Spero Therapeutics, Inc. (SPRO)

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The chart shows the growth of an initial investment of $10,000 in Spero Therapeutics, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.

Spero Therapeutics, Inc. (SPRO) has returned 0.43% so far this year and 225.00% over the past 12 months.

Based on dividend-adjusted daily data since Nov 2, 2017, SPRO's average daily return is +0.12%, while the average monthly return is +2.48%. At this rate, your investment would double in approximately 2.4 years.

Historically, 40% of months were positive and 60% were negative. The best month was May 2025 with a return of +279.9%, while the worst month was May 2022 at -75.7%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 9 months.

On a daily basis, SPRO closed higher 45% of trading days. The best single day was May 28, 2025 with a return of +244.6%, while the worst single day was May 3, 2022 at -63.7%.

Spero Therapeutics, Inc. has an annualized alpha of 22.88%, beta of 0.84, and R² of 0.02 versus S&P 500 Index. Calculated based on daily prices since November 03, 2017.

• This stock participated in 148.73% of S&P 500 Index downside but only 38.40% of its upside — more exposed to losses than it benefited from rallies.
• R² of 0.02 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

SPRO ranks 90 for risk / return — in the top 90% of stocks on our site. This means strong returns relative to risk — exactly what professional investors look for. Well-suited for investors who want to maximize return per unit of risk.

The table below present risk-adjusted performance metrics for Spero Therapeutics, Inc. (SPRO) and compare them to a chosen benchmark (S&P 500 Index).

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Spero Therapeutics, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Spero Therapeutics, Inc. was 97.46%, occurring on Apr 8, 2025. The portfolio has not yet recovered.

The current Spero Therapeutics, Inc. drawdown is 89.40%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Spero Therapeutics, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Spero Therapeutics, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.