CURE vs. UUP

Last updated Jun 13, 2026

CURE (Direxion Daily Healthcare Bull 3x Shares) and UUP (Invesco DB US Dollar Index Bullish Fund) are both exchange-traded funds - CURE is a Leveraged Equities fund tracking the Health Care Select Sector Index (300%), while UUP is a Currency fund tracking the Deutsche Bank Long US Dollar Index (USDX) Futures Index. Both are passively managed. Over the past 10 years, CURE returned 13.49%/yr vs 3.13%/yr for UUP. At a correlation of -0.14, they often move in opposite directions. CURE charges 1.08%/yr vs 0.75%/yr for UUP.

Performance

CURE vs. UUP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Direxion Daily Healthcare Bull 3x Shares (CURE) and Invesco DB US Dollar Index Bullish Fund (UUP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CURE achieves a -7.96% return, which is significantly lower than UUP's 3.40% return. Over the past 10 years, CURE has outperformed UUP with an annualized return of 13.49%, while UUP has yielded a comparatively lower 3.13% annualized return.

CURE

• 1D: -0.55%
• 1M: 13.53%
• YTD: -7.96%
• 6M: -6.00%
• 1Y: 26.46%
• 3Y*: 3.05%
• 5Y*: 1.51%
• 10Y*: 13.49%

UUP

• 1D: 0.00%
• 1M: 1.60%
• YTD: 3.40%
• 6M: 3.41%
• 1Y: 6.66%
• 3Y*: 4.21%
• 5Y*: 5.89%
• 10Y*: 3.13%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CURE vs. UUP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CURE Direxion Daily Healthcare Bull 3x Shares	-7.96%	22.55%	-8.47%	-9.40%	-20.51%	88.30%	5.02%	55.66%	2.82%	69.32%
UUP Invesco DB US Dollar Index Bullish Fund	3.40%	-4.99%	13.50%	3.63%	9.46%	5.73%	-6.66%	4.09%	7.05%	-9.10%

Correlation

The correlation between CURE and UUP is -0.24, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.24
Correlation (3Y) Calculated over the trailing 3-year period	-0.18
Correlation (5Y) Calculated over the trailing 5-year period	-0.25
Correlation (10Y) Calculated over the trailing 10-year period	-0.17
Correlation (All Time) Calculated using the full available price history since Jun 15, 2011	-0.14

The correlation between CURE and UUP shifts across timeframes, from -0.25 (5 years) to -0.14 (all time), reflecting how their relationship changes across market environments.

CURE vs. UUP - Sectors Allocation Comparison

Sectors	CURE	UUP
Healthcare	100.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	97.4%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

CURE vs. UUP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CURE

CURE Risk / Return Rank: 21
CURE Sharpe Ratio Rank: 20
CURE Sortino Ratio Rank: 24
CURE Omega Ratio Rank: 22
CURE Calmar Ratio Rank: 22
CURE Martin Ratio Rank: 19

UUP

UUP Risk / Return Rank: 36
UUP Sharpe Ratio Rank: 35
UUP Sortino Ratio Rank: 34
UUP Omega Ratio Rank: 33
UUP Calmar Ratio Rank: 42
UUP Martin Ratio Rank: 36

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CURE vs. UUP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Direxion Daily Healthcare Bull 3x Shares (CURE) and Invesco DB US Dollar Index Bullish Fund (UUP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CURE	UUP	Difference
Sharpe ratio: Return per unit of total volatility	0.60	1.11	-0.51
Sortino ratio: Return per unit of downside risk	1.18	1.60	-0.41
Omega ratio: Gain probability vs. loss probability	1.13	1.20	-0.07
Calmar ratio: Return relative to maximum drawdown	0.85	1.83	-0.98
Martin ratio: Return relative to average drawdown	1.94	4.89	-2.95

CURE vs. UUP - Sharpe Ratio Comparison

The current CURE Sharpe Ratio is 0.60, which is lower than the UUP Sharpe Ratio of 1.11. The chart below compares the historical Sharpe Ratios of CURE and UUP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CURE vs. UUP - Drawdown Comparison

The maximum CURE drawdown since its inception was -69.19%, which is greater than UUP's maximum drawdown of -22.19%. Use the drawdown chart below to compare losses from any high point for CURE and UUP.

Drawdown Indicators

	CURE	UUP	Difference
Max Drawdown Largest peak-to-trough decline	-69.19%	-22.19%	-47.00%
Max Drawdown (1Y) Largest decline over 1 year	-31.10%	-3.65%	-27.45%
Max Drawdown (3Y) Largest decline over 3 years	-51.93%	-10.05%	-41.88%
Max Drawdown (5Y) Largest decline over 5 years	-52.23%	-10.37%	-41.86%
Max Drawdown (10Y) Largest decline over 10 years	-69.19%	-14.24%	-54.95%
Current Drawdown Current decline from peak	-26.94%	-3.17%	-23.77%
Average Drawdown Average peak-to-trough decline	-18.16%	-8.91%	-9.25%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.71%	1.36%	+12.35%

Volatility

CURE vs. UUP - Volatility Comparison

Direxion Daily Healthcare Bull 3x Shares (CURE) has a higher volatility of 14.30% compared to Invesco DB US Dollar Index Bullish Fund (UUP) at 1.24%. This indicates that CURE's price experiences larger fluctuations and is considered to be riskier than UUP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CURE	UUP	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.30%	1.24%	+13.06%
Volatility (6M) Calculated over the trailing 6-month period	30.87%	4.23%	+26.64%
Volatility (1Y) Calculated over the trailing 1-year period	44.32%	6.07%	+38.25%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	43.84%	7.22%	+36.62%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	49.59%	6.96%	+42.63%

CURE vs. UUP - Expense Ratio Comparison

CURE has a 1.08% expense ratio, which is higher than UUP's 0.75% expense ratio.

Dividends

CURE vs. UUP - Dividend Comparison

CURE's dividend yield for the trailing twelve months is around 1.16%, less than UUP's 3.32% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
CURE Direxion Daily Healthcare Bull 3x Shares	1.16%	1.12%	1.17%	2.02%	0.38%	0.02%	0.17%	0.40%	0.70%	0.18%
UUP Invesco DB US Dollar Index Bullish Fund	3.32%	3.43%	4.48%	6.44%	0.89%	0.00%	0.00%	2.03%	1.08%	0.10%

Frequently Asked Questions

Can I hold both CURE and UUP in my portfolio?

CURE and UUP have a correlation of -0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CURE or UUP?

CURE has higher volatility (14.30%) compared to UUP (1.24%). In terms of maximum drawdown, CURE dropped -69.19% vs UUP's -22.19%.

Which ETF is better, CURE or UUP?

On 10-year performance, CURE leads with 13.49% vs 3.13% for UUP. On fees, UUP is cheaper at 0.75% per year. On volatility, UUP has been the lower-risk option at 1.24%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, CURE or UUP?

Over the 10-year period, CURE has performed better with a 13.49% return vs 3.13%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, CURE or UUP?

UUP is cheaper with a 0.75% expense ratio, compared with 1.08% for CURE.

Which ETF pays a higher dividend yield, CURE or UUP?

UUP has the higher dividend yield at 3.32%, compared with 1.16% for CURE.

What is the main difference between CURE and UUP?

CURE is categorized as Leveraged Equities, while UUP is Currency. CURE tracks Health Care Select Sector Index (300%), while UUP tracks Deutsche Bank Long US Dollar Index (USDX) Futures Index. They also come from different issuers: Direxion and Invesco. Their fees differ too: 1.08% for CURE and 0.75% for UUP.

Which has better risk-adjusted returns?

UUP currently has the higher Sharpe Ratio (1.11 vs 0.60), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.