IOBT vs. PSTV

Last updated Apr 1, 2026

Compare and contrast key facts about IO Biotech, Inc. (IOBT) and Plus Therapeutics Inc (PSTV).

Performance

IOBT vs. PSTV - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in IO Biotech, Inc. (IOBT) and Plus Therapeutics Inc (PSTV). The values are adjusted to include any dividend payments, if applicable.

IOBT vs. PSTV - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IOBT IO Biotech, Inc.	-90.36%	-33.82%	-51.06%	-18.26%	-64.06%	-59.11%
PSTV Plus Therapeutics Inc	-68.26%	-55.45%	-34.29%	-63.19%	-69.81%	-42.31%

Fundamentals

Market Cap IOBT : $3.93M PSTV : $12.65B
EPS IOBT : -$1.33 PSTV : -$0.00
PB Ratio IOBT : 4.31 PSTV : 3.17K
Total Revenue (TTM) IOBT : $0.00 PSTV : $0.00
Gross Profit (TTM) IOBT : -$910.00K PSTV : $0.00
EBITDA (TTM) IOBT : -$87.26M PSTV : $0.00

Returns By Period

In the year-to-date period, IOBT achieves a -90.36% return, which is significantly lower than PSTV's -68.26% return.

IOBT

• 1D: -65.95%
• 1M: -83.18%
• YTD: -90.36%
• 6M: -83.83%
• 1Y: -94.61%
• 3Y*: -68.48%
• 5Y*: —
• 10Y*: —

PSTV

• 1D: -24.23%
• 1M: -46.28%
• YTD: -68.26%
• 6M: -76.22%
• 1Y: -82.89%
• 3Y*: -66.56%
• 5Y*: -66.21%
• 10Y*: -69.69%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

IOBT vs. PSTV — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IOBT

IOBT Risk / Return Rank: 18
IOBT Sharpe Ratio Rank: 22
IOBT Sortino Ratio Rank: 28
IOBT Omega Ratio Rank: 28
IOBT Calmar Ratio Rank: 3
IOBT Martin Ratio Rank: 5

PSTV

PSTV Risk / Return Rank: 13
PSTV Sharpe Ratio Rank: 19
PSTV Sortino Ratio Rank: 19
PSTV Omega Ratio Rank: 20
PSTV Calmar Ratio Rank: 0
PSTV Martin Ratio Rank: 8

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IOBT vs. PSTV - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for IO Biotech, Inc. (IOBT) and Plus Therapeutics Inc (PSTV). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IOBT	PSTV	Difference
Sharpe ratio Return per unit of total volatility	-0.42	-0.51	+0.09
Sortino ratio Return per unit of downside risk	-0.04	-0.48	+0.44
Omega ratio Gain probability vs. loss probability	0.99	0.94	+0.05
Calmar ratio Return relative to maximum drawdown	-0.97	-1.02	+0.05
Martin ratio Return relative to average drawdown	-1.67	-1.55	-0.12
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IOBT vs. PSTV - Sharpe Ratio Comparison

The current IOBT Sharpe Ratio is -0.42, which is comparable to the PSTV Sharpe Ratio of -0.51. The chart below compares the historical Sharpe Ratios of IOBT and PSTV, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	IOBT	PSTV	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.42	-0.51	+0.09
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.34	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.38	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.53	-0.35	-0.18

Correlation

The correlation between IOBT and PSTV is 0.10, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

IOBT vs. PSTV - Dividend Comparison

Neither IOBT nor PSTV has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

IOBT vs. PSTV - Drawdown Comparison

The maximum IOBT drawdown since its inception was -99.62%, roughly equal to the maximum PSTV drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for IOBT and PSTV.

Drawdown Indicators

	IOBT	PSTV	Difference
Max Drawdown Largest peak-to-trough decline	-99.62%	-100.00%	+0.38%
Max Drawdown (1Y) Largest decline over 1 year	-97.55%	-84.06%	-13.49%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.62%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-100.00%	—
Current Drawdown Current decline from peak	-99.62%	-100.00%	+0.38%
Average Drawdown Average peak-to-trough decline	-84.57%	-79.35%	-5.22%
Ulcer Index Depth and duration of drawdowns from previous peaks	56.99%	55.56%	+1.43%

Volatility

IOBT vs. PSTV - Volatility Comparison

IO Biotech, Inc. (IOBT) has a higher volatility of 109.77% compared to Plus Therapeutics Inc (PSTV) at 34.29%. This indicates that IOBT's price experiences larger fluctuations and is considered to be riskier than PSTV based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IOBT	PSTV	Difference
Volatility (1M) Calculated over the trailing 1-month period	109.77%	34.29%	+75.48%
Volatility (6M) Calculated over the trailing 6-month period	190.41%	83.69%	+106.72%
Volatility (1Y) Calculated over the trailing 1-year period	227.25%	164.00%	+63.25%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	135.59%	197.12%	-61.53%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	135.59%	184.35%	-48.76%

Financials