XBI vs. IDNA

Last updated Jun 26, 2026

XBI (SPDR S&P Biotech ETF) and IDNA (iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund) are both Health & Biotech Equities funds - XBI tracks the S&P Biotechnology Select Industry Index while IDNA tracks the NYSE FactSet Global Genomics and Immuno Biopharma Index. Both are passively managed. Over the past 5 years, XBI returned 1.92%/yr vs -7.66%/yr for IDNA. Their correlation of 0.91 suggests significant overlap in exposure. XBI charges 0.35%/yr vs 0.47%/yr for IDNA.

Performance

XBI vs. IDNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both stocks are quite close, with XBI having a 24.45% return and IDNA slightly lower at 23.81%.

XBI

• 1D: 1.26%
• 1M: 13.79%
• YTD: 24.45%
• 6M: 20.14%
• 1Y: 82.88%
• 3Y*: 22.41%
• 5Y*: 1.92%
• 10Y*: 11.96%

IDNA

• 1D: 1.83%
• 1M: 9.00%
• YTD: 23.81%
• 6M: 20.37%
• 1Y: 57.96%
• 3Y*: 13.16%
• 5Y*: -7.66%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. IDNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
XBI SPDR S&P Biotech ETF	24.45%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	16.39%
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	23.81%	17.26%	-0.72%	-7.63%	-42.28%	-3.98%	54.30%	22.10%

Correlation

The correlation between XBI and IDNA is 0.90, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.90
Correlation (3Y) Calculated over the trailing 3-year period	0.90
Correlation (5Y) Calculated over the trailing 5-year period	0.90
Correlation (All Time) Calculated using the full available price history since Jun 13, 2019	0.91

The correlation between XBI and IDNA has been stable across timeframes, ranging from 0.90 to 0.91 - a consistent structural relationship.

XBI vs. IDNA - Sectors Allocation Comparison

Sectors	XBI	IDNA
Healthcare	99.7%	99.3%
Financial Services	0.3%	-
Basic Materials	0.2%	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	0.3%
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

XBI vs. IDNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 94
XBI Sharpe Ratio Rank: 95
XBI Sortino Ratio Rank: 93
XBI Omega Ratio Rank: 89
XBI Calmar Ratio Rank: 97
XBI Martin Ratio Rank: 95

IDNA

IDNA Risk / Return Rank: 83
IDNA Sharpe Ratio Rank: 84
IDNA Sortino Ratio Rank: 82
IDNA Omega Ratio Rank: 71
IDNA Calmar Ratio Rank: 92
IDNA Martin Ratio Rank: 85

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. IDNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XBI	IDNA	Difference
Sharpe ratio: Return per unit of total volatility	3.15	2.34	+0.81
Sortino ratio: Return per unit of downside risk	4.01	3.18	+0.82
Omega ratio: Gain probability vs. loss probability	1.48	1.36	+0.12
Calmar ratio: Return relative to maximum drawdown	8.57	5.46	+3.11
Martin ratio: Return relative to average drawdown	25.32	15.24	+10.08

XBI vs. IDNA - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 3.15, which is higher than the IDNA Sharpe Ratio of 2.34. The chart below compares the historical Sharpe Ratios of XBI and IDNA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XBI vs. IDNA - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, smaller than the maximum IDNA drawdown of -68.26%. Use the drawdown chart below to compare losses from any high point for XBI and IDNA.

Drawdown Indicators

	XBI	IDNA	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-68.26%	+4.37%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	-10.66%	+0.94%
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	-29.46%	-3.53%
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	-68.26%	+13.55%
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	—	—
Current Drawdown Current decline from peak	-12.30%	-38.95%	+26.65%
Average Drawdown Average peak-to-trough decline	-20.93%	-36.28%	+15.35%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.28%	3.81%	-0.53%

Volatility

XBI vs. IDNA - Volatility Comparison

SPDR S&P Biotech ETF (XBI) has a higher volatility of 9.94% compared to iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund (IDNA) at 7.56%. This indicates that XBI's price experiences larger fluctuations and is considered to be riskier than IDNA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	IDNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.94%	7.56%	+2.38%
Volatility (6M) Calculated over the trailing 6-month period	21.13%	18.41%	+2.72%
Volatility (1Y) Calculated over the trailing 1-year period	26.48%	24.97%	+1.51%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.30%	28.48%	+3.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.00%	29.51%	+2.49%

XBI vs. IDNA - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is lower than IDNA's 0.47% expense ratio.

Dividends

XBI vs. IDNA - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.38%, less than IDNA's 0.87% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
IDNA iShares Genomics Immunology and Healthcare ETF Genomics Immunology and Healthcare Fund	0.87%	1.18%	0.98%	1.04%	0.54%	0.70%	0.26%	0.80%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.38%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both XBI and IDNA in my portfolio?

With a correlation of 0.90, XBI and IDNA move almost identically. Holding both adds very little diversification - you're essentially doubling your position in the same market segment. Choosing one is usually more capital-efficient.

Which is riskier, XBI or IDNA?

XBI has higher volatility (9.94%) compared to IDNA (7.56%). In terms of maximum drawdown, XBI dropped -63.89% vs IDNA's -68.26%.

Which ETF is better, XBI or IDNA?

On 5-year performance, XBI leads with 1.92% vs -7.66% for IDNA. On fees, XBI is cheaper at 0.35% per year. On volatility, IDNA has been the lower-risk option at 7.56%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, XBI or IDNA?

Over the 5-year period, XBI has performed better with a 1.92% return vs -7.66%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, XBI or IDNA?

XBI is cheaper with a 0.35% expense ratio, compared with 0.47% for IDNA.

Which ETF pays a higher dividend yield, XBI or IDNA?

IDNA has the higher dividend yield at 0.87%, compared with 0.38% for XBI.

What is the main difference between XBI and IDNA?

XBI tracks S&P Biotechnology Select Industry Index, while IDNA tracks NYSE FactSet Global Genomics and Immuno Biopharma Index. They also come from different issuers: State Street and iShares. Their fees differ too: 0.35% for XBI and 0.47% for IDNA.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (3.15 vs 2.34), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.