AMLX vs. DCTH

Last updated Jun 23, 2026

AMLX (Amylyx Pharmaceuticals, Inc.) and DCTH (Delcath Systems, Inc.) are both stocks. Both are in the Healthcare sector — AMLX in Biotechnology, DCTH in Medical Devices. Over the past 3 years, AMLX returned -10.96%/yr vs 27.37%/yr for DCTH. At a 0.18 correlation, their price movements are largely independent.

Performance

AMLX vs. DCTH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amylyx Pharmaceuticals, Inc. (AMLX) and Delcath Systems, Inc. (DCTH). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AMLX achieves a 34.77% return, which is significantly higher than DCTH's 13.96% return.

AMLX

• 1D: 3.89%
• 1M: 19.88%
• YTD: 34.77%
• 6M: 30.24%
• 1Y: 222.38%
• 3Y*: -10.96%
• 5Y*: —
• 10Y*: —

DCTH

• 1D: -1.54%
• 1M: 4.45%
• YTD: 13.96%
• 6M: 14.30%
• 1Y: -16.90%
• 3Y*: 27.37%
• 5Y*: 1.93%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

AMLX vs. DCTH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
AMLX Amylyx Pharmaceuticals, Inc.	34.77%	219.58%	-74.32%	-60.16%	75.95%
DCTH Delcath Systems, Inc.	13.96%	-16.11%	189.42%	15.56%	-51.09%

Correlation

The correlation between AMLX and DCTH is 0.36, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.36
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (All Time) Calculated using the full available price history since Jan 7, 2022	0.18

The correlation between AMLX and DCTH shifts across timeframes, from 0.18 (all time) to 0.36 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap AMLX : $1.80B DCTH : $414.60M
EPS AMLX : -$1.55 DCTH : $0.01
PB Ratio AMLX : 6.59 DCTH : 3.68
Total Revenue (TTM) AMLX : $0.00 DCTH : $65.45M
Gross Profit (TTM) AMLX : -$20.10M DCTH : $77.75M
EBITDA (TTM) AMLX : -$150.30M DCTH : $222.00K

Return for Risk

AMLX vs. DCTH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AMLX

AMLX Risk / Return Rank: 94
AMLX Sharpe Ratio Rank: 96
AMLX Sortino Ratio Rank: 95
AMLX Omega Ratio Rank: 91
AMLX Calmar Ratio Rank: 96
AMLX Martin Ratio Rank: 94

DCTH

DCTH Risk / Return Rank: 28
DCTH Sharpe Ratio Rank: 27
DCTH Sortino Ratio Rank: 27
DCTH Omega Ratio Rank: 27
DCTH Calmar Ratio Rank: 28
DCTH Martin Ratio Rank: 30

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AMLX vs. DCTH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amylyx Pharmaceuticals, Inc. (AMLX) and Delcath Systems, Inc. (DCTH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	AMLX	DCTH	Difference
Sharpe ratio: Return per unit of total volatility	3.33	-0.34	+3.67
Sortino ratio: Return per unit of downside risk	3.85	-0.18	+4.03
Omega ratio: Gain probability vs. loss probability	1.44	0.98	+0.46
Calmar ratio: Return relative to maximum drawdown	7.31	-0.41	+7.72
Martin ratio: Return relative to average drawdown	15.68	-0.64	+16.32

AMLX vs. DCTH - Sharpe Ratio Comparison

The current AMLX Sharpe Ratio is 3.33, which is higher than the DCTH Sharpe Ratio of -0.34. The chart below compares the historical Sharpe Ratios of AMLX and DCTH, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

AMLX vs. DCTH - Drawdown Comparison

The maximum AMLX drawdown since its inception was -96.04%, roughly equal to the maximum DCTH drawdown of -99.96%. Use the drawdown chart below to compare losses from any high point for AMLX and DCTH.

Drawdown Indicators

	AMLX	DCTH	Difference
Max Drawdown Largest peak-to-trough decline	-96.04%	-99.96%	+3.92%
Max Drawdown (1Y) Largest decline over 1 year	-30.61%	-41.71%	+11.10%
Max Drawdown (3Y) Largest decline over 3 years	-93.09%	-62.87%	-30.22%
Max Drawdown (5Y) Largest decline over 5 years	—	-82.21%	—
Current Drawdown Current decline from peak	-60.22%	-99.81%	+39.59%
Average Drawdown Average peak-to-trough decline	-59.40%	-96.43%	+37.03%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.25%	26.33%	-12.08%

Volatility

AMLX vs. DCTH - Volatility Comparison

Amylyx Pharmaceuticals, Inc. (AMLX) has a higher volatility of 16.44% compared to Delcath Systems, Inc. (DCTH) at 13.30%. This indicates that AMLX's price experiences larger fluctuations and is considered to be riskier than DCTH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AMLX	DCTH	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.44%	13.30%	+3.14%
Volatility (6M) Calculated over the trailing 6-month period	43.21%	32.57%	+10.64%
Volatility (1Y) Calculated over the trailing 1-year period	67.39%	49.63%	+17.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	91.47%	73.00%	+18.47%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	91.47%	109.86%	-18.39%

Dividends

AMLX vs. DCTH - Dividend Comparison

Neither AMLX nor DCTH has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AMLX and DCTH in my portfolio?

AMLX and DCTH have a correlation of 0.36, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AMLX or DCTH?

AMLX has higher volatility (16.44%) compared to DCTH (13.30%). In terms of maximum drawdown, AMLX dropped -96.04% vs DCTH's -99.96%.

Which has better risk-adjusted returns?

AMLX currently has the higher Sharpe Ratio (3.33 vs -0.34), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.