ENTA vs. ARCT

Last updated Jun 9, 2026

ENTA (Enanta Pharmaceuticals, Inc.) and ARCT (Arcturus Therapeutics Holdings Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, ENTA returned -25.36%/yr vs -26.90%/yr for ARCT. At a 0.31 correlation, their price movements are largely independent.

Performance

ENTA vs. ARCT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Enanta Pharmaceuticals, Inc. (ENTA) and Arcturus Therapeutics Holdings Inc. (ARCT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ENTA achieves a -29.80% return, which is significantly lower than ARCT's 16.15% return.

ENTA

• 1D: -1.86%
• 1M: -27.84%
• YTD: -29.80%
• 6M: -21.93%
• 1Y: 48.19%
• 3Y*: -24.76%
• 5Y*: -25.36%
• 10Y*: -7.18%

ARCT

• 1D: -2.47%
• 1M: -22.78%
• YTD: 16.15%
• 6M: -4.43%
• 1Y: -44.33%
• 3Y*: -36.26%
• 5Y*: -26.90%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ENTA vs. ARCT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
ENTA Enanta Pharmaceuticals, Inc.	-29.80%	174.26%	-38.89%	-79.77%	-37.79%	77.62%	-21.88%
ARCT Arcturus Therapeutics Holdings Inc.	16.15%	-63.88%	-46.18%	85.91%	-54.17%	-14.68%	155.18%

Correlation

The correlation between ENTA and ARCT is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.21
Correlation (3Y) Calculated over the trailing 3-year period	0.26
Correlation (5Y) Calculated over the trailing 5-year period	0.33
Correlation (All Time) Calculated using the full available price history since Apr 17, 2020	0.31

The correlation between ENTA and ARCT shifts across timeframes, from 0.21 (1 year) to 0.33 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ENTA : $319.83M ARCT : $202.36M
EPS ENTA : -$2.67 ARCT : -$1.81
PS Ratio ENTA : 3.72 ARCT : 4.19
PB Ratio ENTA : 2.77 ARCT : 1.06
Total Revenue (TTM) ENTA : $69.21M ARCT : $46.80M
Gross Profit (TTM) ENTA : $33.44M ARCT : $40.72M
EBITDA (TTM) ENTA : -$61.85M ARCT : -$84.61M

Return for Risk

ENTA vs. ARCT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ENTA

ENTA Risk / Return Rank: 68
ENTA Sharpe Ratio Rank: 58
ENTA Sortino Ratio Rank: 74
ENTA Omega Ratio Rank: 73
ENTA Calmar Ratio Rank: 69
ENTA Martin Ratio Rank: 66

ARCT

ARCT Risk / Return Rank: 25
ARCT Sharpe Ratio Rank: 21
ARCT Sortino Ratio Rank: 28
ARCT Omega Ratio Rank: 27
ARCT Calmar Ratio Rank: 21
ARCT Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ENTA vs. ARCT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Enanta Pharmaceuticals, Inc. (ENTA) and Arcturus Therapeutics Holdings Inc. (ARCT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ENTA	ARCT	Difference
Sharpe ratio: Return per unit of total volatility	0.44	-0.48	+0.92
Sortino ratio: Return per unit of downside risk	1.88	-0.15	+2.03
Omega ratio: Gain probability vs. loss probability	1.24	0.98	+0.26
Calmar ratio: Return relative to maximum drawdown	1.41	-0.60	+2.01
Martin ratio: Return relative to average drawdown	2.72	-0.83	+3.55
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ENTA vs. ARCT - Sharpe Ratio Comparison

The current ENTA Sharpe Ratio is 0.44, which is higher than the ARCT Sharpe Ratio of -0.48. The chart below compares the historical Sharpe Ratios of ENTA and ARCT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ENTA	ARCT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.44	-0.48	+0.92
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.35	-0.29	-0.05
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.12	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	-0.13	+0.08

Drawdowns

ENTA vs. ARCT - Drawdown Comparison

The maximum ENTA drawdown since its inception was -96.63%, roughly equal to the maximum ARCT drawdown of -95.23%. Use the drawdown chart below to compare losses from any high point for ENTA and ARCT.

Drawdown Indicators

	ENTA	ARCT	Difference
Max Drawdown Largest peak-to-trough decline	-96.63%	-95.23%	-1.40%
Max Drawdown (1Y) Largest decline over 1 year	-34.30%	-74.53%	+40.23%
Max Drawdown (3Y) Largest decline over 3 years	-83.61%	-86.71%	+3.10%
Max Drawdown (5Y) Largest decline over 5 years	-95.62%	-89.87%	-5.75%
Max Drawdown (10Y) Largest decline over 10 years	-96.63%	—	—
Current Drawdown Current decline from peak	-91.24%	-94.24%	+3.00%
Average Drawdown Average peak-to-trough decline	-49.23%	-73.02%	+23.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	17.76%	53.28%	-35.52%

Volatility

ENTA vs. ARCT - Volatility Comparison

The current volatility for Enanta Pharmaceuticals, Inc. (ENTA) is 13.36%, while Arcturus Therapeutics Holdings Inc. (ARCT) has a volatility of 19.67%. This indicates that ENTA experiences smaller price fluctuations and is considered to be less risky than ARCT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ENTA	ARCT	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.36%	19.67%	-6.31%
Volatility (6M) Calculated over the trailing 6-month period	35.53%	41.10%	-5.57%
Volatility (1Y) Calculated over the trailing 1-year period	109.93%	92.73%	+17.20%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	73.36%	91.85%	-18.49%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.70%	102.23%	-41.53%

Dividends

ENTA vs. ARCT - Dividend Comparison

Neither ENTA nor ARCT has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ENTA and ARCT in my portfolio?

ENTA and ARCT have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ENTA or ARCT?

ARCT has higher volatility (19.67%) compared to ENTA (13.36%). In terms of maximum drawdown, ENTA dropped -96.63% vs ARCT's -95.23%.

Which has better risk-adjusted returns?

ENTA currently has the higher Sharpe Ratio (0.44 vs -0.48), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.