IBRN vs. GERM

Last updated Jun 3, 2026

IBRN (iShares Neuroscience and Healthcare ETF) and GERM (Amplify Treatments, Testing and Advancements ETF) are both Health & Biotech Equities funds - IBRN tracks the NYSE FactSet Global Neuro Biopharma and MedTech Index while GERM tracks the Prime Treatments, Testing and Advancements Index. Both are passively managed. Over the past year, IBRN returned 52.57% vs 0.00% for GERM. IBRN charges 0.47%/yr vs 0.68%/yr for GERM.

Performance

IBRN vs. GERM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Neuroscience and Healthcare ETF (IBRN) and Amplify Treatments, Testing and Advancements ETF (GERM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

IBRN

• 1D: -4.52%
• 1M: -1.90%
• YTD: 4.62%
• 6M: 12.73%
• 1Y: 52.57%
• 3Y*: 11.10%
• 5Y*: —
• 10Y*: —

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBRN vs. GERM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
IBRN iShares Neuroscience and Healthcare ETF	4.62%	28.49%	5.28%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

IBRN vs. GERM - Sectors Allocation Comparison

Sectors	IBRN	GERM
Healthcare	100.0%	99.3%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	0.4%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IBRN vs. GERM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBRN

IBRN Risk / Return Rank: 69
IBRN Sharpe Ratio Rank: 61
IBRN Sortino Ratio Rank: 62
IBRN Omega Ratio Rank: 53
IBRN Calmar Ratio Rank: 92
IBRN Martin Ratio Rank: 79

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBRN vs. GERM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and Amplify Treatments, Testing and Advancements ETF (GERM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IBRN	GERM	Difference
Sharpe ratio Return per unit of total volatility	2.09	—	—
Sortino ratio Return per unit of downside risk	2.94	—	—
Omega ratio Gain probability vs. loss probability	1.34	—	—
Calmar ratio Return relative to maximum drawdown	6.30	—	—
Martin ratio Return relative to average drawdown	15.59	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	IBRN	GERM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.09	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.37	—	—

Drawdowns

IBRN vs. GERM - Drawdown Comparison

The maximum IBRN drawdown since its inception was -35.38%, which is greater than GERM's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for IBRN and GERM.

Drawdown Indicators

	IBRN	GERM	Difference
Max Drawdown Largest peak-to-trough decline	-35.38%	0.00%	-35.38%
Max Drawdown (1Y) Largest decline over 1 year	-8.80%	0.00%	-8.80%
Max Drawdown (3Y) Largest decline over 3 years	-35.38%	—	—
Current Drawdown Current decline from peak	-6.28%	0.00%	-6.28%
Average Drawdown Average peak-to-trough decline	-9.83%	0.00%	-9.83%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.56%	0.00%	+3.56%

Volatility

IBRN vs. GERM - Volatility Comparison

iShares Neuroscience and Healthcare ETF (IBRN) has a higher volatility of 7.66% compared to Amplify Treatments, Testing and Advancements ETF (GERM) at 0.00%. This indicates that IBRN's price experiences larger fluctuations and is considered to be riskier than GERM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBRN	GERM	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.66%	0.00%	+7.66%
Volatility (6M) Calculated over the trailing 6-month period	19.29%	0.00%	+19.29%
Volatility (1Y) Calculated over the trailing 1-year period	25.38%	0.00%	+25.38%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.32%	0.00%	+25.32%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.32%	0.00%	+25.32%

IBRN vs. GERM - Expense Ratio Comparison

IBRN has a 0.47% expense ratio, which is lower than GERM's 0.68% expense ratio.

Dividends

IBRN vs. GERM - Dividend Comparison

IBRN's dividend yield for the trailing twelve months is around 0.95%, while GERM has not paid dividends to shareholders.

Position	TTM	2025	2024	2023
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%	0.00%
IBRN iShares Neuroscience and Healthcare ETF	0.95%	0.99%	0.40%	0.06%

Frequently Asked Questions

Which is riskier, IBRN or GERM?

IBRN has higher volatility (7.66%) compared to GERM (0.00%). In terms of maximum drawdown, IBRN dropped -35.38% vs GERM's 0.00%.

Which ETF is better, IBRN or GERM?

On 1-year performance, IBRN leads with 52.57% vs 0.00% for GERM. On fees, IBRN is cheaper at 0.47% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBRN or GERM?

Over the 1-year period, IBRN has performed better with a 52.57% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBRN or GERM?

IBRN is cheaper with a 0.47% expense ratio, compared with 0.68% for GERM.

Which ETF pays a higher dividend yield, IBRN or GERM?

IBRN has the higher dividend yield at 0.95%, compared with 0.00% for GERM.

What is the main difference between IBRN and GERM?

IBRN tracks NYSE FactSet Global Neuro Biopharma and MedTech Index, while GERM tracks Prime Treatments, Testing and Advancements Index. They also come from different issuers: iShares and Amplify. Their fees differ too: 0.47% for IBRN and 0.68% for GERM.