INCY vs. INSM

Last updated Apr 2, 2026

Compare and contrast key facts about Incyte Corporation (INCY) and Insmed Incorporated (INSM).

Performance

INCY vs. INSM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Incyte Corporation (INCY) and Insmed Incorporated (INSM). The values are adjusted to include any dividend payments, if applicable.

INCY vs. INSM - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
INCY Incyte Corporation	-4.53%	43.00%	10.00%	-21.83%	9.43%	-15.61%	-0.39%	37.32%	-32.86%	-5.55%
INSM Insmed Incorporated	-5.27%	152.09%	122.78%	55.11%	-26.65%	-18.17%	39.41%	82.01%	-57.92%	135.68%

Fundamentals

Market Cap INCY : $19.31B INSM : $35.22B
EPS INCY : $6.38 INSM : -$6.23
PS Ratio INCY : 3.70 INSM : 55.67
PB Ratio INCY : 3.74 INSM : 47.66
Total Revenue (TTM) INCY : $5.14B INSM : $606.42M
Gross Profit (TTM) INCY : $4.74B INSM : $483.49M
EBITDA (TTM) INCY : $1.68B INSM : -$1.19B

Returns By Period

In the year-to-date period, INCY achieves a -4.53% return, which is significantly higher than INSM's -5.27% return. Over the past 10 years, INCY has underperformed INSM with an annualized return of 2.55%, while INSM has yielded a comparatively higher 29.27% annualized return.

INCY

• 1D: 0.19%
• 1M: -5.74%
• YTD: -4.53%
• 6M: 8.77%
• 1Y: 54.82%
• 3Y*: 9.27%
• 5Y*: 2.58%
• 10Y*: 2.55%

INSM

• 1D: 0.82%
• 1M: 12.67%
• YTD: -5.27%
• 6M: 11.94%
• 1Y: 128.97%
• 3Y*: 113.04%
• 5Y*: 36.00%
• 10Y*: 29.27%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

INCY vs. INSM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

INCY

INCY Risk / Return Rank: 84
INCY Sharpe Ratio Rank: 85
INCY Sortino Ratio Rank: 83
INCY Omega Ratio Rank: 80
INCY Calmar Ratio Rank: 85
INCY Martin Ratio Rank: 86

INSM

INSM Risk / Return Rank: 90
INSM Sharpe Ratio Rank: 93
INSM Sortino Ratio Rank: 93
INSM Omega Ratio Rank: 93
INSM Calmar Ratio Rank: 86
INSM Martin Ratio Rank: 85

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

INCY vs. INSM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Incyte Corporation (INCY) and Insmed Incorporated (INSM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	INCY	INSM	Difference
Sharpe ratio Return per unit of total volatility	1.62	2.46	-0.83
Sortino ratio Return per unit of downside risk	2.30	3.31	-1.01
Omega ratio Gain probability vs. loss probability	1.29	1.46	-0.17
Calmar ratio Return relative to maximum drawdown	3.04	3.25	-0.21
Martin ratio Return relative to average drawdown	8.49	7.96	+0.53
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

INCY vs. INSM - Sharpe Ratio Comparison

The current INCY Sharpe Ratio is 1.62, which is lower than the INSM Sharpe Ratio of 2.46. The chart below compares the historical Sharpe Ratios of INCY and INSM, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	INCY	INSM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.62	2.46	-0.83
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.09	0.50	-0.41
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.07	0.38	-0.30
Sharpe Ratio (All Time) Calculated using the full available price history	0.21	0.00	+0.21

Correlation

The correlation between INCY and INSM is 0.25, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

INCY vs. INSM - Dividend Comparison

Neither INCY nor INSM has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

INCY vs. INSM - Drawdown Comparison

The maximum INCY drawdown since its inception was -98.54%, roughly equal to the maximum INSM drawdown of -98.65%. Use the drawdown chart below to compare losses from any high point for INCY and INSM.

Drawdown Indicators

	INCY	INSM	Difference
Max Drawdown Largest peak-to-trough decline	-98.54%	-98.65%	+0.11%
Max Drawdown (1Y) Largest decline over 1 year	-18.33%	-35.67%	+17.34%
Max Drawdown (5Y) Largest decline over 5 years	-41.53%	-54.85%	+13.32%
Max Drawdown (10Y) Largest decline over 10 years	-66.47%	-64.84%	-1.63%
Current Drawdown Current decline from peak	-38.23%	-22.02%	-16.21%
Average Drawdown Average peak-to-trough decline	-60.04%	-86.43%	+26.39%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.57%	14.59%	-8.02%

Volatility

INCY vs. INSM - Volatility Comparison

The current volatility for Incyte Corporation (INCY) is 7.59%, while Insmed Incorporated (INSM) has a volatility of 15.96%. This indicates that INCY experiences smaller price fluctuations and is considered to be less risky than INSM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	INCY	INSM	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.59%	15.96%	-8.37%
Volatility (6M) Calculated over the trailing 6-month period	23.76%	35.48%	-11.72%
Volatility (1Y) Calculated over the trailing 1-year period	33.95%	53.17%	-19.22%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	29.15%	72.38%	-43.23%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	34.60%	78.15%	-43.55%

Financials