VXRT vs. AMLX

Last updated Aug 1, 2026

VXRT (Vaxart, Inc.) and AMLX (Amylyx Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, VXRT returned -11.52%/yr vs -4.58%/yr for AMLX. Their 0.22 correlation means their historical movements had little consistent relationship.

Performance

VXRT vs. AMLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vaxart, Inc. (VXRT) and Amylyx Pharmaceuticals, Inc. (AMLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VXRT achieves a 55.89% return, which is significantly lower than AMLX's 68.13% return.

VXRT

• 1D: 2.46%
• 1M: -15.63%
• 6M: -6.86%
• YTD: 55.89%
• 1Y: 51.77%
• 3Y*: -11.52%
• 5Y*: -40.42%
• 10Y*: —
• ALL TIME*: -27.88%

AMLX

• 1D: -2.12%
• 1M: 11.17%
• 6M: 42.13%
• YTD: 68.13%
• 1Y: 163.25%
• 3Y*: -4.58%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -0.73%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
AMLX Amylyx Pharmaceuticals, Inc.	$41.59M	$31.68M	$25.94M
VXRT Vaxart, Inc.	$154.47K	$165.76K	$219.97K

VXRT vs. AMLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
VXRT Vaxart, Inc.	55.89%	-47.68%	15.59%	-40.39%	-84.48%
AMLX Amylyx Pharmaceuticals, Inc.	68.13%	219.58%	-74.32%	-60.16%	75.95%

Correlation

The correlation between VXRT and AMLX is 0.12, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.12
Correlation (3Y) Balances recent behavior with more history.	0.19
Correlation (All Time) Calculated using the full available price history since Jan 7, 2022	0.22

Fundamentals

Market Cap VXRT : $130.70M AMLX : $2.26B
EPS VXRT : $0.16 AMLX : -$1.51
PB Ratio VXRT : 1.39 AMLX : 8.22
Total Revenue (TTM) VXRT : $255.61M AMLX : $0.00
Gross Profit (TTM) VXRT : $193.63M AMLX : -$20.10M
EBITDA (TTM) VXRT : $45.63M AMLX : -$150.30M

Return for Risk

VXRT vs. AMLX — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

VXRT

VXRT Risk / Return Rank: 67
VXRT Sharpe Ratio Rank: 63
VXRT Sortino Ratio Rank: 69
VXRT Omega Ratio Rank: 70
VXRT Calmar Ratio Rank: 67
VXRT Martin Ratio Rank: 68

AMLX

AMLX Risk / Return Rank: 93
AMLX Sharpe Ratio Rank: 96
AMLX Sortino Ratio Rank: 93
AMLX Omega Ratio Rank: 89
AMLX Calmar Ratio Rank: 95
AMLX Martin Ratio Rank: 92

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

VXRT vs. AMLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vaxart, Inc. (VXRT) and Amylyx Pharmaceuticals, Inc. (AMLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	VXRT	AMLX	Difference
Sharpe ratio: Return per unit of total volatility	0.53	2.51	-1.99
Sortino ratio: Return per unit of downside risk	1.46	3.07	-1.61
Omega ratio: Gain probability vs. loss probability	1.19	1.35	-0.16
Calmar ratio: Return relative to maximum drawdown	1.06	5.03	-3.97
Martin ratio: Return relative to average drawdown	2.52	10.76	-8.24

VXRT vs. AMLX - Sharpe Ratio Comparison

The current VXRT Sharpe Ratio is 0.53, which is lower than the AMLX Sharpe Ratio of 2.51. The chart below compares the historical Sharpe Ratios of VXRT and AMLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

VXRT vs. AMLX - Drawdown Comparison

The maximum VXRT drawdown since its inception was -98.71%, roughly equal to the maximum AMLX drawdown of -96.04%. Use the drawdown chart below to compare losses from any high point for VXRT and AMLX.

Drawdown Indicators

	VXRT	AMLX	Difference
Max Drawdown Largest peak-to-trough decline	-98.71%	-96.04%	-2.67%
Max Drawdown (1Y) Largest decline over 1 year	-43.74%	-30.61%	-13.13%
Max Drawdown (3Y) Largest decline over 3 years	-78.72%	-92.82%	+14.10%
Max Drawdown (5Y) Largest decline over 5 years	-96.94%	—	—
Current Drawdown Current decline from peak	-97.69%	-50.38%	-47.31%
Average Drawdown Average peak-to-trough decline	-83.17%	-59.30%	-23.87%
Ulcer Index Depth and duration of drawdowns from previous peaks	18.26%	14.27%	+3.99%

Volatility

VXRT vs. AMLX - Volatility Comparison

Vaxart, Inc. (VXRT) has a higher volatility of 22.10% compared to Amylyx Pharmaceuticals, Inc. (AMLX) at 15.49%. This indicates that VXRT's price experiences larger fluctuations and is considered to be riskier than AMLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VXRT	AMLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.10%	15.49%	+6.61%
Volatility (6M) Calculated over the trailing 6-month period	50.47%	39.64%	+10.83%
Volatility (1Y) Calculated over the trailing 1-year period	87.77%	61.22%	+26.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	92.48%	90.71%	+1.77%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	127.94%	90.71%	+37.23%

Dividends

VXRT vs. AMLX - Dividend Comparison

Neither VXRT nor AMLX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both VXRT and AMLX in my portfolio?

VXRT and AMLX have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VXRT or AMLX?

VXRT has higher volatility (22.10%) compared to AMLX (15.49%). In terms of maximum drawdown, VXRT dropped -98.71% vs AMLX's -96.04%.

Which has better risk-adjusted returns?

AMLX currently has the higher Sharpe Ratio (2.51 vs 0.53), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.