ENTA vs. OMER

Last updated Aug 1, 2026

ENTA (Enanta Pharmaceuticals, Inc.) and OMER (Omeros Corporation) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, ENTA returned -5.43%/yr vs -0.03%/yr for OMER. Their 0.27 correlation means their historical movements had little consistent relationship.

Performance

ENTA vs. OMER - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Enanta Pharmaceuticals, Inc. (ENTA) and Omeros Corporation (OMER). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ENTA achieves a -20.10% return, which is significantly higher than OMER's -31.06% return. Over the past 10 years, ENTA has underperformed OMER with an annualized return of -5.43%, while OMER has yielded a comparatively higher -0.03% annualized return.

ENTA

• 1D: -3.08%
• 1M: -16.61%
• 6M: -2.33%
• YTD: -20.10%
• 1Y: 77.22%
• 3Y*: -12.24%
• 5Y*: -21.49%
• 10Y*: -5.43%
• ALL TIME*: -1.05%

OMER

• 1D: -0.75%
• 1M: 27.59%
• 6M: 1.28%
• YTD: -31.06%
• 1Y: 227.98%
• 3Y*: 41.60%
• 5Y*: -3.97%
• 10Y*: -0.03%
• ALL TIME*: 1.78%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ENTA Enanta Pharmaceuticals, Inc.	$1.83M	$2.27M	$2.92M
OMER Omeros Corporation	$16.98M	$15.21M	$19.60M

ENTA vs. OMER - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ENTA Enanta Pharmaceuticals, Inc.	-20.10%	174.26%	-38.89%	-79.77%	-37.79%	77.62%	-31.85%	-12.78%	20.71%	75.16%
OMER Omeros Corporation	-31.06%	73.84%	202.14%	44.69%	-64.85%	-54.99%	1.38%	26.48%	-42.67%	95.87%

Correlation

The correlation between ENTA and OMER is 0.31, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.31
Correlation (3Y) Balances recent behavior with more history.	0.29
Correlation (5Y) Shows whether the relationship held over a longer period.	0.29
Correlation (10Y) Provides a long-term view across more market conditions.	0.28
Correlation (All Time) Calculated using the full available price history since Mar 21, 2013	0.27

Fundamentals

Market Cap ENTA : $366.39M OMER : $856.92M
EPS ENTA : -$2.60 OMER : -$0.05
Total Revenue (TTM) ENTA : $69.21M OMER : $0.00
Gross Profit (TTM) ENTA : $33.44M OMER : -$10.29M
EBITDA (TTM) ENTA : -$61.85M OMER : -$110.44M

Return for Risk

ENTA vs. OMER — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ENTA

ENTA Risk / Return Rank: 76
ENTA Sharpe Ratio Rank: 66
ENTA Sortino Ratio Rank: 82
ENTA Omega Ratio Rank: 82
ENTA Calmar Ratio Rank: 78
ENTA Martin Ratio Rank: 73

OMER

OMER Risk / Return Rank: 90
OMER Sharpe Ratio Rank: 78
OMER Sortino Ratio Rank: 97
OMER Omega Ratio Rank: 96
OMER Calmar Ratio Rank: 93
OMER Martin Ratio Rank: 86

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ENTA vs. OMER - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Enanta Pharmaceuticals, Inc. (ENTA) and Omeros Corporation (OMER). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ENTA	OMER	Difference
Sharpe ratio: Return per unit of total volatility	0.61	1.10	-0.49
Sortino ratio: Return per unit of downside risk	2.19	4.20	-2.01
Omega ratio: Gain probability vs. loss probability	1.28	1.52	-0.24
Calmar ratio: Return relative to maximum drawdown	1.94	4.19	-2.25
Martin ratio: Return relative to average drawdown	3.44	7.55	-4.11

ENTA vs. OMER - Sharpe Ratio Comparison

The current ENTA Sharpe Ratio is 0.61, which is lower than the OMER Sharpe Ratio of 1.10. The chart below compares the historical Sharpe Ratios of ENTA and OMER, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ENTA vs. OMER - Drawdown Comparison

The maximum ENTA drawdown since its inception was -96.63%, roughly equal to the maximum OMER drawdown of -95.95%. Use the drawdown chart below to compare losses from any high point for ENTA and OMER.

Drawdown Indicators

	ENTA	OMER	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-95.95%	-0.68%
Max Drawdown (1Y) Largest decline over 1 year	-34.30%	-49.52%	+15.22%
Max Drawdown (3Y) Largest decline over 3 years	-78.51%	-75.56%	-2.95%
Max Drawdown (5Y) Largest decline over 5 years	-95.62%	-93.37%	-2.25%
Max Drawdown (10Y) Largest decline over 10 years	-96.63%	-95.95%	-0.68%
Current Drawdown Current decline from peak	-90.03%	-55.64%	-34.39%
Average Drawdown Average peak-to-trough decline	-49.66%	-48.60%	-1.06%
Ulcer Index Depth and duration of drawdowns from previous peaks	19.35%	27.43%	-8.08%

Volatility

ENTA vs. OMER - Volatility Comparison

The current volatility for Enanta Pharmaceuticals, Inc. (ENTA) is 11.70%, while Omeros Corporation (OMER) has a volatility of 24.61%. This indicates that ENTA experiences smaller price fluctuations and is considered to be less risky than OMER based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ENTA	OMER	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.70%	24.61%	-12.91%
Volatility (6M) Calculated over the trailing 6-month period	34.43%	52.47%	-18.04%
Volatility (1Y) Calculated over the trailing 1-year period	108.78%	188.53%	-79.75%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	73.65%	135.68%	-62.03%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.73%	111.33%	-50.60%

Dividends

ENTA vs. OMER - Dividend Comparison

Neither ENTA nor OMER has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ENTA and OMER in my portfolio?

ENTA and OMER have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ENTA or OMER?

OMER has higher volatility (24.61%) compared to ENTA (11.70%). In terms of maximum drawdown, ENTA dropped -96.63% vs OMER's -95.95%.

Which has better risk-adjusted returns?

OMER currently has the higher Sharpe Ratio (1.10 vs 0.61), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.