ALNY vs. MCK
ALNY (Alnylam Pharmaceuticals, Inc.) and MCK (McKesson Corporation) are both stocks. Both are in the Healthcare sector — ALNY in Biotechnology, MCK in Medical Distribution. Over the past 10 years, ALNY returned 16.66%/yr vs 16.10%/yr for MCK. At a 0.23 correlation, their price movements are largely independent.
Performance
ALNY vs. MCK - Performance Comparison
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Returns By Period
In the year-to-date period, ALNY achieves a -24.87% return, which is significantly lower than MCK's -1.56% return. Both investments have delivered pretty close results over the past 10 years, with ALNY having a 16.66% annualized return and MCK not far behind at 16.10%.
ALNY
- 1D
- -4.49%
- 1M
- 5.62%
- 6M
- -24.99%
- YTD
- -24.87%
- 1Y
- -5.14%
- 3Y*
- 13.91%
- 5Y*
- 11.07%
- 10Y*
- 16.66%
MCK
- 1D
- 1.66%
- 1M
- 2.79%
- 6M
- -1.05%
- YTD
- -1.56%
- 1Y
- 14.04%
- 3Y*
- 25.46%
- 5Y*
- 34.36%
- 10Y*
- 16.10%
ALNY vs. MCK - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
ALNY Alnylam Pharmaceuticals, Inc. | -24.87% | 68.99% | 22.94% | -19.46% | 40.14% | 30.48% | 12.85% | 57.96% | -42.61% | 239.34% |
MCK McKesson Corporation | -1.56% | 44.54% | 23.67% | 24.13% | 51.82% | 44.23% | 27.06% | 26.72% | -28.40% | 11.95% |
Correlation
The correlation between ALNY and MCK is 0.07, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.07 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.02 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.07 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.14 |
Correlation (All Time) Calculated using the full available price history since Jun 1, 2004 | 0.23 |
The correlation between ALNY and MCK shifts across timeframes, from 0.02 (3 years) to 0.23 (all time), reflecting how their relationship changes across market environments.
Fundamentals
ALNY:
$39.89B
MCK:
$94.36B
ALNY:
$4.20
MCK:
$38.53
ALNY:
71.06
MCK:
20.92
ALNY:
9.57
MCK:
0.25
ALNY:
38.40
MCK:
14.30
ALNY:
$4.29B
MCK:
$403.43B
ALNY:
$2.51B
MCK:
$14.55B
ALNY:
$729.86M
MCK:
$6.91B
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Return for Risk
ALNY vs. MCK — Risk / Return Rank
ALNY
MCK
ALNY vs. MCK - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Alnylam Pharmaceuticals, Inc. (ALNY) and McKesson Corporation (MCK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| ALNY | MCK | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.65 | ||
| Sortino ratioReturn per unit of downside risk | -0.93 | ||
| Omega ratioGain probability vs. loss probability | 1.00 | 1.12 | -0.12 |
| Calmar ratioReturn relative to maximum drawdown | -0.17 | 0.49 | -0.66 |
| Martin ratioReturn relative to average drawdown | -0.29 | 1.13 | -1.41 |
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Drawdowns
ALNY vs. MCK - Drawdown Comparison
The maximum ALNY drawdown since its inception was -83.58%, roughly equal to the maximum MCK drawdown of -82.84%. Use the drawdown chart below to compare losses from any high point for ALNY and MCK.
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Drawdown Indicators
| ALNY | MCK | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -83.58% | -82.84% | -0.74% |
Max Drawdown (1Y)Largest decline over 1 year | -43.39% | -27.17% | -16.22% |
Max Drawdown (3Y)Largest decline over 3 years | -43.39% | -27.17% | -16.22% |
Max Drawdown (5Y)Largest decline over 5 years | -43.39% | -27.17% | -16.22% |
Max Drawdown (10Y)Largest decline over 10 years | -59.95% | -44.23% | -15.72% |
Current DrawdownCurrent decline from peak | -39.18% | -18.97% | -20.21% |
Average DrawdownAverage peak-to-trough decline | -30.62% | -28.63% | -1.99% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 26.01% | 11.78% | +14.23% |
Volatility
ALNY vs. MCK - Volatility Comparison
Alnylam Pharmaceuticals, Inc. (ALNY) has a higher volatility of 9.95% compared to McKesson Corporation (MCK) at 8.00%. This indicates that ALNY's price experiences larger fluctuations and is considered to be riskier than MCK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| ALNY | MCK | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.95% | 8.00% | +1.95% |
Volatility (6M)Calculated over the trailing 6-month period | 26.18% | 23.87% | +2.31% |
Volatility (1Y)Calculated over the trailing 1-year period | 37.44% | 29.66% | +7.78% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 48.88% | 24.35% | +24.53% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 53.50% | 28.83% | +24.67% |
Dividends
ALNY vs. MCK - Dividend Comparison
ALNY has not paid dividends to shareholders, while MCK's dividend yield for the trailing twelve months is around 0.41%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALNY Alnylam Pharmaceuticals, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
MCK McKesson Corporation | 0.41% | 0.37% | 0.47% | 0.50% | 0.54% | 0.72% | 0.95% | 1.16% | 1.32% | 0.80% | 0.80% | 0.53% |
Financials
ALNY vs. MCK - Financials Comparison
This section allows you to compare key financial metrics between Alnylam Pharmaceuticals, Inc. and McKesson Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
ALNY vs. MCK - Profitability Comparison
ALNY - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jul 2026, Alnylam Pharmaceuticals, Inc. reported a gross profit of 0.00 and revenue of 1.17B. Therefore, the gross margin over that period was 0.0%.
MCK - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jul 2026, McKesson Corporation reported a gross profit of 4.04B and revenue of 96.30B. Therefore, the gross margin over that period was 4.2%.
ALNY - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jul 2026, Alnylam Pharmaceuticals, Inc. reported an operating income of 268.64M and revenue of 1.17B, resulting in an operating margin of 23.0%.
MCK - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jul 2026, McKesson Corporation reported an operating income of 2.09B and revenue of 96.30B, resulting in an operating margin of 2.2%.
ALNY - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jul 2026, Alnylam Pharmaceuticals, Inc. reported a net income of 205.99M and revenue of 1.17B, resulting in a net margin of 17.7%.
MCK - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jul 2026, McKesson Corporation reported a net income of 1.68B and revenue of 96.30B, resulting in a net margin of 1.8%.
Frequently Asked Questions
ALNY and MCK have a correlation of 0.07, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ALNY has higher volatility (9.95%) compared to MCK (8.00%). In terms of maximum drawdown, ALNY dropped -83.58% vs MCK's -82.84%.
MCK currently has the higher Sharpe Ratio (0.45 vs -0.20), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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