EKG vs. SBIO

Last updated Jun 5, 2026

EKG (First Trust Nasdaq Lux Digital Health Solutions ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - EKG tracks the NASDAQ Lux Health Tech Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 3 years, EKG returned 0.16%/yr vs 18.38%/yr for SBIO. A 0.60 correlation means they provide meaningful diversification when combined. EKG charges 0.65%/yr vs 0.50%/yr for SBIO.

Performance

EKG vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EKG achieves a -7.15% return, which is significantly lower than SBIO's 1.95% return.

EKG

• 1D: 3.29%
• 1M: 6.48%
• YTD: -7.15%
• 6M: -10.81%
• 1Y: 1.80%
• 3Y*: 0.16%
• 5Y*: —
• 10Y*: —

SBIO

• 1D: 2.35%
• 1M: -5.55%
• YTD: 1.95%
• 6M: 4.13%
• 1Y: 68.86%
• 3Y*: 18.38%
• 5Y*: 3.16%
• 10Y*: 8.03%

*Multi-year figures are annualized to reflect compound growth (CAGR)

EKG vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
EKG First Trust Nasdaq Lux Digital Health Solutions ETF	-7.15%	11.89%	6.53%	-0.11%	-19.59%
SBIO ALPS Medical Breakthroughs ETF	1.95%	55.07%	3.81%	8.68%	-9.58%

Correlation

The correlation between EKG and SBIO is 0.47, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.47
Correlation (3Y) Calculated over the trailing 3-year period	0.54
Correlation (All Time) Calculated using the full available price history since Mar 24, 2022	0.60

The correlation between EKG and SBIO shifts across timeframes, from 0.47 (1 year) to 0.60 (all time), reflecting how their relationship changes across market environments.

EKG vs. SBIO - Sectors Allocation Comparison

Sectors	EKG	SBIO
Healthcare	94.9%	100.0%
Technology	2.6%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-0.0%
Industrials	-	-
Real Estate	-	-
Utilities	-	-

Return for Risk

EKG vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

EKG

EKG Risk / Return Rank: 10
EKG Sharpe Ratio Rank: 10
EKG Sortino Ratio Rank: 10
EKG Omega Ratio Rank: 10
EKG Calmar Ratio Rank: 10
EKG Martin Ratio Rank: 10

SBIO

SBIO Risk / Return Rank: 76
SBIO Sharpe Ratio Rank: 74
SBIO Sortino Ratio Rank: 72
SBIO Omega Ratio Rank: 63
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EKG vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	EKG	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	0.08	2.35	-2.27
Sortino ratio: Return per unit of downside risk	0.27	3.22	-2.95
Omega ratio: Gain probability vs. loss probability	1.03	1.38	-0.34
Calmar ratio: Return relative to maximum drawdown	0.08	5.47	-5.39
Martin ratio: Return relative to average drawdown	0.18	16.23	-16.04
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

EKG vs. SBIO - Sharpe Ratio Comparison

The current EKG Sharpe Ratio is 0.08, which is lower than the SBIO Sharpe Ratio of 2.35. The chart below compares the historical Sharpe Ratios of EKG and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	EKG	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.08	2.35	-2.27
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.09	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.10	0.22	-0.32

Drawdowns

EKG vs. SBIO - Drawdown Comparison

The maximum EKG drawdown since its inception was -43.82%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for EKG and SBIO.

Drawdown Indicators

	EKG	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-43.82%	-63.06%	+19.24%
Max Drawdown (1Y) Largest decline over 1 year	-22.09%	-12.66%	-9.43%
Max Drawdown (3Y) Largest decline over 3 years	-34.49%	-42.44%	+7.95%
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-18.18%	-14.84%	-3.34%
Average Drawdown Average peak-to-trough decline	-22.66%	-28.44%	+5.78%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.77%	4.26%	+5.51%

Volatility

EKG vs. SBIO - Volatility Comparison

The current volatility for First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) is 7.72%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.85%. This indicates that EKG experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	EKG	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.72%	9.85%	-2.13%
Volatility (6M) Calculated over the trailing 6-month period	16.76%	22.76%	-6.00%
Volatility (1Y) Calculated over the trailing 1-year period	21.79%	29.40%	-7.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	27.11%	33.57%	-6.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	27.11%	33.18%	-6.07%

EKG vs. SBIO - Expense Ratio Comparison

EKG has a 0.65% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

EKG vs. SBIO - Dividend Comparison

Neither EKG nor SBIO has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
EKG First Trust Nasdaq Lux Digital Health Solutions ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Can I hold both EKG and SBIO in my portfolio?

EKG and SBIO have a correlation of 0.47, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, EKG or SBIO?

SBIO has higher volatility (9.85%) compared to EKG (7.72%). In terms of maximum drawdown, EKG dropped -43.82% vs SBIO's -63.06%.

Which ETF is better, EKG or SBIO?

On 3-year performance, SBIO leads with 18.38% vs 0.16% for EKG. On fees, SBIO is cheaper at 0.50% per year. On volatility, EKG has been the lower-risk option at 7.72%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, EKG or SBIO?

Over the 3-year period, SBIO has performed better with a 18.38% return vs 0.16%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, EKG or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.65% for EKG.

Which ETF pays a higher dividend yield, EKG or SBIO?

EKG and SBIO have nearly identical dividend yields, around 0.00%.

What is the main difference between EKG and SBIO?

EKG tracks NASDAQ Lux Health Tech Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: First Trust and SS&C. Their fees differ too: 0.65% for EKG and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.35 vs 0.08), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.