CSCO vs. ANAB

Last updated Jun 20, 2026

CSCO (Cisco Systems, Inc.) and ANAB (AnaptysBio, Inc.) are both stocks. CSCO operates in Communication Equipment (Technology), while ANAB operates in Biotechnology (Healthcare). Over the past 5 years, CSCO returned 21.51%/yr vs 28.81%/yr for ANAB. At a 0.21 correlation, their price movements are largely independent.

Performance

CSCO vs. ANAB - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cisco Systems, Inc. (CSCO) and AnaptysBio, Inc. (ANAB). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CSCO achieves a 56.86% return, which is significantly lower than ANAB's 77.94% return.

CSCO

• 1D: 1.88%
• 1M: -0.72%
• YTD: 56.86%
• 6M: 54.08%
• 1Y: 84.40%
• 3Y*: 35.62%
• 5Y*: 21.51%
• 10Y*: 18.83%

ANAB

• 1D: 1.30%
• 1M: -3.68%
• YTD: 77.94%
• 6M: 75.76%
• 1Y: 272.31%
• 3Y*: 66.32%
• 5Y*: 28.81%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CSCO vs. ANAB - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CSCO Cisco Systems, Inc.	56.86%	33.47%	21.00%	9.30%	-22.46%	45.76%	-3.49%	13.81%	16.57%	28.12%
ANAB AnaptysBio, Inc.	77.94%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	32.31%	-74.53%	-36.67%	529.50%

Correlation

The correlation between CSCO and ANAB is 0.10, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.10
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (5Y) Calculated over the trailing 5-year period	0.17
Correlation (All Time) Calculated using the full available price history since Jan 26, 2017	0.21

The correlation between CSCO and ANAB shifts across timeframes, from 0.10 (1 year) to 0.21 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap CSCO : $476.61B ANAB : $1.65B
EPS CSCO : $3.00 ANAB : -$0.91
PS Ratio CSCO : 7.85 ANAB : 7.29
PB Ratio CSCO : 9.75 ANAB : 129.44
Total Revenue (TTM) CSCO : $60.75B ANAB : $232.39M
Gross Profit (TTM) CSCO : $39.08B ANAB : $245.59M
EBITDA (TTM) CSCO : $13.98B ANAB : $52.72M

Return for Risk

CSCO vs. ANAB — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CSCO

CSCO Risk / Return Rank: 94
CSCO Sharpe Ratio Rank: 94
CSCO Sortino Ratio Rank: 92
CSCO Omega Ratio Rank: 94
CSCO Calmar Ratio Rank: 95
CSCO Martin Ratio Rank: 95

ANAB

ANAB Risk / Return Rank: 96
ANAB Sharpe Ratio Rank: 98
ANAB Sortino Ratio Rank: 95
ANAB Omega Ratio Rank: 95
ANAB Calmar Ratio Rank: 97
ANAB Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CSCO vs. ANAB - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cisco Systems, Inc. (CSCO) and AnaptysBio, Inc. (ANAB). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CSCO	ANAB	Difference
Sharpe ratio: Return per unit of total volatility	2.79	3.92	-1.13
Sortino ratio: Return per unit of downside risk	3.34	4.03	-0.69
Omega ratio: Gain probability vs. loss probability	1.51	1.54	-0.03
Calmar ratio: Return relative to maximum drawdown	6.35	9.62	-3.27
Martin ratio: Return relative to average drawdown	17.05	22.85	-5.80

CSCO vs. ANAB - Sharpe Ratio Comparison

The current CSCO Sharpe Ratio is 2.79, which is comparable to the ANAB Sharpe Ratio of 3.92. The chart below compares the historical Sharpe Ratios of CSCO and ANAB, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CSCO vs. ANAB - Drawdown Comparison

The maximum CSCO drawdown since its inception was -89.26%, roughly equal to the maximum ANAB drawdown of -92.08%. Use the drawdown chart below to compare losses from any high point for CSCO and ANAB.

Drawdown Indicators

	CSCO	ANAB	Difference
Max Drawdown Largest peak-to-trough decline	-89.26%	-92.08%	+2.82%
Max Drawdown (1Y) Largest decline over 1 year	-13.57%	-28.15%	+14.58%
Max Drawdown (3Y) Largest decline over 3 years	-20.16%	-69.32%	+49.16%
Max Drawdown (5Y) Largest decline over 5 years	-36.68%	-69.32%	+32.64%
Max Drawdown (10Y) Largest decline over 10 years	-41.95%	—	—
Current Drawdown Current decline from peak	-8.05%	-32.89%	+24.84%
Average Drawdown Average peak-to-trough decline	-40.10%	-64.58%	+24.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.05%	11.83%	-6.78%

Volatility

CSCO vs. ANAB - Volatility Comparison

Cisco Systems, Inc. (CSCO) and AnaptysBio, Inc. (ANAB) have volatilities of 11.87% and 12.25%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CSCO	ANAB	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.87%	12.25%	-0.38%
Volatility (6M) Calculated over the trailing 6-month period	27.29%	46.71%	-19.42%
Volatility (1Y) Calculated over the trailing 1-year period	30.94%	69.09%	-38.15%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.89%	65.38%	-40.49%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.90%	75.41%	-49.51%

Dividends

CSCO vs. ANAB - Dividend Comparison

CSCO's dividend yield for the trailing twelve months is around 1.38%, while ANAB has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ANAB AnaptysBio, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
CSCO Cisco Systems, Inc.	1.38%	2.12%	2.69%	3.07%	3.17%	2.32%	3.20%	2.88%	2.95%	2.95%	3.28%	3.02%

Financials

Frequently Asked Questions

Can I hold both CSCO and ANAB in my portfolio?

CSCO and ANAB have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CSCO or ANAB?

ANAB has higher volatility (12.25%) compared to CSCO (11.87%). In terms of maximum drawdown, CSCO dropped -89.26% vs ANAB's -92.08%.

Which has better risk-adjusted returns?

ANAB currently has the higher Sharpe Ratio (3.92 vs 2.79), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.