JAGLX vs. LYFIX

Last updated Aug 5, 2026

JAGLX (Janus Henderson Global Life Sciences Fund Class T) and LYFIX (AlphaCentric LifeSci Healthcare Fund) are both Health & Biotech Equities funds. Over the past 5 years, JAGLX returned 9.07%/yr vs 9.00%/yr for LYFIX. Their 0.80 correlation means they have sometimes moved together and sometimes differently. JAGLX charges 0.92%/yr vs 1.40%/yr for LYFIX.

Performance

JAGLX vs. LYFIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Life Sciences Fund Class T (JAGLX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JAGLX achieves a 7.46% return, which is significantly lower than LYFIX's 12.01% return.

JAGLX

• 1D: -0.56%
• 1M: -3.52%
• 6M: 6.37%
• YTD: 7.46%
• 1Y: 36.82%
• 3Y*: 15.24%
• 5Y*: 9.07%
• 10Y*: 11.49%
• ALL TIME*: 11.64%

LYFIX

• 1D: -0.72%
• 1M: -6.41%
• 6M: 9.60%
• YTD: 12.01%
• 1Y: 46.53%
• 3Y*: 10.19%
• 5Y*: 9.00%
• 10Y*: —
• ALL TIME*: 13.30%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
JAGLX Janus Henderson Global Life Sciences Fund Class T	$0.00	$0.00	$0.00
LYFIX AlphaCentric LifeSci Healthcare Fund	$0.00	$0.00	$0.00

JAGLX vs. LYFIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
JAGLX Janus Henderson Global Life Sciences Fund Class T	7.46%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	3.97%
LYFIX AlphaCentric LifeSci Healthcare Fund	12.01%	28.22%	-0.27%	7.19%	-0.92%	-3.42%	54.83%	1.20%

Correlation

The correlation between JAGLX and LYFIX is 0.85, meaning they have usually moved in the same direction, including during past declines.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.85
Correlation (3Y) Balances recent behavior with more history.	0.82
Correlation (5Y) Shows whether the relationship held over a longer period.	0.80
Correlation (All Time) Calculated using the full available price history since Nov 29, 2019	0.80

The correlation between JAGLX and LYFIX has been stable across timeframes, ranging from 0.80 to 0.85 - a consistent structural relationship.

Return for Risk

JAGLX vs. LYFIX — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

JAGLX

JAGLX Risk / Return Rank: 90
JAGLX Sharpe Ratio Rank: 92
JAGLX Sortino Ratio Rank: 92
JAGLX Omega Ratio Rank: 85
JAGLX Calmar Ratio Rank: 92
JAGLX Martin Ratio Rank: 87

LYFIX

LYFIX Risk / Return Rank: 91
LYFIX Sharpe Ratio Rank: 92
LYFIX Sortino Ratio Rank: 89
LYFIX Omega Ratio Rank: 81
LYFIX Calmar Ratio Rank: 97
LYFIX Martin Ratio Rank: 96

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

JAGLX vs. LYFIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund Class T (JAGLX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JAGLX	LYFIX	Difference
Sharpe ratio: Return per unit of total volatility	2.46	2.46	0.00
Sortino ratio: Return per unit of downside risk	3.56	3.34	+0.22
Omega ratio: Gain probability vs. loss probability	1.42	1.40	+0.02
Calmar ratio: Return relative to maximum drawdown	3.98	5.72	-1.74
Martin ratio: Return relative to average drawdown	12.34	17.85	-5.50

JAGLX vs. LYFIX - Sharpe Ratio Comparison

The current JAGLX Sharpe Ratio is 2.46, which is comparable to the LYFIX Sharpe Ratio of 2.46. The chart below compares the historical Sharpe Ratios of JAGLX and LYFIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JAGLX vs. LYFIX - Drawdown Comparison

The maximum JAGLX drawdown since its inception was -58.96%, which is greater than LYFIX's maximum drawdown of -35.33%. Use the drawdown chart below to compare losses from any high point for JAGLX and LYFIX.

Drawdown Indicators

	JAGLX	LYFIX	Difference
Max Drawdown Largest peak-to-trough decline	-58.96%	-35.33%	-23.63%
Max Drawdown (1Y) Largest decline over 1 year	-9.71%	-8.49%	-1.22%
Max Drawdown (3Y) Largest decline over 3 years	-17.41%	-22.78%	+5.37%
Max Drawdown (5Y) Largest decline over 5 years	-22.25%	-30.46%	+8.21%
Max Drawdown (10Y) Largest decline over 10 years	-27.38%	—	—
Current Drawdown Current decline from peak	-4.30%	-8.48%	+4.18%
Average Drawdown Average peak-to-trough decline	-17.34%	-9.68%	-7.66%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.12%	2.72%	+0.40%

Volatility

JAGLX vs. LYFIX - Volatility Comparison

The current volatility for Janus Henderson Global Life Sciences Fund Class T (JAGLX) is 4.55%, while AlphaCentric LifeSci Healthcare Fund (LYFIX) has a volatility of 6.29%. This indicates that JAGLX experiences smaller price fluctuations and is considered to be less risky than LYFIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JAGLX	LYFIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.55%	6.29%	-1.74%
Volatility (6M) Calculated over the trailing 6-month period	12.37%	15.68%	-3.31%
Volatility (1Y) Calculated over the trailing 1-year period	15.75%	19.79%	-4.04%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.18%	22.91%	-6.73%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.41%	23.41%	-6.00%

JAGLX vs. LYFIX - Expense Ratio Comparison

JAGLX has a 0.92% expense ratio, which is lower than LYFIX's 1.40% expense ratio.

Dividends

JAGLX vs. LYFIX - Dividend Comparison

JAGLX's dividend yield for the trailing twelve months is around 4.21%, more than LYFIX's 1.59% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.21%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
LYFIX AlphaCentric LifeSci Healthcare Fund	1.59%	1.78%	2.24%	2.63%	4.43%	12.88%	2.30%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both JAGLX and LYFIX in my portfolio?

JAGLX and LYFIX have a correlation of 0.85, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JAGLX or LYFIX?

LYFIX has higher volatility (6.29%) compared to JAGLX (4.55%). In terms of maximum drawdown, JAGLX dropped -58.96% vs LYFIX's -35.33%.

Which has better risk-adjusted returns?

LYFIX currently has the higher Sharpe Ratio (2.46 vs 2.46), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.