IOBT vs. PSTV

Last updated Jun 4, 2026

IOBT (IO Biotech, Inc.) and PSTV (Plus Therapeutics Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. At a 0.10 correlation, their price movements are largely independent.

Performance

IOBT vs. PSTV - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in IO Biotech, Inc. (IOBT) and Plus Therapeutics Inc (PSTV). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

IOBT

• 1D: —
• 1M: —
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

PSTV

• 1D: -0.91%
• 1M: -13.97%
• YTD: -57.68%
• 6M: -63.67%
• 1Y: -42.78%
• 3Y*: -61.93%
• 5Y*: -64.92%
• 10Y*: -67.94%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IOBT vs. PSTV - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IOBT IO Biotech, Inc.	-92.12%	-33.82%	-51.06%	-18.26%	-64.06%	-59.11%
PSTV Plus Therapeutics Inc	-57.68%	-55.45%	-34.29%	-63.19%	-69.81%	-42.31%

Correlation

The correlation between IOBT and PSTV is 0.20, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.20
Correlation (3Y) Calculated over the trailing 3-year period	0.11
Correlation (All Time) Calculated using the full available price history since Nov 8, 2021	0.10

The correlation between IOBT and PSTV shifts across timeframes, from 0.10 (all time) to 0.20 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap IOBT : $3.21M PSTV : $36.02M
EPS IOBT : -$1.33 PSTV : -$4.87
PB Ratio IOBT : 3.53 PSTV : 3.01
Total Revenue (TTM) IOBT : $0.00 PSTV : $4.15M
Gross Profit (TTM) IOBT : -$910.00K PSTV : $3.89M
EBITDA (TTM) IOBT : -$87.26M PSTV : -$1.39M

Return for Risk

IOBT vs. PSTV — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PSTV

PSTV Risk / Return Rank: 33
PSTV Sharpe Ratio Rank: 29
PSTV Sortino Ratio Rank: 45
PSTV Omega Ratio Rank: 44
PSTV Calmar Ratio Rank: 24
PSTV Martin Ratio Rank: 25

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IOBT vs. PSTV - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for IO Biotech, Inc. (IOBT) and Plus Therapeutics Inc (PSTV). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	IOBT	PSTV	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	-0.28	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.33	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.37	—
Sharpe Ratio (All Time) Calculated using the full available price history	—	-0.35	—

Drawdowns

Drawdown Indicators

	IOBT	PSTV	Difference
Max Drawdown Largest peak-to-trough decline	—	-100.00%	—
Max Drawdown (1Y) Largest decline over 1 year	—	-86.87%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-97.01%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-99.73%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-100.00%	—
Current Drawdown Current decline from peak	—	-100.00%	—
Average Drawdown Average peak-to-trough decline	—	-79.49%	—
Ulcer Index Depth and duration of drawdowns from previous peaks	—	50.97%	—

Volatility

Volatility by Period

	IOBT	PSTV	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	23.53%	—
Volatility (6M) Calculated over the trailing 6-month period	—	88.41%	—
Volatility (1Y) Calculated over the trailing 1-year period	—	154.50%	—
Volatility (5Y) Calculated over the trailing 5-year period, annualized	—	198.00%	—
Volatility (10Y) Calculated over the trailing 10-year period, annualized	—	184.20%	—

Dividends

IOBT vs. PSTV - Dividend Comparison

Neither IOBT nor PSTV has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IOBT and PSTV in my portfolio?

IOBT and PSTV have a correlation of 0.20, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.