LXRX vs. IPSC

Last updated Jul 11, 2026

LXRX (Lexicon Pharmaceuticals, Inc.) and IPSC (Century Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, LXRX returned -11.46%/yr vs -39.43%/yr for IPSC. At a 0.30 correlation, their price movements are largely independent.

Performance

LXRX vs. IPSC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Lexicon Pharmaceuticals, Inc. (LXRX) and Century Therapeutics, Inc. (IPSC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, LXRX achieves a 93.04% return, which is significantly lower than IPSC's 126.18% return.

LXRX

• 1D: -1.33%
• 1M: 15.63%
• 6M: 89.74%
• YTD: 93.04%
• 1Y: 105.56%
• 3Y*: -1.60%
• 5Y*: -11.46%
• 10Y*: -17.31%

IPSC

• 1D: -2.60%
• 1M: -0.00%
• 6M: 15.98%
• YTD: 126.18%
• 1Y: 274.81%
• 3Y*: -8.22%
• 5Y*: -39.43%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

LXRX vs. IPSC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
LXRX Lexicon Pharmaceuticals, Inc.	93.04%	55.72%	-51.73%	-19.90%	-51.52%	-16.88%
IPSC Century Therapeutics, Inc.	126.18%	-1.50%	-69.58%	-35.28%	-67.65%	-18.67%

Correlation

The correlation between LXRX and IPSC is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.32
Correlation (5Y) Calculated over the trailing 5-year period	0.31
Correlation (All Time) Calculated using the full available price history since Jun 18, 2021	0.30

Fundamentals

Market Cap LXRX : $986.12M IPSC : $194.78M
EPS LXRX : -$0.07 IPSC : -$0.88
PB Ratio LXRX : 4.38 IPSC : 1.64
Total Revenue (TTM) LXRX : $69.64M IPSC : $0.00
Gross Profit (TTM) LXRX : $69.00M IPSC : -$9.88M
EBITDA (TTM) LXRX : -$20.38M IPSC : -$103.02M

Return for Risk

LXRX vs. IPSC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

LXRX

LXRX Risk / Return Rank: 81
LXRX Sharpe Ratio Rank: 80
LXRX Sortino Ratio Rank: 80
LXRX Omega Ratio Rank: 78
LXRX Calmar Ratio Rank: 86
LXRX Martin Ratio Rank: 82

IPSC

IPSC Risk / Return Rank: 95
IPSC Sharpe Ratio Rank: 96
IPSC Sortino Ratio Rank: 94
IPSC Omega Ratio Rank: 92
IPSC Calmar Ratio Rank: 97
IPSC Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

LXRX vs. IPSC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Lexicon Pharmaceuticals, Inc. (LXRX) and Century Therapeutics, Inc. (IPSC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	LXRX	IPSC	Difference
Sharpe ratio: Return per unit of total volatility	1.21	2.73	-1.51
Sortino ratio: Return per unit of downside risk	2.03	3.43	-1.40
Omega ratio: Gain probability vs. loss probability	1.24	1.42	-0.17
Calmar ratio: Return relative to maximum drawdown	2.85	7.19	-4.34
Martin ratio: Return relative to average drawdown	5.98	13.46	-7.48

LXRX vs. IPSC - Sharpe Ratio Comparison

The current LXRX Sharpe Ratio is 1.21, which is lower than the IPSC Sharpe Ratio of 2.73. The chart below compares the historical Sharpe Ratios of LXRX and IPSC, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

LXRX vs. IPSC - Drawdown Comparison

The maximum LXRX drawdown since its inception was -99.91%, roughly equal to the maximum IPSC drawdown of -98.78%. Use the drawdown chart below to compare losses from any high point for LXRX and IPSC.

Drawdown Indicators

	LXRX	IPSC	Difference
Max Drawdown Largest peak-to-trough decline	-99.91%	-98.78%	-1.13%
Max Drawdown (1Y) Largest decline over 1 year	-34.09%	-36.98%	+2.89%
Max Drawdown (3Y) Largest decline over 3 years	-91.83%	-92.68%	+0.85%
Max Drawdown (5Y) Largest decline over 5 years	-95.25%	-98.78%	+3.53%
Max Drawdown (10Y) Largest decline over 10 years	-98.48%	—	—
Current Drawdown Current decline from peak	-99.33%	-92.95%	-6.38%
Average Drawdown Average peak-to-trough decline	-93.29%	-80.66%	-12.63%
Ulcer Index Depth and duration of drawdowns from previous peaks	16.19%	19.73%	-3.54%

Volatility

LXRX vs. IPSC - Volatility Comparison

Lexicon Pharmaceuticals, Inc. (LXRX) has a higher volatility of 18.64% compared to Century Therapeutics, Inc. (IPSC) at 16.00%. This indicates that LXRX's price experiences larger fluctuations and is considered to be riskier than IPSC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	LXRX	IPSC	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.64%	16.00%	+2.64%
Volatility (6M) Calculated over the trailing 6-month period	59.84%	67.56%	-7.72%
Volatility (1Y) Calculated over the trailing 1-year period	80.22%	97.54%	-17.32%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	97.91%	83.32%	+14.59%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	97.33%	83.88%	+13.45%

Dividends

LXRX vs. IPSC - Dividend Comparison

Neither LXRX nor IPSC has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both LXRX and IPSC in my portfolio?

LXRX and IPSC have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, LXRX or IPSC?

LXRX has higher volatility (18.64%) compared to IPSC (16.00%). In terms of maximum drawdown, LXRX dropped -99.91% vs IPSC's -98.78%.

Which has better risk-adjusted returns?

IPSC currently has the higher Sharpe Ratio (2.73 vs 1.21), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.