ENTA vs. XBI

Last updated Jun 4, 2026

ENTA (Enanta Pharmaceuticals, Inc.) is a stock, while XBI (SPDR S&P Biotech ETF) is Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index. Over the past 10 years, ENTA returned -7.84%/yr vs 8.53%/yr for XBI. A 0.52 correlation means they provide meaningful diversification when combined.

Performance

ENTA vs. XBI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Enanta Pharmaceuticals, Inc. (ENTA) and SPDR S&P Biotech ETF (XBI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ENTA achieves a -28.73% return, which is significantly lower than XBI's 6.48% return. Over the past 10 years, ENTA has underperformed XBI with an annualized return of -7.84%, while XBI has yielded a comparatively higher 8.53% annualized return.

ENTA

• 1D: -6.57%
• 1M: -22.70%
• YTD: -28.73%
• 6M: -21.07%
• 1Y: 56.33%
• 3Y*: -24.32%
• 5Y*: -25.08%
• 10Y*: -7.84%

XBI

• 1D: 1.62%
• 1M: -2.75%
• YTD: 6.48%
• 6M: 6.92%
• 1Y: 58.25%
• 3Y*: 14.73%
• 5Y*: 0.59%
• 10Y*: 8.53%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ENTA vs. XBI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ENTA Enanta Pharmaceuticals, Inc.	-28.73%	174.26%	-38.89%	-79.77%	-37.79%	77.62%	-31.85%	-12.78%	20.71%	75.16%
XBI SPDR S&P Biotech ETF	6.48%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%

Correlation

The correlation between ENTA and XBI is 0.45, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.45
Correlation (3Y) Calculated over the trailing 3-year period	0.48
Correlation (5Y) Calculated over the trailing 5-year period	0.53
Correlation (10Y) Calculated over the trailing 10-year period	0.54
Correlation (All Time) Calculated using the full available price history since Mar 22, 2013	0.52

The correlation between ENTA and XBI has been stable across timeframes, ranging from 0.45 to 0.54 - a consistent structural relationship.

Return for Risk

ENTA vs. XBI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ENTA

ENTA Risk / Return Rank: 69
ENTA Sharpe Ratio Rank: 58
ENTA Sortino Ratio Rank: 75
ENTA Omega Ratio Rank: 74
ENTA Calmar Ratio Rank: 71
ENTA Martin Ratio Rank: 68

XBI

XBI Risk / Return Rank: 74
XBI Sharpe Ratio Rank: 68
XBI Sortino Ratio Rank: 67
XBI Omega Ratio Rank: 60
XBI Calmar Ratio Rank: 91
XBI Martin Ratio Rank: 85

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ENTA vs. XBI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Enanta Pharmaceuticals, Inc. (ENTA) and SPDR S&P Biotech ETF (XBI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ENTA	XBI	Difference
Sharpe ratio Return per unit of total volatility	0.52	2.30	-1.78
Sortino ratio Return per unit of downside risk	2.00	3.16	-1.16
Omega ratio Gain probability vs. loss probability	1.26	1.38	-0.12
Calmar ratio Return relative to maximum drawdown	1.70	6.02	-4.32
Martin ratio Return relative to average drawdown	3.25	18.30	-15.05
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ENTA vs. XBI - Sharpe Ratio Comparison

The current ENTA Sharpe Ratio is 0.52, which is lower than the XBI Sharpe Ratio of 2.30. The chart below compares the historical Sharpe Ratios of ENTA and XBI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ENTA	XBI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.52	2.30	-1.78
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.34	0.02	-0.36
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.13	0.27	-0.40
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	0.36	-0.41

Drawdowns

ENTA vs. XBI - Drawdown Comparison

The maximum ENTA drawdown since its inception was -96.63%, which is greater than XBI's maximum drawdown of -63.89%. Use the drawdown chart below to compare losses from any high point for ENTA and XBI.

Drawdown Indicators

	ENTA	XBI	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-63.89%	-32.74%
Max Drawdown (1Y) Largest decline over 1 year	-33.29%	-9.72%	-23.57%
Max Drawdown (3Y) Largest decline over 3 years	-83.80%	-32.99%	-50.81%
Max Drawdown (5Y) Largest decline over 5 years	-95.62%	-54.71%	-40.91%
Max Drawdown (10Y) Largest decline over 10 years	-96.63%	-63.89%	-32.74%
Current Drawdown Current decline from peak	-91.11%	-24.96%	-66.15%
Average Drawdown Average peak-to-trough decline	-49.20%	-20.93%	-28.27%
Ulcer Index Depth and duration of drawdowns from previous peaks	17.40%	3.19%	+14.21%

Volatility

ENTA vs. XBI - Volatility Comparison

Enanta Pharmaceuticals, Inc. (ENTA) has a higher volatility of 13.53% compared to SPDR S&P Biotech ETF (XBI) at 9.26%. This indicates that ENTA's price experiences larger fluctuations and is considered to be riskier than XBI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ENTA	XBI	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.53%	9.26%	+4.27%
Volatility (6M) Calculated over the trailing 6-month period	35.10%	20.18%	+14.92%
Volatility (1Y) Calculated over the trailing 1-year period	110.48%	25.50%	+84.98%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	73.32%	32.18%	+41.14%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.67%	32.00%	+28.67%

Dividends

ENTA vs. XBI - Dividend Comparison

ENTA has not paid dividends to shareholders, while XBI's dividend yield for the trailing twelve months is around 0.34%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ENTA Enanta Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.34%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both ENTA and XBI in my portfolio?

ENTA and XBI have a correlation of 0.45, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ENTA or XBI?

ENTA has higher volatility (13.53%) compared to XBI (9.26%). In terms of maximum drawdown, ENTA dropped -96.63% vs XBI's -63.89%.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (2.30 vs 0.52), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.