DNA vs. QSI

Last updated Jun 3, 2026

DNA (Ginkgo Bioworks Holdings, Inc.) and QSI (Quantum-Si incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, DNA returned -47.59%/yr vs -9.81%/yr for QSI. At a 0.50 correlation, their price movements are largely independent.

Performance

DNA vs. QSI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ginkgo Bioworks Holdings, Inc. (DNA) and Quantum-Si incorporated (QSI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both investments are quite close, with DNA having a 12.27% return and QSI slightly higher at 12.73%.

DNA

• 1D: 2.08%
• 1M: -3.81%
• YTD: 12.27%
• 6M: 8.61%
• 1Y: 30.86%
• 3Y*: -47.59%
• 5Y*: -52.72%
• 10Y*: —

QSI

• 1D: 5.08%
• 1M: 29.41%
• YTD: 12.73%
• 6M: -2.36%
• 1Y: -26.19%
• 3Y*: -9.81%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

DNA vs. QSI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
DNA Ginkgo Bioworks Holdings, Inc.	12.27%	-15.38%	-85.47%	0.00%	-79.66%	-16.90%
QSI Quantum-Si incorporated	12.73%	-59.26%	34.33%	9.84%	-76.75%	-26.31%

Correlation

The correlation between DNA and QSI is 0.54, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.54
Correlation (3Y) Calculated over the trailing 3-year period	0.51
Correlation (All Time) Calculated using the full available price history since Jun 11, 2021	0.50

The correlation between DNA and QSI has been stable across timeframes, ranging from 0.50 to 0.54 - a consistent structural relationship.

Fundamentals

Market Cap DNA : $555.73M QSI : $268.43M
EPS DNA : -$5.40 QSI : -$0.51
PS Ratio DNA : 4.32 QSI : 135.06
PB Ratio DNA : 1.25 QSI : 1.34
Total Revenue (TTM) DNA : $121.84M QSI : $1.85M
Gross Profit (TTM) DNA : $99.27M QSI : -$3.71M
EBITDA (TTM) DNA : -$218.90M QSI : -$104.05M

Return for Risk

DNA vs. QSI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

DNA

DNA Risk / Return Rank: 53
DNA Sharpe Ratio Rank: 51
DNA Sortino Ratio Rank: 56
DNA Omega Ratio Rank: 55
DNA Calmar Ratio Rank: 52
DNA Martin Ratio Rank: 50

QSI

QSI Risk / Return Rank: 31
QSI Sharpe Ratio Rank: 28
QSI Sortino Ratio Rank: 34
QSI Omega Ratio Rank: 33
QSI Calmar Ratio Rank: 28
QSI Martin Ratio Rank: 30

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

DNA vs. QSI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ginkgo Bioworks Holdings, Inc. (DNA) and Quantum-Si incorporated (QSI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	DNA	QSI	Difference
Sharpe ratio Return per unit of total volatility	0.31	-0.28	+0.60
Sortino ratio Return per unit of downside risk	1.14	0.20	+0.94
Omega ratio Gain probability vs. loss probability	1.14	1.02	+0.12
Calmar ratio Return relative to maximum drawdown	0.52	-0.36	+0.88
Martin ratio Return relative to average drawdown	0.90	-0.54	+1.44
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

DNA vs. QSI - Sharpe Ratio Comparison

The current DNA Sharpe Ratio is 0.31, which is higher than the QSI Sharpe Ratio of -0.28. The chart below compares the historical Sharpe Ratios of DNA and QSI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	DNA	QSI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.31	-0.28	+0.60
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.54	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.54	-0.28	-0.26

Drawdowns

DNA vs. QSI - Drawdown Comparison

The maximum DNA drawdown since its inception was -99.10%, roughly equal to the maximum QSI drawdown of -95.33%. Use the drawdown chart below to compare losses from any high point for DNA and QSI.

Drawdown Indicators

	DNA	QSI	Difference
Max Drawdown Largest peak-to-trough decline	-99.10%	-95.33%	-3.77%
Max Drawdown (1Y) Largest decline over 1 year	-66.05%	-72.95%	+6.90%
Max Drawdown (3Y) Largest decline over 3 years	-94.72%	-83.73%	-10.99%
Max Drawdown (5Y) Largest decline over 5 years	-99.10%	—	—
Current Drawdown Current decline from peak	-98.44%	-90.86%	-7.58%
Average Drawdown Average peak-to-trough decline	-79.64%	-79.25%	-0.39%
Ulcer Index Depth and duration of drawdowns from previous peaks	38.15%	48.24%	-10.09%

Volatility

DNA vs. QSI - Volatility Comparison

Ginkgo Bioworks Holdings, Inc. (DNA) has a higher volatility of 23.46% compared to Quantum-Si incorporated (QSI) at 21.55%. This indicates that DNA's price experiences larger fluctuations and is considered to be riskier than QSI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	DNA	QSI	Difference
Volatility (1M) Calculated over the trailing 1-month period	23.46%	21.55%	+1.91%
Volatility (6M) Calculated over the trailing 6-month period	70.34%	58.82%	+11.52%
Volatility (1Y) Calculated over the trailing 1-year period	98.67%	92.59%	+6.08%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	97.66%	125.45%	-27.79%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	96.48%	125.45%	-28.97%

Dividends

DNA vs. QSI - Dividend Comparison

Neither DNA nor QSI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both DNA and QSI in my portfolio?

DNA and QSI have a correlation of 0.54, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, DNA or QSI?

DNA has higher volatility (23.46%) compared to QSI (21.55%). In terms of maximum drawdown, DNA dropped -99.10% vs QSI's -95.33%.

Which has better risk-adjusted returns?

DNA currently has the higher Sharpe Ratio (0.31 vs -0.28), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.