CNTA vs. UP

Last updated Jul 11, 2026

CNTA (Centessa Pharmaceuticals Limited) and UP (Wheels Up Experience Inc.) are both stocks. CNTA operates in Biotechnology (Healthcare), while UP operates in Airports & Air Services (Industrials). Over the past 5 years, CNTA returned 10.58%/yr vs -66.97%/yr for UP. At a 0.13 correlation, their price movements are largely independent.

Performance

CNTA vs. UP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Centessa Pharmaceuticals Limited (CNTA) and Wheels Up Experience Inc. (UP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CNTA achieves a 61.94% return, which is significantly higher than UP's -41.03% return.

CNTA

• 1D: 0.00%
• 1M: 1.96%
• 6M: 80.64%
• YTD: 61.94%
• 1Y: 180.67%
• 3Y*: 80.39%
• 5Y*: 10.58%
• 10Y*: —

UP

• 1D: -1.65%
• 1M: -6.07%
• 6M: -42.75%
• YTD: -41.03%
• 1Y: -75.81%
• 3Y*: -35.47%
• 5Y*: -66.97%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CNTA vs. UP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
CNTA Centessa Pharmaceuticals Limited	61.94%	49.31%	110.43%	156.77%	-72.47%	-44.40%
UP Wheels Up Experience Inc.	-41.03%	-60.22%	-51.90%	-66.70%	-77.80%	-53.55%

Correlation

The correlation between CNTA and UP is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.08
Correlation (3Y) Calculated over the trailing 3-year period	0.14
Correlation (5Y) Calculated over the trailing 5-year period	0.13
Correlation (All Time) Calculated using the full available price history since May 28, 2021	0.13

Fundamentals

EPS CNTA : -$1.81 UP : -$7.78
PS Ratio CNTA : 362.24 UP : 0.38
Total Revenue (TTM) CNTA : $15.00M UP : $727.89M
Gross Profit (TTM) CNTA : $15.00M UP : $27.38M
EBITDA (TTM) CNTA : -$227.27M UP : -$176.99M

Return for Risk

CNTA vs. UP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CNTA

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

UP

UP Risk / Return Rank: 20
UP Sharpe Ratio Rank: 20
UP Sortino Ratio Rank: 21
UP Omega Ratio Rank: 23
UP Calmar Ratio Rank: 13
UP Martin Ratio Rank: 22

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CNTA vs. UP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Centessa Pharmaceuticals Limited (CNTA) and Wheels Up Experience Inc. (UP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CNTA	UP	Difference
Sharpe ratio: Return per unit of total volatility	3.12	-0.56	+3.67
Sortino ratio: Return per unit of downside risk	5.09	-0.57	+5.66
Omega ratio: Gain probability vs. loss probability	1.67	0.94	+0.74
Calmar ratio: Return relative to maximum drawdown	7.69	-0.80	+8.50
Martin ratio: Return relative to average drawdown	21.44	-1.05	+22.49

CNTA vs. UP - Sharpe Ratio Comparison

The current CNTA Sharpe Ratio is 3.12, which is higher than the UP Sharpe Ratio of -0.56. The chart below compares the historical Sharpe Ratios of CNTA and UP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CNTA vs. UP - Drawdown Comparison

The maximum CNTA drawdown since its inception was -88.19%, smaller than the maximum UP drawdown of -99.78%. Use the drawdown chart below to compare losses from any high point for CNTA and UP.

Drawdown Indicators

	CNTA	UP	Difference
Max Drawdown Largest peak-to-trough decline	-88.19%	-99.78%	+11.59%
Max Drawdown (1Y) Largest decline over 1 year	-26.38%	-92.39%	+66.01%
Max Drawdown (3Y) Largest decline over 3 years	-43.72%	-95.63%	+51.91%
Max Drawdown (5Y) Largest decline over 5 years	-86.89%	-99.78%	+12.89%
Current Drawdown Current decline from peak	0.00%	-99.66%	+99.66%
Average Drawdown Average peak-to-trough decline	-51.46%	-79.17%	+27.71%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.45%	70.36%	-60.91%

Volatility

CNTA vs. UP - Volatility Comparison

The current volatility for Centessa Pharmaceuticals Limited (CNTA) is 1.20%, while Wheels Up Experience Inc. (UP) has a volatility of 29.16%. This indicates that CNTA experiences smaller price fluctuations and is considered to be less risky than UP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CNTA	UP	Difference
Volatility (1M) Calculated over the trailing 1-month period	1.20%	29.16%	-27.96%
Volatility (6M) Calculated over the trailing 6-month period	42.79%	97.55%	-54.76%
Volatility (1Y) Calculated over the trailing 1-year period	65.38%	134.00%	-68.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	71.64%	121.83%	-50.19%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	72.01%	114.84%	-42.83%

Dividends

CNTA vs. UP - Dividend Comparison

Neither CNTA nor UP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CNTA and UP in my portfolio?

CNTA and UP have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CNTA or UP?

UP has higher volatility (29.16%) compared to CNTA (1.20%). In terms of maximum drawdown, CNTA dropped -88.19% vs UP's -99.78%.

Which has better risk-adjusted returns?

CNTA currently has the higher Sharpe Ratio (3.12 vs -0.56), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.