BTAI vs. OPK

Last updated Jun 3, 2026

BTAI (BioXcel Therapeutics, Inc.) and OPK (OPKO Health, Inc.) are both stocks. Both are in the Healthcare sector — BTAI in Biotechnology, OPK in Diagnostics & Research. Over the past 5 years, BTAI returned -70.84%/yr vs -17.53%/yr for OPK. At a 0.26 correlation, their price movements are largely independent.

Performance

BTAI vs. OPK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in BioXcel Therapeutics, Inc. (BTAI) and OPKO Health, Inc. (OPK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BTAI achieves a -25.62% return, which is significantly lower than OPK's 11.11% return.

BTAI

• 1D: 0.00%
• 1M: -0.83%
• YTD: -25.62%
• 6M: -36.36%
• 1Y: -9.85%
• 3Y*: -84.22%
• 5Y*: -70.84%
• 10Y*: —

OPK

• 1D: 0.00%
• 1M: 27.27%
• YTD: 11.11%
• 6M: 5.26%
• 1Y: 1.45%
• 3Y*: -1.16%
• 5Y*: -17.53%
• 10Y*: -17.86%

*Multi-year figures are annualized to reflect compound growth (CAGR)

BTAI vs. OPK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
BTAI BioXcel Therapeutics, Inc.	-25.62%	-73.25%	-87.33%	-86.27%	5.66%	-56.00%	216.22%	278.50%	-65.00%
OPK OPKO Health, Inc.	11.11%	-14.29%	-2.65%	20.80%	-74.01%	21.77%	168.71%	-51.16%	-9.34%

Correlation

The correlation between BTAI and OPK is 0.15, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.15
Correlation (3Y) Calculated over the trailing 3-year period	0.16
Correlation (5Y) Calculated over the trailing 5-year period	0.26
Correlation (All Time) Calculated using the full available price history since Mar 9, 2018	0.26

The correlation between BTAI and OPK shifts across timeframes, from 0.15 (1 year) to 0.26 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap BTAI : $28.05M OPK : $1.06B
EPS BTAI : -$5.21 OPK : -$0.29
PS Ratio BTAI : 25.30 OPK : 1.79
Total Revenue (TTM) BTAI : $680.00K OPK : $581.17M
Gross Profit (TTM) BTAI : $175.00K OPK : $277.22M
EBITDA (TTM) BTAI : -$61.68M OPK : -$65.07M

Return for Risk

BTAI vs. OPK — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

BTAI

BTAI Risk / Return Rank: 45
BTAI Sharpe Ratio Rank: 37
BTAI Sortino Ratio Rank: 56
BTAI Omega Ratio Rank: 52
BTAI Calmar Ratio Rank: 40
BTAI Martin Ratio Rank: 40

OPK

OPK Risk / Return Rank: 40
OPK Sharpe Ratio Rank: 42
OPK Sortino Ratio Rank: 37
OPK Omega Ratio Rank: 36
OPK Calmar Ratio Rank: 43
OPK Martin Ratio Rank: 42

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

BTAI vs. OPK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for BioXcel Therapeutics, Inc. (BTAI) and OPKO Health, Inc. (OPK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	BTAI	OPK	Difference
Sharpe ratio Return per unit of total volatility	-0.07	0.04	-0.11
Sortino ratio Return per unit of downside risk	1.09	0.34	+0.75
Omega ratio Gain probability vs. loss probability	1.12	1.04	+0.08
Calmar ratio Return relative to maximum drawdown	0.01	0.10	-0.09
Martin ratio Return relative to average drawdown	0.01	0.17	-0.16
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

BTAI vs. OPK - Sharpe Ratio Comparison

The current BTAI Sharpe Ratio is -0.07, which is lower than the OPK Sharpe Ratio of 0.04. The chart below compares the historical Sharpe Ratios of BTAI and OPK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	BTAI	OPK	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.07	0.04	-0.11
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.59	-0.31	-0.27
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.28	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.39	-0.05	-0.34

Drawdowns

BTAI vs. OPK - Drawdown Comparison

The maximum BTAI drawdown since its inception was -99.90%, roughly equal to the maximum OPK drawdown of -98.17%. Use the drawdown chart below to compare losses from any high point for BTAI and OPK.

Drawdown Indicators

	BTAI	OPK	Difference
Max Drawdown Largest peak-to-trough decline	-99.90%	-98.17%	-1.73%
Max Drawdown (1Y) Largest decline over 1 year	-85.00%	-30.38%	-54.62%
Max Drawdown (3Y) Largest decline over 3 years	-99.70%	-60.12%	-39.58%
Max Drawdown (5Y) Largest decline over 5 years	-99.84%	-83.19%	-16.65%
Max Drawdown (10Y) Largest decline over 10 years	—	-92.73%	—
Current Drawdown Current decline from peak	-99.88%	-92.68%	-7.20%
Average Drawdown Average peak-to-trough decline	-63.17%	-73.09%	+9.92%
Ulcer Index Depth and duration of drawdowns from previous peaks	64.21%	16.82%	+47.39%

Volatility

BTAI vs. OPK - Volatility Comparison

BioXcel Therapeutics, Inc. (BTAI) has a higher volatility of 18.67% compared to OPKO Health, Inc. (OPK) at 13.60%. This indicates that BTAI's price experiences larger fluctuations and is considered to be riskier than OPK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BTAI	OPK	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.67%	13.60%	+5.07%
Volatility (6M) Calculated over the trailing 6-month period	56.37%	26.76%	+29.61%
Volatility (1Y) Calculated over the trailing 1-year period	144.26%	37.54%	+106.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	121.38%	56.43%	+64.95%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	117.98%	64.77%	+53.21%

Dividends

BTAI vs. OPK - Dividend Comparison

Neither BTAI nor OPK has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both BTAI and OPK in my portfolio?

BTAI and OPK have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, BTAI or OPK?

BTAI has higher volatility (18.67%) compared to OPK (13.60%). In terms of maximum drawdown, BTAI dropped -99.90% vs OPK's -98.17%.

Which has better risk-adjusted returns?

OPK currently has the higher Sharpe Ratio (0.04 vs -0.07), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.