CANC vs. PBPH

Last updated Jun 24, 2026

CANC (Tema Oncology ETF) and PBPH (Portfolio Building Block World Pharma and Biotech Index ETF) are both Health & Biotech Equities funds. CANC is actively managed, while PBPH is passively managed. A 0.74 correlation means they provide meaningful diversification when combined. CANC charges 0.75%/yr vs 0.13%/yr for PBPH.

Performance

CANC vs. PBPH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema Oncology ETF (CANC) and Portfolio Building Block World Pharma and Biotech Index ETF (PBPH). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CANC achieves a 11.49% return, which is significantly higher than PBPH's 2.63% return.

CANC

• 1D: 1.64%
• 1M: 1.56%
• YTD: 11.49%
• 6M: 9.19%
• 1Y: 56.88%
• 3Y*: 132.65%
• 5Y*: —
• 10Y*: —

PBPH

• 1D: 1.41%
• 1M: 0.87%
• YTD: 2.63%
• 6M: 2.11%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CANC vs. PBPH - Yearly Performance Comparison

	2026 (YTD)	2025
CANC Tema Oncology ETF	11.49%	-0.51%
PBPH Portfolio Building Block World Pharma and Biotech Index ETF	2.63%	0.74%

Correlation

The correlation between CANC and PBPH is 0.74, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (All Time) Calculated using the full available price history since Nov 25, 2025	0.74

Return for Risk

CANC vs. PBPH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 85
CANC Sharpe Ratio Rank: 85
CANC Sortino Ratio Rank: 86
CANC Omega Ratio Rank: 74
CANC Calmar Ratio Rank: 93
CANC Martin Ratio Rank: 85

PBPH

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CANC vs. PBPH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema Oncology ETF (CANC) and Portfolio Building Block World Pharma and Biotech Index ETF (PBPH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CANC	PBPH	Difference
Sharpe ratio: Return per unit of total volatility	2.52	—	—
Sortino ratio: Return per unit of downside risk	3.54	—	—
Omega ratio: Gain probability vs. loss probability	1.40	—	—
Calmar ratio: Return relative to maximum drawdown	6.15	—	—
Martin ratio: Return relative to average drawdown	16.71	—	—

Drawdowns

CANC vs. PBPH - Drawdown Comparison

The maximum CANC drawdown since its inception was -97.53%, which is greater than PBPH's maximum drawdown of -11.10%. Use the drawdown chart below to compare losses from any high point for CANC and PBPH.

Drawdown Indicators

	CANC	PBPH	Difference
Max Drawdown Largest peak-to-trough decline	-97.53%	-11.10%	-86.43%
Max Drawdown (1Y) Largest decline over 1 year	-9.30%	—	—
Max Drawdown (3Y) Largest decline over 3 years	-30.27%	—	—
Current Drawdown Current decline from peak	-53.78%	-5.21%	-48.57%
Average Drawdown Average peak-to-trough decline	-72.94%	-4.36%	-68.58%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.41%	—	—

Volatility

Volatility by Period

	CANC	PBPH	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.60%	—	—
Volatility (6M) Calculated over the trailing 6-month period	16.94%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	22.72%	17.07%	+5.65%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	278.65%	17.07%	+261.58%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	278.65%	17.07%	+261.58%

CANC vs. PBPH - Expense Ratio Comparison

CANC has a 0.75% expense ratio, which is higher than PBPH's 0.13% expense ratio.

Dividends

CANC vs. PBPH - Dividend Comparison

CANC's dividend yield for the trailing twelve months is around 0.05%, less than PBPH's 0.09% yield.

Position	TTM	2025	2024	2023
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%
PBPH Portfolio Building Block World Pharma and Biotech Index ETF	0.09%	0.09%	0.00%	0.00%

Frequently Asked Questions

Can I hold both CANC and PBPH in my portfolio?

CANC and PBPH have a correlation of 0.74, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, CANC or PBPH?

On fees, PBPH is cheaper at 0.13% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, CANC or PBPH?

PBPH is cheaper with a 0.13% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, CANC or PBPH?

PBPH has the higher dividend yield at 0.09%, compared with 0.05% for CANC.

What is the main difference between CANC and PBPH?

They also come from different issuers: Tema and Portfolio Building Block. Their fees differ too: 0.75% for CANC and 0.13% for PBPH.