown, LYFIX dropped -35.33% vs JAGLX's -58.96%.

Which has better risk-adjusted returns?

LYFIX currently has the higher Sharpe Ratio (2.50 vs 2.21), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.