PSTV vs. TNYA

Last updated Jun 3, 2026

PSTV (Plus Therapeutics Inc) and TNYA (Tenaya Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, PSTV returned -61.82%/yr vs -53.06%/yr for TNYA. At a 0.17 correlation, their price movements are largely independent.

Performance

PSTV vs. TNYA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Plus Therapeutics Inc (PSTV) and Tenaya Therapeutics, Inc. (TNYA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PSTV achieves a -57.29% return, which is significantly lower than TNYA's 11.03% return.

PSTV

• 1D: -4.04%
• 1M: -10.18%
• YTD: -57.29%
• 6M: -62.92%
• 1Y: -40.49%
• 3Y*: -61.82%
• 5Y*: -64.45%
• 10Y*: -67.91%

TNYA

• 1D: -9.20%
• 1M: 11.93%
• YTD: 11.03%
• 6M: -35.25%
• 1Y: 71.74%
• 3Y*: -53.06%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PSTV vs. TNYA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
PSTV Plus Therapeutics Inc	-57.29%	-55.45%	-34.29%	-63.19%	-69.81%	-44.74%
TNYA Tenaya Therapeutics, Inc.	11.03%	-50.24%	-55.86%	61.19%	-89.39%	23.45%

Correlation

The correlation between PSTV and TNYA is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.21
Correlation (3Y) Calculated over the trailing 3-year period	0.17
Correlation (All Time) Calculated using the full available price history since Aug 2, 2021	0.17

Fundamentals

Market Cap PSTV : $36.35M TNYA : $171.34M
EPS PSTV : -$4.87 TNYA : -$0.48
PS Ratio PSTV : 3.23 TNYA : 610.93
PB Ratio PSTV : 3.04 TNYA : 1.61
Total Revenue (TTM) PSTV : $4.15M TNYA : $225.00K
Gross Profit (TTM) PSTV : $3.89M TNYA : $0.00
EBITDA (TTM) PSTV : -$1.39M TNYA : -$78.62M

Return for Risk

PSTV vs. TNYA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PSTV

PSTV Risk / Return Rank: 36
PSTV Sharpe Ratio Rank: 30
PSTV Sortino Ratio Rank: 45
PSTV Omega Ratio Rank: 44
PSTV Calmar Ratio Rank: 32
PSTV Martin Ratio Rank: 32

TNYA

TNYA Risk / Return Rank: 62
TNYA Sharpe Ratio Rank: 61
TNYA Sortino Ratio Rank: 69
TNYA Omega Ratio Rank: 66
TNYA Calmar Ratio Rank: 60
TNYA Martin Ratio Rank: 56

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PSTV vs. TNYA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Plus Therapeutics Inc (PSTV) and Tenaya Therapeutics, Inc. (TNYA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PSTV	TNYA	Difference
Sharpe ratio Return per unit of total volatility	-0.26	0.64	-0.90
Sortino ratio Return per unit of downside risk	0.66	1.70	-1.04
Omega ratio Gain probability vs. loss probability	1.08	1.21	-0.13
Calmar ratio Return relative to maximum drawdown	-0.27	0.97	-1.25
Martin ratio Return relative to average drawdown	-0.47	1.55	-2.02
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PSTV vs. TNYA - Sharpe Ratio Comparison

The current PSTV Sharpe Ratio is -0.26, which is lower than the TNYA Sharpe Ratio of 0.64. The chart below compares the historical Sharpe Ratios of PSTV and TNYA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PSTV	TNYA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.26	0.64	-0.90
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.33	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.37	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.35	-0.42	+0.08

Drawdowns

PSTV vs. TNYA - Drawdown Comparison

The maximum PSTV drawdown since its inception was -100.00%, roughly equal to the maximum TNYA drawdown of -98.69%. Use the drawdown chart below to compare losses from any high point for PSTV and TNYA.

Drawdown Indicators

	PSTV	TNYA	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-98.69%	-1.31%
Max Drawdown (1Y) Largest decline over 1 year	-86.87%	-73.81%	-13.06%
Max Drawdown (3Y) Largest decline over 3 years	-97.03%	-94.92%	-2.11%
Max Drawdown (5Y) Largest decline over 5 years	-99.73%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	—	—
Current Drawdown Current decline from peak	-100.00%	-97.33%	-2.67%
Average Drawdown Average peak-to-trough decline	-79.49%	-82.08%	+2.59%
Ulcer Index Depth and duration of drawdowns from previous peaks	50.75%	46.25%	+4.50%

Volatility

PSTV vs. TNYA - Volatility Comparison

The current volatility for Plus Therapeutics Inc (PSTV) is 23.89%, while Tenaya Therapeutics, Inc. (TNYA) has a volatility of 29.89%. This indicates that PSTV experiences smaller price fluctuations and is considered to be less risky than TNYA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PSTV	TNYA	Difference
Volatility (1M) Calculated over the trailing 1-month period	23.89%	29.89%	-6.00%
Volatility (6M) Calculated over the trailing 6-month period	88.49%	86.15%	+2.34%
Volatility (1Y) Calculated over the trailing 1-year period	157.00%	113.37%	+43.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	198.00%	109.13%	+88.87%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	184.24%	109.13%	+75.11%

Dividends

PSTV vs. TNYA - Dividend Comparison

Neither PSTV nor TNYA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PSTV and TNYA in my portfolio?

PSTV and TNYA have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PSTV or TNYA?

TNYA has higher volatility (29.89%) compared to PSTV (23.89%). In terms of maximum drawdown, PSTV dropped -100.00% vs TNYA's -98.69%.

Which has better risk-adjusted returns?

TNYA currently has the higher Sharpe Ratio (0.64 vs -0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.