WDNA vs. VOO

Last updated Jun 23, 2026

WDNA (WisdomTree BioRevolution Fund) and VOO (Vanguard S&P 500 ETF) are both exchange-traded funds - WDNA is a Health & Biotech Equities fund tracking the WisdomTree BioRevolution Index, while VOO is a S&P 500 fund tracking the S&P 500 Index. Both are passively managed. Over the past 5 years, WDNA returned -4.94%/yr vs 13.58%/yr for VOO. A 0.65 correlation means they provide meaningful diversification when combined. WDNA charges 0.45%/yr vs 0.03%/yr for VOO.

Performance

WDNA vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in WisdomTree BioRevolution Fund (WDNA) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, WDNA achieves a 12.77% return, which is significantly higher than VOO's 9.75% return.

WDNA

• 1D: 0.90%
• 1M: 8.40%
• YTD: 12.77%
• 6M: 10.12%
• 1Y: 49.11%
• 3Y*: 5.29%
• 5Y*: -4.94%
• 10Y*: —

VOO

• 1D: -0.29%
• 1M: 0.08%
• YTD: 9.75%
• 6M: 9.30%
• 1Y: 26.77%
• 3Y*: 21.36%
• 5Y*: 13.58%
• 10Y*: 15.77%

*Multi-year figures are annualized to reflect compound growth (CAGR)

WDNA vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
WDNA WisdomTree BioRevolution Fund	12.77%	22.68%	-14.18%	-2.07%	-26.29%	-4.92%
VOO Vanguard S&P 500 ETF	9.75%	17.82%	24.98%	26.32%	-18.17%	14.13%

Correlation

The correlation between WDNA and VOO is 0.53, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.53
Correlation (3Y) Calculated over the trailing 3-year period	0.59
Correlation (5Y) Calculated over the trailing 5-year period	0.65
Correlation (All Time) Calculated using the full available price history since Jun 3, 2021	0.65

The correlation between WDNA and VOO shifts across timeframes, from 0.53 (1 year) to 0.65 (5 years), reflecting how their relationship changes across market environments.

WDNA vs. VOO - Sectors Allocation Comparison

Sectors	WDNA	VOO
Healthcare	85.0%	8.3%
Basic Materials	6.5%	1.7%
Consumer Defensive	3.0%	4.5%
Energy	1.1%	3.2%
Communication Services	-	10.5%
Consumer Cyclical	-	9.8%
Financial Services	-	10.9%
Industrials	-	7.6%
Real Estate	-	1.8%
Technology	-	39.1%
Utilities	-	2.5%

Return for Risk

WDNA vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

WDNA

WDNA Risk / Return Rank: 61
WDNA Sharpe Ratio Rank: 58
WDNA Sortino Ratio Rank: 60
WDNA Omega Ratio Rank: 51
WDNA Calmar Ratio Rank: 82
WDNA Martin Ratio Rank: 56

VOO

VOO Risk / Return Rank: 68
VOO Sharpe Ratio Rank: 70
VOO Sortino Ratio Rank: 67
VOO Omega Ratio Rank: 69
VOO Calmar Ratio Rank: 63
VOO Martin Ratio Rank: 74

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

WDNA vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WisdomTree BioRevolution Fund (WDNA) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	WDNA	VOO	Difference
Sharpe ratio: Return per unit of total volatility	1.91	2.17	-0.27
Sortino ratio: Return per unit of downside risk	2.73	2.93	-0.20
Omega ratio: Gain probability vs. loss probability	1.31	1.39	-0.08
Calmar ratio: Return relative to maximum drawdown	4.22	3.02	+1.20
Martin ratio: Return relative to average drawdown	9.45	13.58	-4.13

WDNA vs. VOO - Sharpe Ratio Comparison

The current WDNA Sharpe Ratio is 1.91, which is comparable to the VOO Sharpe Ratio of 2.17. The chart below compares the historical Sharpe Ratios of WDNA and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

WDNA vs. VOO - Drawdown Comparison

The maximum WDNA drawdown since its inception was -58.87%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for WDNA and VOO.

Drawdown Indicators

	WDNA	VOO	Difference
Max Drawdown Largest peak-to-trough decline	-58.87%	-33.99%	-24.88%
Max Drawdown (1Y) Largest decline over 1 year	-11.70%	-8.90%	-2.80%
Max Drawdown (3Y) Largest decline over 3 years	-38.25%	-18.69%	-19.56%
Max Drawdown (5Y) Largest decline over 5 years	-58.87%	-24.52%	-34.35%
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	-27.41%	-1.74%	-25.67%
Average Drawdown Average peak-to-trough decline	-35.57%	-3.68%	-31.89%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.21%	1.98%	+3.23%

Volatility

WDNA vs. VOO - Volatility Comparison

WisdomTree BioRevolution Fund (WDNA) has a higher volatility of 7.42% compared to Vanguard S&P 500 ETF (VOO) at 4.60%. This indicates that WDNA's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	WDNA	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.42%	4.60%	+2.82%
Volatility (6M) Calculated over the trailing 6-month period	16.98%	9.73%	+7.25%
Volatility (1Y) Calculated over the trailing 1-year period	25.95%	12.39%	+13.56%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.14%	16.90%	+8.24%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.07%	18.05%	+7.02%

WDNA vs. VOO - Expense Ratio Comparison

WDNA has a 0.45% expense ratio, which is higher than VOO's 0.03% expense ratio.

Dividends

WDNA vs. VOO - Dividend Comparison

WDNA's dividend yield for the trailing twelve months is around 4.05%, more than VOO's 1.04% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
VOO Vanguard S&P 500 ETF	1.04%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%
WDNA WisdomTree BioRevolution Fund	4.05%	4.57%	0.75%	0.80%	0.38%	0.10%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both WDNA and VOO in my portfolio?

WDNA and VOO have a correlation of 0.53, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, WDNA or VOO?

WDNA has higher volatility (7.42%) compared to VOO (4.60%). In terms of maximum drawdown, WDNA dropped -58.87% vs VOO's -33.99%.

Which ETF is better, WDNA or VOO?

On 5-year performance, VOO leads with 13.58% vs -4.94% for WDNA. On fees, VOO is cheaper at 0.03% per year. On volatility, VOO has been the lower-risk option at 4.60%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, WDNA or VOO?

Over the 5-year period, VOO has performed better with a 13.58% return vs -4.94%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, WDNA or VOO?

VOO is cheaper with a 0.03% expense ratio, compared with 0.45% for WDNA.

Which ETF pays a higher dividend yield, WDNA or VOO?

WDNA has the higher dividend yield at 4.05%, compared with 1.04% for VOO.

What is the main difference between WDNA and VOO?

WDNA is categorized as Health & Biotech Equities, while VOO is S&P 500. WDNA tracks WisdomTree BioRevolution Index, while VOO tracks S&P 500 Index. They also come from different issuers: WisdomTree and Vanguard. Their fees differ too: 0.45% for WDNA and 0.03% for VOO.

Which has better risk-adjusted returns?

VOO currently has the higher Sharpe Ratio (2.17 vs 1.91), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.