VYGR vs. PBE

Last updated Jun 16, 2026

VYGR (Voyager Therapeutics, Inc.) is a stock, while PBE (Invesco Dynamic Biotechnology & Genome ETF) is Health & Biotech Equities fund tracking the Dynamic Biotech & Genome Intellidex Index (AMEX). Over the past 10 years, VYGR returned -12.79%/yr vs 8.90%/yr for PBE. At a 0.49 correlation, their price movements are largely independent.

Performance

VYGR vs. PBE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Voyager Therapeutics, Inc. (VYGR) and Invesco Dynamic Biotechnology & Genome ETF (PBE). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VYGR achieves a -7.63% return, which is significantly lower than PBE's 3.32% return. Over the past 10 years, VYGR has underperformed PBE with an annualized return of -12.79%, while PBE has yielded a comparatively higher 8.90% annualized return.

VYGR

• 1D: 3.71%
• 1M: -3.59%
• YTD: -7.63%
• 6M: -16.74%
• 1Y: 10.00%
• 3Y*: -34.59%
• 5Y*: -5.51%
• 10Y*: -12.79%

PBE

• 1D: 0.81%
• 1M: 4.85%
• YTD: 3.32%
• 6M: 5.17%
• 1Y: 34.13%
• 3Y*: 10.91%
• 5Y*: 2.31%
• 10Y*: 8.90%

*Multi-year figures are annualized to reflect compound growth (CAGR)

VYGR vs. PBE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
VYGR Voyager Therapeutics, Inc.	-7.63%	-30.69%	-32.82%	38.36%	125.09%	-62.10%	-48.75%	48.40%	-43.37%	30.30%
PBE Invesco Dynamic Biotechnology & Genome ETF	3.32%	24.84%	1.10%	3.71%	-10.83%	1.54%	25.66%	18.65%	-0.19%	22.28%

Correlation

The correlation between VYGR and PBE is 0.42, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.42
Correlation (3Y) Calculated over the trailing 3-year period	0.52
Correlation (5Y) Calculated over the trailing 5-year period	0.46
Correlation (10Y) Calculated over the trailing 10-year period	0.51
Correlation (All Time) Calculated using the full available price history since Nov 11, 2015	0.49

The correlation between VYGR and PBE has been stable across timeframes, ranging from 0.42 to 0.52 - a consistent structural relationship.

Return for Risk

VYGR vs. PBE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VYGR

VYGR Risk / Return Rank: 48
VYGR Sharpe Ratio Rank: 47
VYGR Sortino Ratio Rank: 48
VYGR Omega Ratio Rank: 46
VYGR Calmar Ratio Rank: 48
VYGR Martin Ratio Rank: 48

PBE

PBE Risk / Return Rank: 58
PBE Sharpe Ratio Rank: 58
PBE Sortino Ratio Rank: 63
PBE Omega Ratio Rank: 53
PBE Calmar Ratio Rank: 63
PBE Martin Ratio Rank: 52

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VYGR vs. PBE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Voyager Therapeutics, Inc. (VYGR) and Invesco Dynamic Biotechnology & Genome ETF (PBE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	VYGR	PBE	Difference
Sharpe ratio: Return per unit of total volatility	0.15	1.81	-1.65
Sortino ratio: Return per unit of downside risk	0.72	2.68	-1.97
Omega ratio: Gain probability vs. loss probability	1.08	1.31	-0.23
Calmar ratio: Return relative to maximum drawdown	0.27	2.92	-2.66
Martin ratio: Return relative to average drawdown	0.48	8.21	-7.73

VYGR vs. PBE - Sharpe Ratio Comparison

The current VYGR Sharpe Ratio is 0.15, which is lower than the PBE Sharpe Ratio of 1.81. The chart below compares the historical Sharpe Ratios of VYGR and PBE, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

VYGR vs. PBE - Drawdown Comparison

The maximum VYGR drawdown since its inception was -92.11%, which is greater than PBE's maximum drawdown of -45.69%. Use the drawdown chart below to compare losses from any high point for VYGR and PBE.

Drawdown Indicators

	VYGR	PBE	Difference
Max Drawdown Largest peak-to-trough decline	-92.11%	-45.69%	-46.42%
Max Drawdown (1Y) Largest decline over 1 year	-37.71%	-11.73%	-25.98%
Max Drawdown (3Y) Largest decline over 3 years	-80.49%	-22.43%	-58.06%
Max Drawdown (5Y) Largest decline over 5 years	-80.49%	-34.71%	-45.78%
Max Drawdown (10Y) Largest decline over 10 years	-92.11%	-37.84%	-54.27%
Current Drawdown Current decline from peak	-88.41%	-1.00%	-87.41%
Average Drawdown Average peak-to-trough decline	-66.91%	-16.21%	-50.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	21.10%	4.17%	+16.93%

Volatility

VYGR vs. PBE - Volatility Comparison

Voyager Therapeutics, Inc. (VYGR) has a higher volatility of 19.66% compared to Invesco Dynamic Biotechnology & Genome ETF (PBE) at 6.04%. This indicates that VYGR's price experiences larger fluctuations and is considered to be riskier than PBE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VYGR	PBE	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.66%	6.04%	+13.62%
Volatility (6M) Calculated over the trailing 6-month period	43.72%	13.67%	+30.05%
Volatility (1Y) Calculated over the trailing 1-year period	65.19%	19.01%	+46.18%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	80.85%	22.48%	+58.37%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	75.87%	24.91%	+50.96%

Dividends

VYGR vs. PBE - Dividend Comparison

VYGR has not paid dividends to shareholders, while PBE's dividend yield for the trailing twelve months is around 1.02%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PBE Invesco Dynamic Biotechnology & Genome ETF	1.02%	1.00%	0.05%	0.02%	0.00%	0.00%	0.04%	0.00%	0.00%	0.57%	0.38%	1.12%
VYGR Voyager Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both VYGR and PBE in my portfolio?

VYGR and PBE have a correlation of 0.42, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VYGR or PBE?

VYGR has higher volatility (19.66%) compared to PBE (6.04%). In terms of maximum drawdown, VYGR dropped -92.11% vs PBE's -45.69%.

Which has better risk-adjusted returns?

PBE currently has the higher Sharpe Ratio (1.81 vs 0.15), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.