TNYA vs. DFTX
TNYA (Tenaya Therapeutics, Inc.) and DFTX (Definium Therapeutics, Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, TNYA returned -45.80%/yr vs 107.23%/yr for DFTX. Their 0.28 correlation means their historical movements had little consistent relationship.
Performance
TNYA vs. DFTX - Performance Comparison
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Returns By Period
In the year-to-date period, TNYA achieves a 4.05% return, which is significantly lower than DFTX's 225.02% return.
TNYA
- 1D
- -1.29%
- 1M
- -5.92%
- 6M
- -4.44%
- YTD
- 4.05%
- 1Y
- 10.39%
- 3Y*
- -45.80%
- 5Y*
- -45.47%
- 10Y*
- —
- ALL TIME*
- -48.00%
DFTX
- 1D
- -2.18%
- 1M
- -1.52%
- 6M
- 157.82%
- YTD
- 225.02%
- 1Y
- 415.64%
- 3Y*
- 107.23%
- 5Y*
- —
- 10Y*
- —
- ALL TIME*
- 42.51%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $64.44M | $84.24M | $99.34M | |
| $1.19M | $2.08M | $2.83M |
TNYA vs. DFTX - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|---|
TNYA Tenaya Therapeutics, Inc. | 4.05% | -50.24% | -55.86% | 61.19% | -64.61% |
DFTX Definium Therapeutics, Inc | 225.02% | 92.39% | 90.16% | 66.36% | -78.74% |
Correlation
The correlation between TNYA and DFTX is 0.10, meaning there was essentially no consistent relationship between their historical price movements. Each responded to its own set of market drivers.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.10 |
Correlation (3Y) Balances recent behavior with more history. | 0.29 |
Correlation (All Time) Calculated using the full available price history since Jul 11, 2022 | 0.28 |
The correlation between TNYA and DFTX shifts across timeframes, from 0.10 (1 year) to 0.29 (3 years), reflecting how their relationship changes across market environments.
Fundamentals
TNYA:
$160.64M
DFTX:
$4.75B
TNYA:
-$0.47
DFTX:
-$2.51
TNYA:
1.51
DFTX:
16.98
TNYA:
$225.00K
DFTX:
$0.00
TNYA:
$0.00
DFTX:
$0.00
TNYA:
-$78.62M
DFTX:
-$206.36M
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Return for Risk
TNYA vs. DFTX — Risk / Return Rank
TNYA
DFTX
TNYA vs. DFTX - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Tenaya Therapeutics, Inc. (TNYA) and Definium Therapeutics, Inc (DFTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| TNYA | DFTX | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -4.70 | ||
| Sortino ratioReturn per unit of downside risk | -4.13 | ||
| Omega ratioGain probability vs. loss probability | 1.12 | 1.60 | -0.48 |
| Calmar ratioReturn relative to maximum drawdown | 0.13 | 15.40 | -15.27 |
| Martin ratioReturn relative to average drawdown | 0.18 | 47.19 | -47.01 |
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Drawdowns
TNYA vs. DFTX - Drawdown Comparison
The maximum TNYA drawdown since its inception was -98.69%, which is greater than DFTX's maximum drawdown of -86.01%. Use the drawdown chart below to compare losses from any high point for TNYA and DFTX.
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Drawdown Indicators
| TNYA | DFTX | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -98.69% | -86.01% | -12.68% |
Max Drawdown (1Y)Largest decline over 1 year | -73.81% | -24.79% | -49.02% |
Max Drawdown (3Y)Largest decline over 3 years | -94.30% | -58.38% | -35.92% |
Max Drawdown (5Y)Largest decline over 5 years | -98.69% | — | — |
Current DrawdownCurrent decline from peak | -97.50% | -10.18% | -87.32% |
Average DrawdownAverage peak-to-trough decline | -82.55% | -49.74% | -32.81% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 52.56% | 8.09% | +44.47% |
Volatility
TNYA vs. DFTX - Volatility Comparison
Tenaya Therapeutics, Inc. (TNYA) has a higher volatility of 17.00% compared to Definium Therapeutics, Inc (DFTX) at 16.10%. This indicates that TNYA's price experiences larger fluctuations and is considered to be riskier than DFTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| TNYA | DFTX | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 17.00% | 16.10% | +0.90% |
Volatility (6M)Calculated over the trailing 6-month period | 67.10% | 56.99% | +10.11% |
Volatility (1Y)Calculated over the trailing 1-year period | 107.03% | 79.66% | +27.37% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 107.78% | 87.09% | +20.69% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 108.16% | 87.09% | +21.07% |
Dividends
TNYA vs. DFTX - Dividend Comparison
Neither TNYA nor DFTX has paid dividends to shareholders.
Financials
TNYA vs. DFTX - Financials Comparison
This section allows you to compare key financial metrics between Tenaya Therapeutics, Inc. and Definium Therapeutics, Inc. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
TNYA and DFTX have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
TNYA has higher volatility (17.00%) compared to DFTX (16.10%). In terms of maximum drawdown, TNYA dropped -98.69% vs DFTX's -86.01%.
DFTX currently has the higher Sharpe Ratio (4.79 vs 0.09), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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