JNGLX vs. RYOIX

Last updated Jun 4, 2026

JNGLX (Janus Henderson Global Life Sciences Fund) and RYOIX (Rydex Biotechnology Fund) are both Health & Biotech Equities funds. Over the past 10 years, JNGLX returned 10.28%/yr vs 8.43%/yr for RYOIX. Their correlation of 0.87 suggests significant overlap in exposure. JNGLX charges 0.80%/yr vs 1.36%/yr for RYOIX.

Performance

JNGLX vs. RYOIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Life Sciences Fund (JNGLX) and Rydex Biotechnology Fund (RYOIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JNGLX achieves a -3.59% return, which is significantly lower than RYOIX's 3.07% return. Over the past 10 years, JNGLX has outperformed RYOIX with an annualized return of 10.28%, while RYOIX has yielded a comparatively lower 8.43% annualized return.

JNGLX

• 1D: -2.62%
• 1M: -1.53%
• YTD: -3.59%
• 6M: -1.99%
• 1Y: 25.11%
• 3Y*: 9.32%
• 5Y*: 7.03%
• 10Y*: 10.28%

RYOIX

• 1D: -2.50%
• 1M: -0.87%
• YTD: 3.07%
• 6M: 1.44%
• 1Y: 37.64%
• 3Y*: 12.67%
• 5Y*: 4.98%
• 10Y*: 8.43%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JNGLX vs. RYOIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JNGLX Janus Henderson Global Life Sciences Fund	-3.59%	24.84%	3.60%	7.51%	-2.69%	6.78%	25.66%	29.20%	4.17%	22.13%
RYOIX Rydex Biotechnology Fund	3.07%	30.62%	-0.95%	6.06%	-13.04%	2.05%	21.94%	30.69%	-8.94%	29.68%

Correlation

The correlation between JNGLX and RYOIX is 0.87, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.87
Correlation (3Y) Calculated over the trailing 3-year period	0.85
Correlation (5Y) Calculated over the trailing 5-year period	0.87
Correlation (10Y) Calculated over the trailing 10-year period	0.89
Correlation (All Time) Calculated using the full available price history since Jan 5, 1999	0.87

The correlation between JNGLX and RYOIX has been stable across timeframes, ranging from 0.85 to 0.89 - a consistent structural relationship.

Return for Risk

JNGLX vs. RYOIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JNGLX

JNGLX Risk / Return Rank: 39
JNGLX Sharpe Ratio Rank: 36
JNGLX Sortino Ratio Rank: 37
JNGLX Omega Ratio Rank: 33
JNGLX Calmar Ratio Rank: 48
JNGLX Martin Ratio Rank: 39

RYOIX

RYOIX Risk / Return Rank: 62
RYOIX Sharpe Ratio Rank: 47
RYOIX Sortino Ratio Rank: 48
RYOIX Omega Ratio Rank: 40
RYOIX Calmar Ratio Rank: 90
RYOIX Martin Ratio Rank: 86

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JNGLX vs. RYOIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund (JNGLX) and Rydex Biotechnology Fund (RYOIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	JNGLX	RYOIX	Difference
Sharpe ratio: Return per unit of total volatility	1.73	2.02	-0.29
Sortino ratio: Return per unit of downside risk	2.53	2.93	-0.40
Omega ratio: Gain probability vs. loss probability	1.30	1.34	-0.04
Calmar ratio: Return relative to maximum drawdown	2.65	4.63	-1.98
Martin ratio: Return relative to average drawdown	8.47	16.65	-8.18
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

JNGLX vs. RYOIX - Sharpe Ratio Comparison

The current JNGLX Sharpe Ratio is 1.73, which is comparable to the RYOIX Sharpe Ratio of 2.02. The chart below compares the historical Sharpe Ratios of JNGLX and RYOIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	JNGLX	RYOIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.73	2.02	-0.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.45	0.24	+0.21
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.59	0.36	+0.23
Sharpe Ratio (All Time) Calculated using the full available price history	0.57	0.36	+0.21

Drawdowns

JNGLX vs. RYOIX - Drawdown Comparison

The maximum JNGLX drawdown since its inception was -59.00%, smaller than the maximum RYOIX drawdown of -74.43%. Use the drawdown chart below to compare losses from any high point for JNGLX and RYOIX.

Drawdown Indicators

	JNGLX	RYOIX	Difference
Max Drawdown Largest peak-to-trough decline	-59.00%	-74.43%	+15.43%
Max Drawdown (1Y) Largest decline over 1 year	-9.68%	-8.43%	-1.25%
Max Drawdown (3Y) Largest decline over 3 years	-21.17%	-23.47%	+2.30%
Max Drawdown (5Y) Largest decline over 5 years	-22.21%	-33.66%	+11.45%
Max Drawdown (10Y) Largest decline over 10 years	-27.37%	-33.66%	+6.29%
Current Drawdown Current decline from peak	-6.49%	-4.48%	-2.01%
Average Drawdown Average peak-to-trough decline	-17.65%	-27.64%	+9.99%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.02%	2.34%	+0.68%

Volatility

JNGLX vs. RYOIX - Volatility Comparison

The current volatility for Janus Henderson Global Life Sciences Fund (JNGLX) is 4.69%, while Rydex Biotechnology Fund (RYOIX) has a volatility of 6.58%. This indicates that JNGLX experiences smaller price fluctuations and is considered to be less risky than RYOIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JNGLX	RYOIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.69%	6.58%	-1.89%
Volatility (6M) Calculated over the trailing 6-month period	10.95%	14.84%	-3.89%
Volatility (1Y) Calculated over the trailing 1-year period	14.85%	19.35%	-4.50%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	15.85%	21.22%	-5.37%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.38%	23.23%	-5.85%

JNGLX vs. RYOIX - Expense Ratio Comparison

JNGLX has a 0.80% expense ratio, which is lower than RYOIX's 1.36% expense ratio.

Dividends

JNGLX vs. RYOIX - Dividend Comparison

JNGLX's dividend yield for the trailing twelve months is around 4.73%, less than RYOIX's 12.19% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JNGLX Janus Henderson Global Life Sciences Fund	4.73%	4.56%	5.84%	4.26%	0.25%	9.85%	7.80%	6.23%	13.32%	0.89%	0.30%	8.81%
RYOIX Rydex Biotechnology Fund	12.19%	12.57%	14.61%	0.00%	1.29%	19.39%	7.28%	8.58%	14.11%	5.38%	0.00%	1.45%

Frequently Asked Questions

Can I hold both JNGLX and RYOIX in my portfolio?

JNGLX and RYOIX have a correlation of 0.87, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JNGLX or RYOIX?

RYOIX has higher volatility (6.58%) compared to JNGLX (4.69%). In terms of maximum drawdown, JNGLX dropped -59.00% vs RYOIX's -74.43%.

Which has better risk-adjusted returns?

RYOIX currently has the higher Sharpe Ratio (2.02 vs 1.73), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.