VXRT vs. CYCN

Last updated Jun 5, 2026

VXRT (Vaxart, Inc.) and CYCN (Cyclerion Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, VXRT returned -38.25%/yr vs -45.53%/yr for CYCN. At a 0.08 correlation, their price movements are largely independent.

Performance

VXRT vs. CYCN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Vaxart, Inc. (VXRT) and Cyclerion Therapeutics, Inc. (CYCN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, VXRT achieves a 78.05% return, which is significantly lower than CYCN's 140.94% return.

VXRT

• 1D: 2.78%
• 1M: -18.31%
• YTD: 78.05%
• 6M: 66.70%
• 1Y: 52.67%
• 3Y*: -21.40%
• 5Y*: -38.25%
• 10Y*: —

CYCN

• 1D: 2.00%
• 1M: -2.86%
• YTD: 140.94%
• 6M: 80.00%
• 1Y: -2.24%
• 3Y*: -10.93%
• 5Y*: -45.53%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

VXRT vs. CYCN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
VXRT Vaxart, Inc.	78.05%	-47.68%	15.59%	-40.39%	-84.67%	9.81%	1,529.10%	-82.39%
CYCN Cyclerion Therapeutics, Inc.	140.94%	-60.56%	-3.88%	-74.47%	-61.85%	-43.79%	12.50%	-81.23%

Correlation

The correlation between VXRT and CYCN is 0.10, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.10
Correlation (3Y) Calculated over the trailing 3-year period	0.03
Correlation (5Y) Calculated over the trailing 5-year period	0.10
Correlation (All Time) Calculated using the full available price history since Apr 3, 2019	0.08

Fundamentals

Market Cap VXRT : $149.37M CYCN : $12.87M
EPS VXRT : $0.16 CYCN : -$0.61
PS Ratio VXRT : 0.56 CYCN : 5.27
PB Ratio VXRT : 1.59 CYCN : 1.89
Total Revenue (TTM) VXRT : $255.61M CYCN : $1.99M
Gross Profit (TTM) VXRT : $193.63M CYCN : $1.99M
EBITDA (TTM) VXRT : $45.63M CYCN : -$6.70M

Return for Risk

VXRT vs. CYCN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VXRT

VXRT Risk / Return Rank: 62
VXRT Sharpe Ratio Rank: 58
VXRT Sortino Ratio Rank: 68
VXRT Omega Ratio Rank: 69
VXRT Calmar Ratio Rank: 61
VXRT Martin Ratio Rank: 56

CYCN

CYCN Risk / Return Rank: 59
CYCN Sharpe Ratio Rank: 41
CYCN Sortino Ratio Rank: 89
CYCN Omega Ratio Rank: 87
CYCN Calmar Ratio Rank: 40
CYCN Martin Ratio Rank: 40

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

VXRT vs. CYCN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Vaxart, Inc. (VXRT) and Cyclerion Therapeutics, Inc. (CYCN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	VXRT	CYCN	Difference
Sharpe ratio: Return per unit of total volatility	0.50	-0.01	+0.50
Sortino ratio: Return per unit of downside risk	1.60	3.09	-1.49
Omega ratio: Gain probability vs. loss probability	1.22	1.39	-0.18
Calmar ratio: Return relative to maximum drawdown	0.92	-0.03	+0.96
Martin ratio: Return relative to average drawdown	1.45	-0.05	+1.50
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

VXRT vs. CYCN - Sharpe Ratio Comparison

The current VXRT Sharpe Ratio is 0.50, which is higher than the CYCN Sharpe Ratio of -0.01. The chart below compares the historical Sharpe Ratios of VXRT and CYCN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	VXRT	CYCN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.50	-0.01	+0.50
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.41	-0.20	-0.21
Sharpe Ratio (All Time) Calculated using the full available price history	-0.21	-0.23	+0.02

Drawdowns

VXRT vs. CYCN - Drawdown Comparison

The maximum VXRT drawdown since its inception was -98.71%, roughly equal to the maximum CYCN drawdown of -99.71%. Use the drawdown chart below to compare losses from any high point for VXRT and CYCN.

Drawdown Indicators

	VXRT	CYCN	Difference
Max Drawdown Largest peak-to-trough decline	-98.71%	-99.71%	+1.00%
Max Drawdown (1Y) Largest decline over 1 year	-57.26%	-70.33%	+13.07%
Max Drawdown (3Y) Largest decline over 3 years	-78.72%	-82.99%	+4.27%
Max Drawdown (5Y) Largest decline over 5 years	-96.94%	-98.74%	+1.80%
Current Drawdown Current decline from peak	-97.36%	-99.17%	+1.81%
Average Drawdown Average peak-to-trough decline	-82.94%	-87.74%	+4.80%
Ulcer Index Depth and duration of drawdowns from previous peaks	36.31%	47.22%	-10.91%

Volatility

VXRT vs. CYCN - Volatility Comparison

Vaxart, Inc. (VXRT) has a higher volatility of 20.57% compared to Cyclerion Therapeutics, Inc. (CYCN) at 8.83%. This indicates that VXRT's price experiences larger fluctuations and is considered to be riskier than CYCN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	VXRT	CYCN	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.57%	8.83%	+11.74%
Volatility (6M) Calculated over the trailing 6-month period	76.62%	161.83%	-85.21%
Volatility (1Y) Calculated over the trailing 1-year period	106.88%	328.07%	-221.19%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	93.04%	230.17%	-137.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	128.84%	204.14%	-75.30%

Dividends

VXRT vs. CYCN - Dividend Comparison

Neither VXRT nor CYCN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both VXRT and CYCN in my portfolio?

VXRT and CYCN have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, VXRT or CYCN?

VXRT has higher volatility (20.57%) compared to CYCN (8.83%). In terms of maximum drawdown, VXRT dropped -98.71% vs CYCN's -99.71%.

Which has better risk-adjusted returns?

VXRT currently has the higher Sharpe Ratio (0.50 vs -0.01), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.