ALGN vs. ARGX

Last updated Aug 1, 2026

ALGN (Align Technology, Inc.) and ARGX (argenx SE) are both stocks. Both are in the Healthcare sector — ALGN in Medical Devices, ARGX in Biotechnology. Over the past 5 years, ALGN returned -24.64%/yr vs 22.91%/yr for ARGX. Their 0.22 correlation means their historical movements had little consistent relationship.

Performance

ALGN vs. ARGX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Align Technology, Inc. (ALGN) and argenx SE (ARGX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ALGN achieves a 8.33% return, which is significantly higher than ARGX's 1.53% return.

ALGN

• 1D: -2.45%
• 1M: -8.32%
• 6M: 3.76%
• YTD: 8.33%
• 1Y: 23.91%
• 3Y*: -23.42%
• 5Y*: -24.64%
• 10Y*: 6.47%
• ALL TIME*: 9.15%

ARGX

• 1D: -2.15%
• 1M: -9.14%
• 6M: 1.58%
• YTD: 1.53%
• 1Y: 26.72%
• 3Y*: 19.21%
• 5Y*: 22.91%
• 10Y*: —
• ALL TIME*: 52.20%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ALGN Align Technology, Inc.	$184.54M	$172.46M	$175.55M
ARGX argenx SE	$264.18M	$262.07M	$293.40M

ALGN vs. ARGX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ALGN Align Technology, Inc.	8.33%	-25.11%	-23.90%	29.92%	-67.91%	22.98%	91.51%	33.24%	-5.74%	63.28%
ARGX argenx SE	1.53%	36.74%	61.66%	0.42%	8.18%	19.08%	83.21%	67.09%	52.15%	252.74%

Correlation

The correlation between ALGN and ARGX is 0.11, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.11
Correlation (3Y) Balances recent behavior with more history.	0.10
Correlation (5Y) Shows whether the relationship held over a longer period.	0.19
Correlation (All Time) Calculated using the full available price history since May 18, 2017	0.22

The correlation between ALGN and ARGX shifts across timeframes, from 0.10 (3 years) to 0.22 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ALGN : $12.11B ARGX : $53.10B
EPS ALGN : $5.76 ARGX : $35.23
PE Ratio ALGN : 29.39 ARGX : 24.24
PS Ratio ALGN : 2.94 ARGX : 8.63
PB Ratio ALGN : 2.86 ARGX : 6.53
Total Revenue (TTM) ALGN : $4.14B ARGX : $6.46B
Gross Profit (TTM) ALGN : $2.82B ARGX : $6.96B
EBITDA (TTM) ALGN : $787.93M ARGX : $2.01B

Return for Risk

ALGN vs. ARGX — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ALGN

ALGN Risk / Return Rank: 69
ALGN Sharpe Ratio Rank: 70
ALGN Sortino Ratio Rank: 68
ALGN Omega Ratio Rank: 64
ALGN Calmar Ratio Rank: 73
ALGN Martin Ratio Rank: 72

ARGX

ARGX Risk / Return Rank: 69
ARGX Sharpe Ratio Rank: 73
ARGX Sortino Ratio Rank: 69
ARGX Omega Ratio Rank: 67
ARGX Calmar Ratio Rank: 66
ARGX Martin Ratio Rank: 68

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ALGN vs. ARGX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Align Technology, Inc. (ALGN) and argenx SE (ARGX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ALGN	ARGX	Difference
Sharpe ratio: Return per unit of total volatility	0.78	0.90	-0.12
Sortino ratio: Return per unit of downside risk	1.38	1.45	-0.07
Omega ratio: Gain probability vs. loss probability	1.16	1.17	-0.02
Calmar ratio: Return relative to maximum drawdown	1.46	0.96	+0.50
Martin ratio: Return relative to average drawdown	3.15	2.53	+0.63

ALGN vs. ARGX - Sharpe Ratio Comparison

The current ALGN Sharpe Ratio is 0.78, which is comparable to the ARGX Sharpe Ratio of 0.90. The chart below compares the historical Sharpe Ratios of ALGN and ARGX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ALGN vs. ARGX - Drawdown Comparison

The maximum ALGN drawdown since its inception was -92.83%, which is greater than ARGX's maximum drawdown of -38.20%. Use the drawdown chart below to compare losses from any high point for ALGN and ARGX.

Drawdown Indicators

	ALGN	ARGX	Difference
Max Drawdown Largest peak-to-trough decline	-92.83%	-38.20%	-54.63%
Max Drawdown (1Y) Largest decline over 1 year	-21.44%	-28.58%	+7.14%
Max Drawdown (3Y) Largest decline over 3 years	-66.69%	-35.81%	-30.88%
Max Drawdown (5Y) Largest decline over 5 years	-82.89%	-38.20%	-44.69%
Max Drawdown (10Y) Largest decline over 10 years	-82.89%	—	—
Current Drawdown Current decline from peak	-76.82%	-9.14%	-67.68%
Average Drawdown Average peak-to-trough decline	-38.16%	-11.00%	-27.16%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.89%	10.86%	-0.97%

Volatility

ALGN vs. ARGX - Volatility Comparison

The current volatility for Align Technology, Inc. (ALGN) is 11.14%, while argenx SE (ARGX) has a volatility of 12.26%. This indicates that ALGN experiences smaller price fluctuations and is considered to be less risky than ARGX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ALGN	ARGX	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.14%	12.26%	-1.12%
Volatility (6M) Calculated over the trailing 6-month period	32.23%	25.05%	+7.18%
Volatility (1Y) Calculated over the trailing 1-year period	54.35%	32.75%	+21.60%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	49.81%	38.85%	+10.96%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	49.29%	51.40%	-2.11%

Dividends

ALGN vs. ARGX - Dividend Comparison

Neither ALGN nor ARGX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ALGN and ARGX in my portfolio?

ALGN and ARGX have a correlation of 0.11, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ALGN or ARGX?

ARGX has higher volatility (12.26%) compared to ALGN (11.14%). In terms of maximum drawdown, ALGN dropped -92.83% vs ARGX's -38.20%.

Which has better risk-adjusted returns?

ARGX currently has the higher Sharpe Ratio (0.90 vs 0.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.