EQ vs. QSI

Last updated Jun 4, 2026

EQ (Equillium Inc) and QSI (Quantum-Si incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, EQ returned 70.29%/yr vs -11.03%/yr for QSI. At a 0.14 correlation, their price movements are largely independent.

Performance

EQ vs. QSI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Equillium Inc (EQ) and Quantum-Si incorporated (QSI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EQ achieves a 100.65% return, which is significantly higher than QSI's 8.18% return.

EQ

• 1D: 11.47%
• 1M: 48.10%
• YTD: 100.65%
• 6M: 256.86%
• 1Y: 771.15%
• 3Y*: 70.29%
• 5Y*: -14.81%
• 10Y*: —

QSI

• 1D: -4.03%
• 1M: 22.49%
• YTD: 8.18%
• 6M: -12.50%
• 1Y: -32.39%
• 3Y*: -11.03%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

EQ vs. QSI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
EQ Equillium Inc	100.65%	107.16%	3.49%	-31.79%	-71.88%	-45.99%
QSI Quantum-Si incorporated	8.18%	-59.26%	34.33%	9.84%	-76.75%	-26.31%

Correlation

The correlation between EQ and QSI is 0.18, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.18
Correlation (3Y) Calculated over the trailing 3-year period	0.14
Correlation (All Time) Calculated using the full available price history since Jun 11, 2021	0.14

Fundamentals

Market Cap EQ : $299.43M QSI : $257.60M
EPS EQ : -$0.29 QSI : -$0.51
PB Ratio EQ : 5.03 QSI : 1.28
Total Revenue (TTM) EQ : $0.00 QSI : $1.85M
Gross Profit (TTM) EQ : -$83.00K QSI : -$3.71M
EBITDA (TTM) EQ : -$19.95M QSI : -$104.05M

Return for Risk

EQ vs. QSI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

EQ

EQ Risk / Return Rank: 97
EQ Sharpe Ratio Rank: 98
EQ Sortino Ratio Rank: 97
EQ Omega Ratio Rank: 94
EQ Calmar Ratio Rank: 98
EQ Martin Ratio Rank: 98

QSI

QSI Risk / Return Rank: 28
QSI Sharpe Ratio Rank: 26
QSI Sortino Ratio Rank: 31
QSI Omega Ratio Rank: 30
QSI Calmar Ratio Rank: 25
QSI Martin Ratio Rank: 28

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EQ vs. QSI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Equillium Inc (EQ) and Quantum-Si incorporated (QSI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	EQ	QSI	Difference
Sharpe ratio: Return per unit of total volatility	4.69	-0.35	+5.04
Sortino ratio: Return per unit of downside risk	4.68	0.03	+4.65
Omega ratio: Gain probability vs. loss probability	1.55	1.00	+0.55
Calmar ratio: Return relative to maximum drawdown	13.47	-0.45	+13.92
Martin ratio: Return relative to average drawdown	29.64	-0.67	+30.31
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

EQ vs. QSI - Sharpe Ratio Comparison

The current EQ Sharpe Ratio is 4.69, which is higher than the QSI Sharpe Ratio of -0.35. The chart below compares the historical Sharpe Ratios of EQ and QSI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	EQ	QSI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.69	-0.35	+5.04
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.13	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.06	-0.29	+0.22

Drawdowns

EQ vs. QSI - Drawdown Comparison

The maximum EQ drawdown since its inception was -98.91%, roughly equal to the maximum QSI drawdown of -95.33%. Use the drawdown chart below to compare losses from any high point for EQ and QSI.

Drawdown Indicators

	EQ	QSI	Difference
Max Drawdown Largest peak-to-trough decline	-98.91%	-95.33%	-3.58%
Max Drawdown (1Y) Largest decline over 1 year	-57.79%	-72.95%	+15.16%
Max Drawdown (3Y) Largest decline over 3 years	-90.33%	-83.73%	-6.60%
Max Drawdown (5Y) Largest decline over 5 years	-96.20%	—	—
Current Drawdown Current decline from peak	-88.26%	-91.22%	+2.96%
Average Drawdown Average peak-to-trough decline	-84.98%	-79.26%	-5.72%
Ulcer Index Depth and duration of drawdowns from previous peaks	26.22%	48.36%	-22.14%

Volatility

EQ vs. QSI - Volatility Comparison

Equillium Inc (EQ) has a higher volatility of 39.76% compared to Quantum-Si incorporated (QSI) at 22.20%. This indicates that EQ's price experiences larger fluctuations and is considered to be riskier than QSI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	EQ	QSI	Difference
Volatility (1M) Calculated over the trailing 1-month period	39.76%	22.20%	+17.56%
Volatility (6M) Calculated over the trailing 6-month period	79.48%	58.29%	+21.19%
Volatility (1Y) Calculated over the trailing 1-year period	166.03%	92.68%	+73.35%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	114.85%	125.41%	-10.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	288.90%	125.41%	+163.49%

Dividends

EQ vs. QSI - Dividend Comparison

Neither EQ nor QSI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both EQ and QSI in my portfolio?

EQ and QSI have a correlation of 0.18, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, EQ or QSI?

EQ has higher volatility (39.76%) compared to QSI (22.20%). In terms of maximum drawdown, EQ dropped -98.91% vs QSI's -95.33%.

Which has better risk-adjusted returns?

EQ currently has the higher Sharpe Ratio (4.69 vs -0.35), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.