FCLO vs. SBIO

Last updated Jun 25, 2026

FCLO (Fidelity CLO ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both exchange-traded funds - FCLO is a CLO fund actively managed by Fidelity, while SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index. FCLO is actively managed, while SBIO is passively managed. At a correlation of -0.13, they often move in opposite directions. FCLO charges 0.45%/yr vs 0.50%/yr for SBIO.

Performance

FCLO vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Fidelity CLO ETF (FCLO) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

FCLO

• 1D: 0.02%
• 1M: 0.36%
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

SBIO

• 1D: 2.88%
• 1M: 14.15%
• YTD: 18.79%
• 6M: 15.02%
• 1Y: 98.14%
• 3Y*: 25.22%
• 5Y*: 4.73%
• 10Y*: 11.54%

*Multi-year figures are annualized to reflect compound growth (CAGR)

FCLO vs. SBIO - Yearly Performance Comparison

	2026 (YTD)
FCLO Fidelity CLO ETF	1.87%
SBIO ALPS Medical Breakthroughs ETF	20.22%

Correlation

The correlation between FCLO and SBIO is -0.13, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (All Time) Calculated using the full available price history since Feb 12, 2026	-0.13

Return for Risk

FCLO vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FCLO

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

SBIO

SBIO Risk / Return Rank: 93
SBIO Sharpe Ratio Rank: 95
SBIO Sortino Ratio Rank: 93
SBIO Omega Ratio Rank: 88
SBIO Calmar Ratio Rank: 96
SBIO Martin Ratio Rank: 93

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FCLO vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Fidelity CLO ETF (FCLO) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	FCLO	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	—	3.24	—
Sortino ratio: Return per unit of downside risk	—	4.11	—
Omega ratio: Gain probability vs. loss probability	—	1.49	—
Calmar ratio: Return relative to maximum drawdown	—	7.80	—
Martin ratio: Return relative to average drawdown	—	21.75	—

Drawdowns

FCLO vs. SBIO - Drawdown Comparison

The maximum FCLO drawdown since its inception was -0.58%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for FCLO and SBIO.

Drawdown Indicators

	FCLO	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-0.58%	-63.06%	+62.48%
Max Drawdown (1Y) Largest decline over 1 year	—	-12.66%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-42.44%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-0.06%	-0.77%	+0.71%
Average Drawdown Average peak-to-trough decline	-0.08%	-28.36%	+28.28%
Ulcer Index Depth and duration of drawdowns from previous peaks	—	4.53%	—

Volatility

Volatility by Period

	FCLO	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	11.21%	—
Volatility (6M) Calculated over the trailing 6-month period	—	23.75%	—
Volatility (1Y) Calculated over the trailing 1-year period	1.35%	30.51%	-29.16%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	1.35%	33.76%	-32.41%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	1.35%	33.20%	-31.85%

FCLO vs. SBIO - Expense Ratio Comparison

FCLO has a 0.45% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

FCLO vs. SBIO - Dividend Comparison

FCLO's dividend yield for the trailing twelve months is around 1.56%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
FCLO Fidelity CLO ETF	1.56%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Can I hold both FCLO and SBIO in my portfolio?

FCLO and SBIO have a correlation of -0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, FCLO or SBIO?

On fees, FCLO is cheaper at 0.45% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, FCLO or SBIO?

FCLO is cheaper with a 0.45% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, FCLO or SBIO?

FCLO has the higher dividend yield at 1.56%, compared with 0.00% for SBIO.

What is the main difference between FCLO and SBIO?

FCLO is categorized as CLO, while SBIO is Health & Biotech Equities. They also come from different issuers: Fidelity and SS&C. Their fees differ too: 0.45% for FCLO and 0.50% for SBIO.