DFTX vs. PBE
DFTX (Definium Therapeutics, Inc) is a stock, while PBE (Invesco Dynamic Biotechnology & Genome ETF) is Health & Biotech Equities fund tracking the Dynamic Biotech & Genome Intellidex Index (AMEX). Over the past 3 years, DFTX returned 123.15%/yr vs 12.04%/yr for PBE. At a 0.40 correlation, their price movements are largely independent.
Performance
DFTX vs. PBE - Performance Comparison
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Returns By Period
In the year-to-date period, DFTX achieves a 173.86% return, which is significantly higher than PBE's 4.26% return.
DFTX
- 1D
- 49.80%
- 1M
- 62.98%
- YTD
- 173.86%
- 6M
- 175.71%
- 1Y
- 420.14%
- 3Y*
- 123.15%
- 5Y*
- —
- 10Y*
- —
PBE
- 1D
- 1.08%
- 1M
- 4.15%
- YTD
- 4.26%
- 6M
- 2.94%
- 1Y
- 35.92%
- 3Y*
- 12.04%
- 5Y*
- 2.24%
- 10Y*
- 9.35%
DFTX vs. PBE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
DFTX Definium Therapeutics, Inc | 173.86% | 92.39% | 90.16% | 66.36% | -78.74% |
PBE Invesco Dynamic Biotechnology & Genome ETF | 4.26% | 24.84% | 1.10% | 3.71% | 2.50% |
Correlation
The correlation between DFTX and PBE is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.34 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.43 |
Correlation (All Time) Calculated using the full available price history since Jul 11, 2022 | 0.40 |
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Return for Risk
DFTX vs. PBE — Risk / Return Rank
DFTX
PBE
DFTX vs. PBE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Definium Therapeutics, Inc (DFTX) and Invesco Dynamic Biotechnology & Genome ETF (PBE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| DFTX | PBE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +3.48 | ||
| Sortino ratioReturn per unit of downside risk | +2.61 | ||
| Omega ratioGain probability vs. loss probability | 1.64 | 1.32 | +0.31 |
| Calmar ratioReturn relative to maximum drawdown | 17.09 | 3.08 | +14.01 |
| Martin ratioReturn relative to average drawdown | 53.86 | 8.64 | +45.22 |
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Drawdowns
DFTX vs. PBE - Drawdown Comparison
The maximum DFTX drawdown since its inception was -86.01%, which is greater than PBE's maximum drawdown of -45.69%. Use the drawdown chart below to compare losses from any high point for DFTX and PBE.
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Drawdown Indicators
| DFTX | PBE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -86.01% | -45.69% | -40.32% |
Max Drawdown (1Y)Largest decline over 1 year | -24.79% | -11.73% | -13.06% |
Max Drawdown (3Y)Largest decline over 3 years | -58.38% | -22.43% | -35.95% |
Max Drawdown (5Y)Largest decline over 5 years | — | -34.71% | — |
Max Drawdown (10Y)Largest decline over 10 years | — | -37.84% | — |
Current DrawdownCurrent decline from peak | 0.00% | -0.10% | +0.10% |
Average DrawdownAverage peak-to-trough decline | -50.97% | -16.20% | -34.77% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 7.86% | 4.17% | +3.69% |
Volatility
DFTX vs. PBE - Volatility Comparison
Definium Therapeutics, Inc (DFTX) has a higher volatility of 42.10% compared to Invesco Dynamic Biotechnology & Genome ETF (PBE) at 5.59%. This indicates that DFTX's price experiences larger fluctuations and is considered to be riskier than PBE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| DFTX | PBE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 42.10% | 5.59% | +36.51% |
Volatility (6M)Calculated over the trailing 6-month period | 55.59% | 13.68% | +41.91% |
Volatility (1Y)Calculated over the trailing 1-year period | 78.81% | 19.00% | +59.81% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 87.41% | 22.49% | +64.92% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 87.41% | 24.88% | +62.53% |
Dividends
DFTX vs. PBE - Dividend Comparison
DFTX has not paid dividends to shareholders, while PBE's dividend yield for the trailing twelve months is around 1.98%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
DFTX Definium Therapeutics, Inc | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
PBE Invesco Dynamic Biotechnology & Genome ETF | 1.98% | 1.00% | 0.05% | 0.02% | 0.00% | 0.00% | 0.04% | 0.00% | 0.00% | 0.57% | 0.38% | 1.12% |
Frequently Asked Questions
DFTX and PBE have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
DFTX has higher volatility (42.10%) compared to PBE (5.59%). In terms of maximum drawdown, DFTX dropped -86.01% vs PBE's -45.69%.
DFTX currently has the higher Sharpe Ratio (5.39 vs 1.90), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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