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SPRO vs. TQQQ
Performance
Return for Risk
Drawdowns
Volatility
Dividends

SPRO vs. TQQQ

Last updated Jun 24, 2026

SPRO (Spero Therapeutics, Inc.) is a stock, while TQQQ (ProShares UltraPro QQQ) is Leveraged Equities fund tracking the NASDAQ-100 Index (300%). Over the past 5 years, SPRO returned -32.21%/yr vs 21.47%/yr for TQQQ. At a 0.26 correlation, their price movements are largely independent.

Performance

SPRO vs. TQQQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Spero Therapeutics, Inc. (SPRO) and ProShares UltraPro QQQ (TQQQ). The values are adjusted to include any dividend payments, if applicable.

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Returns By Period

In the year-to-date period, SPRO achieves a -7.73% return, which is significantly lower than TQQQ's 41.43% return.

SPRO

1D
-2.71%
1M
-22.10%
YTD
-7.73%
6M
-7.73%
1Y
-26.62%
3Y*
10.35%
5Y*
-32.21%
10Y*
—

TQQQ

1D
-9.86%
1M
-4.37%
YTD
41.43%
6M
35.75%
1Y
100.69%
3Y*
58.02%
5Y*
21.47%
10Y*
45.48%
*Multi-year figures are annualized to reflect compound growth (CAGR)

SPRO vs. TQQQ - Yearly Performance Comparison

2026 (YTD)202520242023202220212020201920182017
SPRO
Spero Therapeutics, Inc.		-7.73%126.21%-29.93%-15.03%-89.19%-17.43%101.66%56.34%-47.66%-11.32%
TQQQ
ProShares UltraPro QQQ		41.43%34.35%58.27%198.04%-79.09%82.98%110.05%133.84%-19.79%6.89%

Correlation

The correlation between SPRO and TQQQ is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

Correlation
Correlation (1Y)
Calculated over the trailing 1-year period

0.28

Correlation (3Y)
Calculated over the trailing 3-year period

0.24

Correlation (5Y)
Calculated over the trailing 5-year period

0.26

Correlation (All Time)
Calculated using the full available price history since Nov 2, 2017

0.26

Compare stocks, funds, or ETFs

Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.

Spero Therapeutics, Inc.

ProShares UltraPro QQQ

Often compared with SPRO:
SPRO vs. FOOD.TOSPRO vs. SPRXSPRO vs. BNTCSPRO vs. TLSASPRO vs. CRNCSPRO vs. DRUGSPRO vs. ARQT
Often compared with TQQQ:
TQQQ vs. QQQTQQQ vs. SOXLTQQQ vs. QLDTQQQ vs. SQQQTQQQ vs. UPROTQQQ vs. SPXLTQQQ vs. TECL

Return for Risk

SPRO vs. TQQQ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
SPRO
SPRO Risk / Return Rank: 2121
Overall Rank
SPRO Sharpe Ratio Rank: 2222
Sharpe Ratio Rank
SPRO Sortino Ratio Rank: 2525
Sortino Ratio Rank
SPRO Omega Ratio Rank: 2424
Omega Ratio Rank
SPRO Calmar Ratio Rank: 1717
Calmar Ratio Rank
SPRO Martin Ratio Rank: 1717
Martin Ratio Rank
TQQQ
TQQQ Risk / Return Rank: 5353
Overall Rank
TQQQ Sharpe Ratio Rank: 5858
Sharpe Ratio Rank
TQQQ Sortino Ratio Rank: 4747
Sortino Ratio Rank
TQQQ Omega Ratio Rank: 4949
Omega Ratio Rank
TQQQ Calmar Ratio Rank: 5757
Calmar Ratio Rank
TQQQ Martin Ratio Rank: 5252
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SPRO vs. TQQQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Spero Therapeutics, Inc. (SPRO) and ProShares UltraPro QQQ (TQQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

SPROTQQQDifference
Sharpe ratioReturn per unit of total volatility
-0.46
1.90

-2.36

Sortino ratioReturn per unit of downside risk
-0.29
2.27

-2.57

Omega ratioGain probability vs. loss probability

0.96

1.30

-0.34

Calmar ratioReturn relative to maximum drawdown

-0.67

2.74

-3.41

Martin ratioReturn relative to average drawdown

-1.15

8.72

-9.87

SPRO vs. TQQQ - Sharpe Ratio Comparison

The current SPRO Sharpe Ratio is -0.46, which is lower than the TQQQ Sharpe Ratio of 1.90. The chart below compares the historical Sharpe Ratios of SPRO and TQQQ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

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Drawdowns

SPRO vs. TQQQ - Drawdown Comparison

The maximum SPRO drawdown since its inception was -97.46%, which is greater than TQQQ's maximum drawdown of -81.66%. Use the drawdown chart below to compare losses from any high point for SPRO and TQQQ.

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Drawdown Indicators

SPROTQQQDifference

Max Drawdown

Largest peak-to-trough decline

-97.46%

-81.66%

-15.80%

Max Drawdown (1Y)

Largest decline over 1 year

-39.80%

-36.97%

-2.83%

Max Drawdown (3Y)

Largest decline over 3 years

-68.89%

-58.04%

-10.85%

Max Drawdown (5Y)

Largest decline over 5 years

-97.13%

-81.66%

-15.47%

Max Drawdown (10Y)

Largest decline over 10 years

—

-81.66%

—

Current Drawdown

Current decline from peak

-90.26%

-14.65%

-75.61%

Average Drawdown

Average peak-to-trough decline

-62.44%

-18.49%

-43.95%

Ulcer Index

Depth and duration of drawdowns from previous peaks

23.13%

11.59%

+11.54%

Volatility

SPRO vs. TQQQ - Volatility Comparison

Spero Therapeutics, Inc. (SPRO) has a higher volatility of 33.09% compared to ProShares UltraPro QQQ (TQQQ) at 27.27%. This indicates that SPRO's price experiences larger fluctuations and is considered to be riskier than TQQQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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Volatility by Period

SPROTQQQDifference

Volatility (1M)

Calculated over the trailing 1-month period

33.09%

27.27%

+5.82%

Volatility (6M)

Calculated over the trailing 6-month period

45.23%

43.35%

+1.88%

Volatility (1Y)

Calculated over the trailing 1-year period

58.61%

53.39%

+5.22%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

152.14%

67.41%

+84.73%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

124.88%

66.32%

+58.56%

Dividends

SPRO vs. TQQQ - Dividend Comparison

SPRO has not paid dividends to shareholders, while TQQQ's dividend yield for the trailing twelve months is around 0.42%.

PositionTTM20252024202320222021202020192018201720162015
SPRO
Spero Therapeutics, Inc.		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
TQQQ
ProShares UltraPro QQQ		0.42%0.65%1.27%1.26%0.57%0.00%0.00%0.06%0.11%0.00%0.00%0.01%

Frequently Asked Questions

SPRO and TQQQ have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

SPRO has higher volatility (33.09%) compared to TQQQ (27.27%). In terms of maximum drawdown, SPRO dropped -97.46% vs TQQQ's -81.66%.

TQQQ currently has the higher Sharpe Ratio (1.90 vs -0.46), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.

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