DVXV vs. SBIO

Last updated Jun 5, 2026

DVXV (WEBs Health Care XLV Defined Volatility ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - DVXV tracks the Syntax Defined Volatility XLV Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. At a 0.45 correlation, their price movements are largely independent. DVXV charges 0.89%/yr vs 0.50%/yr for SBIO.

Performance

DVXV vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in WEBs Health Care XLV Defined Volatility ETF (DVXV) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, DVXV achieves a -2.27% return, which is significantly lower than SBIO's 1.95% return.

DVXV

• 1D: 4.25%
• 1M: 6.21%
• YTD: -2.27%
• 6M: -1.59%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

SBIO

• 1D: 2.35%
• 1M: -5.55%
• YTD: 1.95%
• 6M: 4.13%
• 1Y: 68.86%
• 3Y*: 18.38%
• 5Y*: 3.16%
• 10Y*: 8.03%

*Multi-year figures are annualized to reflect compound growth (CAGR)

DVXV vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025
DVXV WEBs Health Care XLV Defined Volatility ETF	-2.27%	21.27%
SBIO ALPS Medical Breakthroughs ETF	1.95%	53.22%

Correlation

The correlation between DVXV and SBIO is 0.45, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 24, 2025	0.45

Return for Risk

DVXV vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO

SBIO Risk / Return Rank: 76
SBIO Sharpe Ratio Rank: 74
SBIO Sortino Ratio Rank: 72
SBIO Omega Ratio Rank: 63
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

DVXV vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WEBs Health Care XLV Defined Volatility ETF (DVXV) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	DVXV	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	2.35	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.09	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	1.00	0.22	+0.78

Drawdowns

DVXV vs. SBIO - Drawdown Comparison

The maximum DVXV drawdown since its inception was -14.36%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for DVXV and SBIO.

Drawdown Indicators

	DVXV	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-14.36%	-63.06%	+48.70%
Max Drawdown (1Y) Largest decline over 1 year	—	-12.66%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-42.44%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-6.92%	-14.84%	+7.92%
Average Drawdown Average peak-to-trough decline	-4.80%	-28.44%	+23.64%
Ulcer Index Depth and duration of drawdowns from previous peaks	—	4.26%	—

Volatility

Volatility by Period

	DVXV	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	9.85%	—
Volatility (6M) Calculated over the trailing 6-month period	—	22.76%	—
Volatility (1Y) Calculated over the trailing 1-year period	21.75%	29.40%	-7.65%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.75%	33.57%	-11.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	21.75%	33.18%	-11.43%

DVXV vs. SBIO - Expense Ratio Comparison

DVXV has a 0.89% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

DVXV vs. SBIO - Dividend Comparison

Neither DVXV nor SBIO has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
DVXV WEBs Health Care XLV Defined Volatility ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Can I hold both DVXV and SBIO in my portfolio?

DVXV and SBIO have a correlation of 0.45, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, DVXV or SBIO?

On fees, SBIO is cheaper at 0.50% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, DVXV or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.89% for DVXV.

Which ETF pays a higher dividend yield, DVXV or SBIO?

DVXV and SBIO have nearly identical dividend yields, around 0.00%.

What is the main difference between DVXV and SBIO?

DVXV tracks Syntax Defined Volatility XLV Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: WEBs and SS&C. Their fees differ too: 0.89% for DVXV and 0.50% for SBIO.