AMLX vs. DCTH

Last updated Apr 1, 2026

Compare and contrast key facts about Amylyx Pharmaceuticals, Inc. (AMLX) and Delcath Systems, Inc. (DCTH).

Performance

AMLX vs. DCTH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amylyx Pharmaceuticals, Inc. (AMLX) and Delcath Systems, Inc. (DCTH). The values are adjusted to include any dividend payments, if applicable.

AMLX vs. DCTH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
AMLX Amylyx Pharmaceuticals, Inc.	15.07%	219.58%	-74.32%	-60.16%	104.48%
DCTH Delcath Systems, Inc.	-8.12%	-16.11%	189.42%	15.56%	-50.89%

Fundamentals

Market Cap AMLX : $1.31B DCTH : $338.22M
EPS AMLX : -$1.57 DCTH : $0.07
PB Ratio AMLX : 4.31 DCTH : 3.04
Total Revenue (TTM) AMLX : $0.00 DCTH : $64.50M
Gross Profit (TTM) AMLX : $0.00 DCTH : $73.43M
EBITDA (TTM) AMLX : -$144.16M DCTH : $1.61M

Returns By Period

In the year-to-date period, AMLX achieves a 15.07% return, which is significantly higher than DCTH's -8.12% return.

AMLX

• 1D: 8.93%
• 1M: -8.37%
• YTD: 15.07%
• 6M: 2.28%
• 1Y: 292.66%
• 3Y*: -22.04%
• 5Y*: —
• 10Y*: —

DCTH

• 1D: 4.39%
• 1M: 4.27%
• YTD: -8.12%
• 6M: -13.67%
• 1Y: -27.10%
• 3Y*: 17.30%
• 5Y*: -5.40%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

AMLX vs. DCTH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AMLX

AMLX Risk / Return Rank: 97
AMLX Sharpe Ratio Rank: 99
AMLX Sortino Ratio Rank: 97
AMLX Omega Ratio Rank: 94
AMLX Calmar Ratio Rank: 98
AMLX Martin Ratio Rank: 98

DCTH

DCTH Risk / Return Rank: 24
DCTH Sharpe Ratio Rank: 21
DCTH Sortino Ratio Rank: 21
DCTH Omega Ratio Rank: 23
DCTH Calmar Ratio Rank: 24
DCTH Martin Ratio Rank: 29

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AMLX vs. DCTH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amylyx Pharmaceuticals, Inc. (AMLX) and Delcath Systems, Inc. (DCTH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AMLX	DCTH	Difference
Sharpe ratio Return per unit of total volatility	4.03	-0.47	+4.50
Sortino ratio Return per unit of downside risk	4.16	-0.39	+4.55
Omega ratio Gain probability vs. loss probability	1.49	0.95	+0.53
Calmar ratio Return relative to maximum drawdown	10.02	-0.54	+10.56
Martin ratio Return relative to average drawdown	23.29	-0.77	+24.06
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AMLX vs. DCTH - Sharpe Ratio Comparison

The current AMLX Sharpe Ratio is 4.03, which is higher than the DCTH Sharpe Ratio of -0.47. The chart below compares the historical Sharpe Ratios of AMLX and DCTH, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	AMLX	DCTH	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.03	-0.47	+4.50
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.07	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.07	-0.45	+0.38

Correlation

The correlation between AMLX and DCTH is 0.17, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

AMLX vs. DCTH - Dividend Comparison

Neither AMLX nor DCTH has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

AMLX vs. DCTH - Drawdown Comparison

The maximum AMLX drawdown since its inception was -96.04%, roughly equal to the maximum DCTH drawdown of -99.96%. Use the drawdown chart below to compare losses from any high point for AMLX and DCTH.

Drawdown Indicators

	AMLX	DCTH	Difference
Max Drawdown Largest peak-to-trough decline	-96.04%	-99.96%	+3.92%
Max Drawdown (1Y) Largest decline over 1 year	-27.93%	-54.75%	+26.82%
Max Drawdown (5Y) Largest decline over 5 years	—	-85.10%	—
Current Drawdown Current decline from peak	-66.04%	-99.85%	+33.81%
Average Drawdown Average peak-to-trough decline	-59.24%	-96.38%	+37.14%
Ulcer Index Depth and duration of drawdowns from previous peaks	12.01%	38.26%	-26.25%

Volatility

AMLX vs. DCTH - Volatility Comparison

Amylyx Pharmaceuticals, Inc. (AMLX) has a higher volatility of 19.23% compared to Delcath Systems, Inc. (DCTH) at 12.83%. This indicates that AMLX's price experiences larger fluctuations and is considered to be riskier than DCTH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AMLX	DCTH	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.23%	12.83%	+6.40%
Volatility (6M) Calculated over the trailing 6-month period	45.20%	36.46%	+8.74%
Volatility (1Y) Calculated over the trailing 1-year period	73.18%	58.48%	+14.70%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	92.82%	74.15%	+18.67%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	92.82%	111.20%	-18.38%

Financials