XHE vs. CANC

Last updated Jun 3, 2026

XHE (SPDR S&P Health Care Equipment ETF) and CANC (Tema Oncology ETF) are both Health & Biotech Equities funds. XHE is passively managed, while CANC is actively managed. Over the past 3 years, XHE returned -6.57%/yr vs 107.71%/yr for CANC. At a 0.43 correlation, their price movements are largely independent. XHE charges 0.35%/yr vs 0.75%/yr for CANC.

Performance

XHE vs. CANC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Health Care Equipment ETF (XHE) and Tema Oncology ETF (CANC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XHE achieves a -11.59% return, which is significantly lower than CANC's 4.74% return.

XHE

• 1D: -0.95%
• 1M: -4.49%
• YTD: -11.59%
• 6M: -10.52%
• 1Y: -2.63%
• 3Y*: -6.57%
• 5Y*: -8.01%
• 10Y*: 5.72%

CANC

• 1D: -2.40%
• 1M: -2.10%
• YTD: 4.74%
• 6M: 5.93%
• 1Y: 49.25%
• 3Y*: 107.71%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XHE vs. CANC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
XHE SPDR S&P Health Care Equipment ETF	-11.59%	-0.23%	5.08%	-6.23%	-23.34%	-6.25%
CANC Tema Oncology ETF	4.74%	42.92%	-5.37%	510.51%	-85.34%	-51.82%

Correlation

The correlation between XHE and CANC is 0.46, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.46
Correlation (3Y) Calculated over the trailing 3-year period	0.55
Correlation (All Time) Calculated using the full available price history since Oct 1, 2021	0.43

The correlation between XHE and CANC shifts across timeframes, from 0.43 (all time) to 0.55 (3 years), reflecting how their relationship changes across market environments.

XHE vs. CANC - Sectors Allocation Comparison

Sectors	XHE	CANC
Healthcare	98.4%	100.0%
Industrials	1.7%	-
Financial Services	1.6%	-
Communication Services	1.4%	-
Basic Materials	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

XHE vs. CANC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XHE

XHE Risk / Return Rank: 7
XHE Sharpe Ratio Rank: 7
XHE Sortino Ratio Rank: 7
XHE Omega Ratio Rank: 7
XHE Calmar Ratio Rank: 7
XHE Martin Ratio Rank: 6

CANC

CANC Risk / Return Rank: 70
CANC Sharpe Ratio Rank: 63
CANC Sortino Ratio Rank: 65
CANC Omega Ratio Rank: 55
CANC Calmar Ratio Rank: 90
CANC Martin Ratio Rank: 78

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XHE vs. CANC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Health Care Equipment ETF (XHE) and Tema Oncology ETF (CANC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XHE	CANC	Difference
Sharpe ratio Return per unit of total volatility	-0.12	2.14	-2.26
Sortino ratio Return per unit of downside risk	-0.03	3.05	-3.07
Omega ratio Gain probability vs. loss probability	1.00	1.35	-0.35
Calmar ratio Return relative to maximum drawdown	-0.21	5.75	-5.96
Martin ratio Return relative to average drawdown	-0.48	15.57	-16.05
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XHE vs. CANC - Sharpe Ratio Comparison

The current XHE Sharpe Ratio is -0.12, which is lower than the CANC Sharpe Ratio of 2.14. The chart below compares the historical Sharpe Ratios of XHE and CANC, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	XHE	CANC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.12	2.14	-2.26
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.33	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.25	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.40	-0.04	+0.44

Drawdowns

XHE vs. CANC - Drawdown Comparison

The maximum XHE drawdown since its inception was -49.92%, smaller than the maximum CANC drawdown of -97.53%. Use the drawdown chart below to compare losses from any high point for XHE and CANC.

Drawdown Indicators

	XHE	CANC	Difference
Max Drawdown Largest peak-to-trough decline	-49.92%	-97.53%	+47.61%
Max Drawdown (1Y) Largest decline over 1 year	-18.29%	-8.67%	-9.62%
Max Drawdown (3Y) Largest decline over 3 years	-32.62%	-30.27%	-2.35%
Max Drawdown (5Y) Largest decline over 5 years	-49.92%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-49.92%	—	—
Current Drawdown Current decline from peak	-41.39%	-56.58%	+15.19%
Average Drawdown Average peak-to-trough decline	-13.26%	-73.20%	+59.94%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.00%	3.20%	+4.80%

Volatility

XHE vs. CANC - Volatility Comparison

The current volatility for SPDR S&P Health Care Equipment ETF (XHE) is 5.82%, while Tema Oncology ETF (CANC) has a volatility of 6.55%. This indicates that XHE experiences smaller price fluctuations and is considered to be less risky than CANC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XHE	CANC	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.82%	6.55%	-0.73%
Volatility (6M) Calculated over the trailing 6-month period	15.38%	16.79%	-1.41%
Volatility (1Y) Calculated over the trailing 1-year period	21.39%	23.11%	-1.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.40%	280.39%	-255.99%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.93%	280.39%	-257.46%

XHE vs. CANC - Expense Ratio Comparison

XHE has a 0.35% expense ratio, which is lower than CANC's 0.75% expense ratio.

Dividends

XHE vs. CANC - Dividend Comparison

XHE's dividend yield for the trailing twelve months is around 0.09%, more than CANC's 0.05% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XHE SPDR S&P Health Care Equipment ETF	0.09%	0.08%	0.04%	0.03%	0.04%	0.00%	0.00%	0.05%	0.09%	0.78%	0.17%	7.22%

Frequently Asked Questions

Can I hold both XHE and CANC in my portfolio?

XHE and CANC have a correlation of 0.46, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XHE or CANC?

CANC has higher volatility (6.55%) compared to XHE (5.82%). In terms of maximum drawdown, XHE dropped -49.92% vs CANC's -97.53%.

Which ETF is better, XHE or CANC?

On 3-year performance, CANC leads with 107.71% vs -6.57% for XHE. On fees, XHE is cheaper at 0.35% per year. On volatility, XHE has been the lower-risk option at 5.82%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, XHE or CANC?

Over the 3-year period, CANC has performed better with a 107.71% return vs -6.57%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, XHE or CANC?

XHE is cheaper with a 0.35% expense ratio, compared with 0.75% for CANC.

Which ETF pays a higher dividend yield, XHE or CANC?

XHE has the higher dividend yield at 0.09%, compared with 0.05% for CANC.

What is the main difference between XHE and CANC?

They also come from different issuers: State Street and Tema. Their fees differ too: 0.35% for XHE and 0.75% for CANC.

Which has better risk-adjusted returns?

CANC currently has the higher Sharpe Ratio (2.14 vs -0.12), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.