ANAB vs. CSCO

Last updated Aug 1, 2026

ANAB (AnaptysBio, Inc.) and CSCO (Cisco Systems, Inc.) are both stocks. ANAB operates in Biotechnology (Healthcare), while CSCO operates in Communication Equipment (Technology). Over the past 5 years, ANAB returned 28.35%/yr vs 19.23%/yr for CSCO. Their 0.21 correlation means their historical movements had little consistent relationship.

Performance

ANAB vs. CSCO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AnaptysBio, Inc. (ANAB) and Cisco Systems, Inc. (CSCO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ANAB achieves a 65.10% return, which is significantly higher than CSCO's 52.77% return.

ANAB

• 1D: -3.05%
• 1M: -18.45%
• 6M: 68.83%
• YTD: 65.10%
• 1Y: 226.03%
• 3Y*: 57.31%
• 5Y*: 28.35%
• 10Y*: —
• ALL TIME*: 18.45%

CSCO

• 1D: 2.14%
• 1M: -0.50%
• 6M: 49.46%
• YTD: 52.77%
• 1Y: 73.90%
• 3Y*: 33.59%
• 5Y*: 19.23%
• 10Y*: 17.69%
• ALL TIME*: 23.57%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ANAB AnaptysBio, Inc.	$39.97M	$46.98M	$40.05M
CSCO Cisco Systems, Inc.	$2.18B	$2.38B	$2.92B

ANAB vs. CSCO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ANAB AnaptysBio, Inc.	65.10%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	32.31%	-74.53%	-36.67%	529.50%
CSCO Cisco Systems, Inc.	52.77%	33.47%	21.00%	9.30%	-22.46%	45.76%	-3.49%	13.81%	16.57%	28.12%

Correlation

The correlation between ANAB and CSCO is 0.13, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.13
Correlation (3Y) Balances recent behavior with more history.	0.15
Correlation (5Y) Shows whether the relationship held over a longer period.	0.17
Correlation (All Time) Calculated using the full available price history since Jan 26, 2017	0.21

Fundamentals

Market Cap ANAB : $2.30B CSCO : $457.17B
EPS ANAB : -$0.90 CSCO : $3.00
PS Ratio ANAB : 6.82 CSCO : 7.62
PB Ratio ANAB : 120.10 CSCO : 9.46
Total Revenue (TTM) ANAB : $232.39M CSCO : $60.75B
Gross Profit (TTM) ANAB : $245.59M CSCO : $39.08B
EBITDA (TTM) ANAB : $52.72M CSCO : $13.98B

Return for Risk

ANAB vs. CSCO — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ANAB

ANAB Risk / Return Rank: 96
ANAB Sharpe Ratio Rank: 98
ANAB Sortino Ratio Rank: 94
ANAB Omega Ratio Rank: 94
ANAB Calmar Ratio Rank: 98
ANAB Martin Ratio Rank: 97

CSCO

CSCO Risk / Return Rank: 93
CSCO Sharpe Ratio Rank: 94
CSCO Sortino Ratio Rank: 91
CSCO Omega Ratio Rank: 93
CSCO Calmar Ratio Rank: 95
CSCO Martin Ratio Rank: 93

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ANAB vs. CSCO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AnaptysBio, Inc. (ANAB) and Cisco Systems, Inc. (CSCO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ANAB	CSCO	Difference
Sharpe ratio: Return per unit of total volatility	3.10	2.27	+0.83
Sortino ratio: Return per unit of downside risk	3.35	2.80	+0.55
Omega ratio: Gain probability vs. loss probability	1.45	1.40	+0.04
Calmar ratio: Return relative to maximum drawdown	8.14	4.85	+3.29
Martin ratio: Return relative to average drawdown	19.84	11.72	+8.12

ANAB vs. CSCO - Sharpe Ratio Comparison

The current ANAB Sharpe Ratio is 3.10, which is higher than the CSCO Sharpe Ratio of 2.27. The chart below compares the historical Sharpe Ratios of ANAB and CSCO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ANAB vs. CSCO - Drawdown Comparison

The maximum ANAB drawdown since its inception was -92.08%, roughly equal to the maximum CSCO drawdown of -89.26%. Use the drawdown chart below to compare losses from any high point for ANAB and CSCO.

Drawdown Indicators

	ANAB	CSCO	Difference
Max Drawdown Largest peak-to-trough decline	-92.08%	-89.26%	-2.82%
Max Drawdown (1Y) Largest decline over 1 year	-27.96%	-15.33%	-12.63%
Max Drawdown (3Y) Largest decline over 3 years	-69.32%	-20.16%	-49.16%
Max Drawdown (5Y) Largest decline over 5 years	-69.32%	-36.68%	-32.64%
Max Drawdown (10Y) Largest decline over 10 years	—	-41.95%	—
Current Drawdown Current decline from peak	-37.74%	-10.44%	-27.30%
Average Drawdown Average peak-to-trough decline	-64.17%	-40.01%	-24.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.45%	6.33%	+5.12%

Volatility

ANAB vs. CSCO - Volatility Comparison

AnaptysBio, Inc. (ANAB) has a higher volatility of 27.46% compared to Cisco Systems, Inc. (CSCO) at 10.19%. This indicates that ANAB's price experiences larger fluctuations and is considered to be riskier than CSCO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ANAB	CSCO	Difference
Volatility (1M) Calculated over the trailing 1-month period	27.46%	10.19%	+17.27%
Volatility (6M) Calculated over the trailing 6-month period	51.26%	29.00%	+22.26%
Volatility (1Y) Calculated over the trailing 1-year period	73.55%	32.79%	+40.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	66.36%	25.35%	+41.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	75.51%	26.07%	+49.44%

Dividends

ANAB vs. CSCO - Dividend Comparison

ANAB has not paid dividends to shareholders, while CSCO's dividend yield for the trailing twelve months is around 1.43%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ANAB AnaptysBio, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
CSCO Cisco Systems, Inc.	1.43%	2.12%	2.69%	3.07%	3.17%	2.32%	3.20%	2.88%	2.95%	2.95%	3.28%	3.02%

Financials

Frequently Asked Questions

Can I hold both ANAB and CSCO in my portfolio?

ANAB and CSCO have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ANAB or CSCO?

ANAB has higher volatility (27.46%) compared to CSCO (10.19%). In terms of maximum drawdown, ANAB dropped -92.08% vs CSCO's -89.26%.

Which has better risk-adjusted returns?

ANAB currently has the higher Sharpe Ratio (3.10 vs 2.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.