ALNY vs. MCK
ALNY (Alnylam Pharmaceuticals, Inc.) and MCK (McKesson Corporation) are both stocks. Both are in the Healthcare sector — ALNY in Biotechnology, MCK in Medical Distribution. Over the past 10 years, ALNY returned 11.28%/yr vs 16.92%/yr for MCK. Their 0.23 correlation means their historical movements had little consistent relationship.
Performance
ALNY vs. MCK - Performance Comparison
Loading charts...
Returns By Period
In the year-to-date period, ALNY achieves a -48.32% return, which is significantly lower than MCK's 4.58% return. Over the past 10 years, ALNY has underperformed MCK with an annualized return of 11.28%, while MCK has yielded a comparatively higher 16.92% annualized return.
ALNY
- 1D
- 0.02%
- 1M
- -34.29%
- 6M
- -39.21%
- YTD
- -48.32%
- 1Y
- -48.85%
- 3Y*
- 2.82%
- 5Y*
- 2.81%
- 10Y*
- 11.28%
- ALL TIME*
- 17.20%
MCK
- 1D
- -1.08%
- 1M
- 8.89%
- 6M
- 3.20%
- YTD
- 4.58%
- 1Y
- 23.02%
- 3Y*
- 28.93%
- 5Y*
- 33.97%
- 10Y*
- 16.92%
- ALL TIME*
- 14.34%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $567.18M | $557.43M | $409.61M | |
| $753.55M | $770.00M | $919.20M |
ALNY vs. MCK - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
ALNY Alnylam Pharmaceuticals, Inc. | -48.32% | 68.99% | 22.94% | -19.46% | 40.14% | 30.48% | 12.85% | 57.96% | -42.61% | 239.34% |
MCK McKesson Corporation | 4.58% | 44.54% | 23.67% | 24.13% | 51.82% | 44.23% | 27.06% | 26.72% | -28.40% | 11.95% |
Correlation
The correlation between ALNY and MCK is 0.11, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.11 |
Correlation (3Y) Balances recent behavior with more history. | 0.04 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.08 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.15 |
Correlation (All Time) Calculated using the full available price history since Jun 1, 2004 | 0.23 |
The correlation between ALNY and MCK shifts across timeframes, from 0.04 (3 years) to 0.23 (all time), reflecting how their relationship changes across market environments.
Fundamentals
ALNY:
$27.44B
MCK:
$100.24B
ALNY:
$5.88
MCK:
$38.53
ALNY:
34.98
MCK:
22.22
ALNY:
5.88
MCK:
0.26
ALNY:
20.98
MCK:
15.19
ALNY:
$4.80B
MCK:
$403.43B
ALNY:
$1.88B
MCK:
$14.55B
ALNY:
$822.65M
MCK:
$6.91B
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Return for Risk
ALNY vs. MCK — Risk / Return Rank
ALNY
MCK
ALNY vs. MCK - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Alnylam Pharmaceuticals, Inc. (ALNY) and McKesson Corporation (MCK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| ALNY | MCK | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.85 | ||
| Sortino ratioReturn per unit of downside risk | -2.80 | ||
| Omega ratioGain probability vs. loss probability | 0.78 | 1.18 | -0.40 |
| Calmar ratioReturn relative to maximum drawdown | -0.82 | 0.89 | -1.71 |
| Martin ratioReturn relative to average drawdown | -1.68 | 1.94 | -3.62 |
Loading charts...
Drawdowns
ALNY vs. MCK - Drawdown Comparison
The maximum ALNY drawdown since its inception was -83.58%, roughly equal to the maximum MCK drawdown of -82.84%. Use the drawdown chart below to compare losses from any high point for ALNY and MCK.
Loading charts...
Drawdown Indicators
| ALNY | MCK | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -83.58% | -82.84% | -0.74% |
Max Drawdown (1Y)Largest decline over 1 year | -58.17% | -27.17% | -31.00% |
Max Drawdown (3Y)Largest decline over 3 years | -58.17% | -27.17% | -31.00% |
Max Drawdown (5Y)Largest decline over 5 years | -58.17% | -27.17% | -31.00% |
Max Drawdown (10Y)Largest decline over 10 years | -59.95% | -43.71% | -16.24% |
Current DrawdownCurrent decline from peak | -58.16% | -13.92% | -44.24% |
Average DrawdownAverage peak-to-trough decline | -30.66% | -28.60% | -2.06% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 28.31% | 12.38% | +15.93% |
Volatility
ALNY vs. MCK - Volatility Comparison
Alnylam Pharmaceuticals, Inc. (ALNY) has a higher volatility of 35.07% compared to McKesson Corporation (MCK) at 10.05%. This indicates that ALNY's price experiences larger fluctuations and is considered to be riskier than MCK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
Loading charts...
Volatility by Period
| ALNY | MCK | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 35.07% | 10.05% | +25.02% |
Volatility (6M)Calculated over the trailing 6-month period | 41.89% | 25.08% | +16.81% |
Volatility (1Y)Calculated over the trailing 1-year period | 47.33% | 30.76% | +16.57% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 50.53% | 24.58% | +25.95% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 54.28% | 28.94% | +25.34% |
Dividends
ALNY vs. MCK - Dividend Comparison
ALNY has not paid dividends to shareholders, while MCK's dividend yield for the trailing twelve months is around 0.38%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALNY Alnylam Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
MCK McKesson Corporation | 0.38% | 0.37% | 0.47% | 0.50% | 0.54% | 0.72% | 0.95% | 1.16% | 1.32% | 0.80% | 0.80% | 0.53% |
Financials
ALNY vs. MCK - Financials Comparison
This section allows you to compare key financial metrics between Alnylam Pharmaceuticals, Inc. and McKesson Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
ALNY vs. MCK - Profitability Comparison
ALNY - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Alnylam Pharmaceuticals, Inc. reported a gross profit of -956.05M and revenue of 1.29B. Therefore, the gross margin over that period was -74.1%.
MCK - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, McKesson Corporation reported a gross profit of 4.04B and revenue of 96.30B. Therefore, the gross margin over that period was 4.2%.
ALNY - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Alnylam Pharmaceuticals, Inc. reported an operating income of 231.44M and revenue of 1.29B, resulting in an operating margin of 17.9%.
MCK - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, McKesson Corporation reported an operating income of 2.09B and revenue of 96.30B, resulting in an operating margin of 2.2%.
ALNY - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Alnylam Pharmaceuticals, Inc. reported a net income of 164.49M and revenue of 1.29B, resulting in a net margin of 12.7%.
MCK - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, McKesson Corporation reported a net income of 1.68B and revenue of 96.30B, resulting in a net margin of 1.8%.
Frequently Asked Questions
ALNY and MCK have a correlation of 0.11, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ALNY has higher volatility (35.07%) compared to MCK (10.05%). In terms of maximum drawdown, ALNY dropped -83.58% vs MCK's -82.84%.
MCK currently has the higher Sharpe Ratio (0.79 vs -1.07), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
Find the right allocation for ALNY and MCK
Add both to a portfolio and optimize allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Optimizer