ANIP vs. INVA

Last updated Jun 23, 2026

ANIP (ANI Pharmaceuticals, Inc.) and INVA (Innoviva, Inc.) are both stocks. Both are in the Healthcare sector — ANIP in Drug Manufacturers - Specialty & Generic, INVA in Biotechnology. Over the past 10 years, ANIP returned 4.02%/yr vs 8.19%/yr for INVA. At a 0.24 correlation, their price movements are largely independent.

Performance

ANIP vs. INVA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ANI Pharmaceuticals, Inc. (ANIP) and Innoviva, Inc. (INVA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ANIP achieves a 2.08% return, which is significantly lower than INVA's 13.41% return. Over the past 10 years, ANIP has underperformed INVA with an annualized return of 4.02%, while INVA has yielded a comparatively higher 8.19% annualized return.

ANIP

• 1D: 1.37%
• 1M: -2.59%
• YTD: 2.08%
• 6M: -0.17%
• 1Y: 22.91%
• 3Y*: 15.92%
• 5Y*: 19.64%
• 10Y*: 4.02%

INVA

• 1D: 0.80%
• 1M: 0.93%
• YTD: 13.41%
• 6M: 13.41%
• 1Y: 7.95%
• 3Y*: 21.53%
• 5Y*: 11.34%
• 10Y*: 8.19%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ANIP vs. INVA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ANIP ANI Pharmaceuticals, Inc.	2.08%	42.80%	0.25%	37.06%	-12.70%	58.68%	-52.91%	36.98%	-30.15%	6.32%
INVA Innoviva, Inc.	13.41%	15.22%	8.17%	21.06%	-23.19%	39.23%	-12.50%	-18.85%	22.97%	32.62%

Correlation

The correlation between ANIP and INVA is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.25
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.27
Correlation (10Y) Calculated over the trailing 10-year period	0.30
Correlation (All Time) Calculated using the full available price history since Oct 5, 2004	0.24

Fundamentals

Market Cap ANIP : $1.74B INVA : $1.92B
EPS ANIP : $4.26 INVA : $5.94
PE Ratio ANIP : 18.91 INVA : 3.82
PEG Ratio ANIP : 0.13 INVA : 0.02
PS Ratio ANIP : 1.84 INVA : 4.54
PB Ratio ANIP : 3.09 INVA : 1.33
Total Revenue (TTM) ANIP : $923.71M INVA : $424.12M
Gross Profit (TTM) ANIP : $486.11M INVA : $323.16M
EBITDA (TTM) ANIP : $234.71M INVA : $438.91M

Return for Risk

ANIP vs. INVA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ANIP

ANIP Risk / Return Rank: 60
ANIP Sharpe Ratio Rank: 63
ANIP Sortino Ratio Rank: 63
ANIP Omega Ratio Rank: 59
ANIP Calmar Ratio Rank: 60
ANIP Martin Ratio Rank: 58

INVA

INVA Risk / Return Rank: 50
INVA Sharpe Ratio Rank: 52
INVA Sortino Ratio Rank: 48
INVA Omega Ratio Rank: 46
INVA Calmar Ratio Rank: 52
INVA Martin Ratio Rank: 53

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ANIP vs. INVA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ANI Pharmaceuticals, Inc. (ANIP) and Innoviva, Inc. (INVA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ANIP	INVA	Difference
Sharpe ratio: Return per unit of total volatility	0.65	0.28	+0.37
Sortino ratio: Return per unit of downside risk	1.33	0.70	+0.63
Omega ratio: Gain probability vs. loss probability	1.15	1.08	+0.07
Calmar ratio: Return relative to maximum drawdown	0.80	0.39	+0.41
Martin ratio: Return relative to average drawdown	1.48	0.92	+0.56

ANIP vs. INVA - Sharpe Ratio Comparison

The current ANIP Sharpe Ratio is 0.65, which is higher than the INVA Sharpe Ratio of 0.28. The chart below compares the historical Sharpe Ratios of ANIP and INVA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ANIP vs. INVA - Drawdown Comparison

The maximum ANIP drawdown since its inception was -98.81%, which is greater than INVA's maximum drawdown of -84.32%. Use the drawdown chart below to compare losses from any high point for ANIP and INVA.

Drawdown Indicators

	ANIP	INVA	Difference
Max Drawdown Largest peak-to-trough decline	-98.81%	-84.32%	-14.49%
Max Drawdown (1Y) Largest decline over 1 year	-28.66%	-20.32%	-8.34%
Max Drawdown (3Y) Largest decline over 3 years	-28.66%	-23.53%	-5.13%
Max Drawdown (5Y) Largest decline over 5 years	-59.38%	-47.01%	-12.37%
Max Drawdown (10Y) Largest decline over 10 years	-72.96%	-59.57%	-13.39%
Current Drawdown Current decline from peak	-82.09%	-29.11%	-52.98%
Average Drawdown Average peak-to-trough decline	-79.39%	-44.68%	-34.71%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.54%	8.85%	+6.69%

Volatility

ANIP vs. INVA - Volatility Comparison

ANI Pharmaceuticals, Inc. (ANIP) has a higher volatility of 9.06% compared to Innoviva, Inc. (INVA) at 6.62%. This indicates that ANIP's price experiences larger fluctuations and is considered to be riskier than INVA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ANIP	INVA	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.06%	6.62%	+2.44%
Volatility (6M) Calculated over the trailing 6-month period	24.48%	17.05%	+7.43%
Volatility (1Y) Calculated over the trailing 1-year period	35.60%	28.92%	+6.68%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	46.33%	27.29%	+19.04%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	48.20%	33.86%	+14.34%

Dividends

ANIP vs. INVA - Dividend Comparison

Neither ANIP nor INVA has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ANIP ANI Pharmaceuticals, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
INVA Innoviva, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	7.12%

Financials

Frequently Asked Questions

Can I hold both ANIP and INVA in my portfolio?

ANIP and INVA have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ANIP or INVA?

ANIP has higher volatility (9.06%) compared to INVA (6.62%). In terms of maximum drawdown, ANIP dropped -98.81% vs INVA's -84.32%.

Which has better risk-adjusted returns?

ANIP currently has the higher Sharpe Ratio (0.65 vs 0.28), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.