SPRO vs. TQQQ
SPRO (Spero Therapeutics, Inc.) is a stock, while TQQQ (ProShares UltraPro QQQ) is Leveraged Equities fund tracking the NASDAQ-100 Index (300%). Over the past 5 years, SPRO returned -39.05%/yr vs 16.02%/yr for TQQQ. Their 0.26 correlation means their historical movements had little consistent relationship.
Performance
SPRO vs. TQQQ - Performance Comparison
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Returns By Period
In the year-to-date period, SPRO achieves a -50.64% return, which is significantly lower than TQQQ's 29.42% return.
SPRO
- 1D
- -1.71%
- 1M
- -47.73%
- 6M
- -48.43%
- YTD
- -50.64%
- 1Y
- -50.00%
- 3Y*
- -8.68%
- 5Y*
- -39.05%
- 10Y*
- —
- ALL TIME*
- -24.37%
TQQQ
- 1D
- 5.17%
- 1M
- -7.35%
- 6M
- 23.83%
- YTD
- 29.42%
- 1Y
- 64.98%
- 3Y*
- 50.64%
- 5Y*
- 16.02%
- 10Y*
- 39.51%
- ALL TIME*
- 42.74%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $3.18M | $3.27M | $3.19M | |
| $4.46B | $4.47B | $5.36B |
SPRO vs. TQQQ - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
SPRO Spero Therapeutics, Inc. | -50.64% | 126.21% | -29.93% | -15.03% | -89.19% | -17.43% | 101.66% | 56.34% | -47.66% | -11.32% |
TQQQ ProShares UltraPro QQQ | 29.42% | 34.35% | 58.27% | 198.04% | -79.09% | 82.98% | 110.05% | 133.84% | -19.79% | 6.89% |
Correlation
The correlation between SPRO and TQQQ is 0.24, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.24 |
Correlation (3Y) Balances recent behavior with more history. | 0.21 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.25 |
Correlation (All Time) Calculated using the full available price history since Nov 2, 2017 | 0.26 |
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Return for Risk
SPRO vs. TQQQ — Risk / Return Rank
SPRO
TQQQ
SPRO vs. TQQQ - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Spero Therapeutics, Inc. (SPRO) and ProShares UltraPro QQQ (TQQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SPRO | TQQQ | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.91 | ||
| Sortino ratioReturn per unit of downside risk | -2.60 | ||
| Omega ratioGain probability vs. loss probability | 0.87 | 1.21 | -0.34 |
| Calmar ratioReturn relative to maximum drawdown | -0.82 | 1.77 | -2.58 |
| Martin ratioReturn relative to average drawdown | -2.68 | 4.90 | -7.58 |
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Drawdowns
SPRO vs. TQQQ - Drawdown Comparison
The maximum SPRO drawdown since its inception was -97.46%, which is greater than TQQQ's maximum drawdown of -81.66%. Use the drawdown chart below to compare losses from any high point for SPRO and TQQQ.
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Drawdown Indicators
| SPRO | TQQQ | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.46% | -81.66% | -15.80% |
Max Drawdown (1Y)Largest decline over 1 year | -61.41% | -36.97% | -24.44% |
Max Drawdown (3Y)Largest decline over 3 years | -68.89% | -58.04% | -10.85% |
Max Drawdown (5Y)Largest decline over 5 years | -97.13% | -81.66% | -15.47% |
Max Drawdown (10Y)Largest decline over 10 years | — | -81.66% | — |
Current DrawdownCurrent decline from peak | -94.79% | -21.90% | -72.89% |
Average DrawdownAverage peak-to-trough decline | -62.81% | -18.50% | -44.31% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 18.67% | 13.31% | +5.36% |
Volatility
SPRO vs. TQQQ - Volatility Comparison
Spero Therapeutics, Inc. (SPRO) has a higher volatility of 28.60% compared to ProShares UltraPro QQQ (TQQQ) at 20.63%. This indicates that SPRO's price experiences larger fluctuations and is considered to be riskier than TQQQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SPRO | TQQQ | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 28.60% | 20.63% | +7.97% |
Volatility (6M)Calculated over the trailing 6-month period | 54.67% | 47.88% | +6.79% |
Volatility (1Y)Calculated over the trailing 1-year period | 64.65% | 57.57% | +7.08% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 152.44% | 68.10% | +84.34% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 124.55% | 66.61% | +57.94% |
Dividends
SPRO vs. TQQQ - Dividend Comparison
SPRO has not paid dividends to shareholders, while TQQQ's dividend yield for the trailing twelve months is around 0.56%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SPRO Spero Therapeutics, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
TQQQ ProShares UltraPro QQQ | 0.56% | 0.65% | 1.27% | 1.26% | 0.57% | 0.00% | 0.00% | 0.06% | 0.11% | 0.00% | 0.00% | 0.01% |
Frequently Asked Questions
SPRO and TQQQ have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SPRO has higher volatility (28.60%) compared to TQQQ (20.63%). In terms of maximum drawdown, SPRO dropped -97.46% vs TQQQ's -81.66%.
TQQQ currently has the higher Sharpe Ratio (1.14 vs -0.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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