Simplify Propel Opportunities ETF (SURI) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with SURI. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to SURI
SURI charges 2.51% annually. There are 66 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | SURI vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | SURI vs XLV | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | SURI vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | SURI vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | SURI vs PBPH |
Best Risk-Adjusted Alternatives to SURI
SURI has a PortfoliosLab risk / return rank of 78. There are 22 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | SURI vs BBC | |
| iShares U.S. Pharmaceuticals ETF | 95 | 1.65B | May 2006 | SURI vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 95 | 911.09M | Sep 2016 | SURI vs FTXH | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | SURI vs SBIO | |
| Invesco Dynamic Pharmaceuticals ETF | 94 | 472.10M | Jun 2005 | SURI vs PJP |
Top Performing SURI Alternatives (YTD)
SURI is at 17.59% YTD. There are 17 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.76%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 36.76% | 1.73B | Oct 2014 | SURI vs ARKG | |
| AdvisorShares Psychedelics ETF | 36.69% | 48.53M | Sep 2021 | SURI vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 28.89% | 7.27M | Dec 2025 | SURI vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 27.03% | 47.80M | Dec 2014 | SURI vs BBC | |
| SPDR S&P Health Care Services ETF | 25.67% | 206.72M | Sep 2011 | SURI vs XHS |
Lowest Volatility Alternatives to SURI
SURI has 22.20% 1-year volatility. There are 43 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | SURI vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SURI vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.66% | 10.09M | Jun 2007 | SURI vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.75% | 21.55M | Jul 2025 | SURI vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 10.92% | 982.35K | Apr 2026 | SURI vs MHIP |
Lowest Drawdown Alternatives to SURI
SURI has a 1-year max drawdown of -11.78%. There are 28 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | SURI vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | SURI vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | SURI vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | SURI vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | SURI vs IBBQ |
Other ETFs from Simplify
The 10 most viewed Simplify ETFs shown here include SVOL, CTA, HEQT and span 15 categories. AUM among these funds goes as high as $2B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Simplify Volatility Premium ETF | Volatility | 42 | 1.56% | 523.04M | May 2021 | SURI vs SVOL | |
| Simplify Managed Futures Strategy ETF | Systematic Trend | 15 | -0.51% | 1.56B | Mar 2022 | SURI vs CTA | |
| Simplify Hedged Equity ETF | Equity Hedged, Options Trading, Actively Managed | 83 | 6.73% | 296.16M | Nov 2021 | SURI vs HEQT | |
| Simplify Treasury Option Income ETF | Government Bonds, Ultrashort Bond, Derivative Income | 93 | 2.60% | 489.70M | Oct 2022 | SURI vs BUCK | |
| Simplify Bitcoin Strategy PLUS Income ETF | Cryptocurrency, Derivative Income | 2 | -35.16% | 24.53M | Sep 2022 | SURI vs MAXI | |
| Simplify Interest Rate Hedge ETF | Inverse Bonds, Nontraditional Bonds | 17 | 11.17% | 182.81M | May 2021 | SURI vs PFIX | |
| Simplify High Yield ETF | High Yield Bonds | 4 | -3.19% | 377.28M | Feb 2022 | SURI vs CDX | |
| Simplify Enhanced Income ETF | Derivative Income, Dividend | 10 | 0.14% | 66.82M | Oct 2022 | SURI vs HIGH | |
| Simplify Aggregate Bond ETF | Intermediate Core Bond | 31 | -0.13% | 574.10M | Feb 2022 | SURI vs AGGH | |
| Simplify MBS ETF | Mortgage Backed Securities | 33 | -0.45% | 1.49B | Nov 2023 | SURI vs MTBA |
Often Compared With SURI
Investors most often compare SURI with AIPI, PEX, LIFE.TO. These 20 comparison targets span 9 categories, based on PortfoliosLab usage data.
Compare SURI with Any Fund or Stock
Compare SURI with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair SURI with funds that move differently
Simplify Propel Opportunities ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to SURI.
Explore SURI Diversifiers