SUPN vs. DFTX

Last updated Jun 4, 2026

SUPN (Supernus Pharmaceuticals, Inc.) and DFTX (Definium Therapeutics, Inc) are both stocks. Both are in the Healthcare sector — SUPN in Drug Manufacturers - Specialty & Generic, DFTX in Biotechnology. Over the past 3 years, SUPN returned 9.51%/yr vs 89.71%/yr for DFTX. At a 0.22 correlation, their price movements are largely independent.

Performance

SUPN vs. DFTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Supernus Pharmaceuticals, Inc. (SUPN) and Definium Therapeutics, Inc (DFTX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SUPN achieves a -11.40% return, which is significantly lower than DFTX's 76.18% return.

SUPN

• 1D: -0.08%
• 1M: -9.45%
• YTD: -11.40%
• 6M: -1.62%
• 1Y: 36.63%
• 3Y*: 9.51%
• 5Y*: 8.06%
• 10Y*: 8.47%

DFTX

• 1D: 3.19%
• 1M: 8.46%
• YTD: 76.18%
• 6M: 97.57%
• 1Y: 206.76%
• 3Y*: 89.71%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

SUPN vs. DFTX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
SUPN Supernus Pharmaceuticals, Inc.	-11.40%	37.44%	24.95%	-18.87%	20.43%
DFTX Definium Therapeutics, Inc	76.18%	92.39%	90.16%	66.36%	-76.86%

Correlation

The correlation between SUPN and DFTX is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.25
Correlation (3Y) Calculated over the trailing 3-year period	0.22
Correlation (All Time) Calculated using the full available price history since Jul 12, 2022	0.22

Fundamentals

Market Cap SUPN : $2.54B DFTX : $2.57B
EPS SUPN : -$0.51 DFTX : -$2.57
PB Ratio SUPN : 2.36 DFTX : 9.20
Total Revenue (TTM) SUPN : $776.83M DFTX : $0.00
Gross Profit (TTM) SUPN : $665.28M DFTX : $0.00
EBITDA (TTM) SUPN : $78.83M DFTX : -$206.36M

Return for Risk

SUPN vs. DFTX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SUPN

SUPN Risk / Return Rank: 69
SUPN Sharpe Ratio Rank: 73
SUPN Sortino Ratio Rank: 66
SUPN Omega Ratio Rank: 70
SUPN Calmar Ratio Rank: 71
SUPN Martin Ratio Rank: 68

DFTX

DFTX Risk / Return Rank: 94
DFTX Sharpe Ratio Rank: 96
DFTX Sortino Ratio Rank: 93
DFTX Omega Ratio Rank: 89
DFTX Calmar Ratio Rank: 96
DFTX Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SUPN vs. DFTX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Supernus Pharmaceuticals, Inc. (SUPN) and Definium Therapeutics, Inc (DFTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SUPN	DFTX	Difference
Sharpe ratio: Return per unit of total volatility	1.02	3.37	-2.35
Sortino ratio: Return per unit of downside risk	1.51	3.62	-2.11
Omega ratio: Gain probability vs. loss probability	1.22	1.42	-0.20
Calmar ratio: Return relative to maximum drawdown	1.62	8.40	-6.78
Martin ratio: Return relative to average drawdown	3.39	24.79	-21.40
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SUPN vs. DFTX - Sharpe Ratio Comparison

The current SUPN Sharpe Ratio is 1.02, which is lower than the DFTX Sharpe Ratio of 3.37. The chart below compares the historical Sharpe Ratios of SUPN and DFTX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	SUPN	DFTX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.02	3.37	-2.35
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.23	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.19	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.28	0.31	-0.04

Drawdowns

SUPN vs. DFTX - Drawdown Comparison

The maximum SUPN drawdown since its inception was -75.86%, smaller than the maximum DFTX drawdown of -86.01%. Use the drawdown chart below to compare losses from any high point for SUPN and DFTX.

Drawdown Indicators

	SUPN	DFTX	Difference
Max Drawdown Largest peak-to-trough decline	-75.86%	-86.01%	+10.15%
Max Drawdown (1Y) Largest decline over 1 year	-22.75%	-24.79%	+2.04%
Max Drawdown (3Y) Largest decline over 3 years	-36.16%	-58.38%	+22.22%
Max Drawdown (5Y) Largest decline over 5 years	-45.94%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-75.86%	—	—
Current Drawdown Current decline from peak	-26.42%	-2.48%	-23.94%
Average Drawdown Average peak-to-trough decline	-36.76%	-51.59%	+14.83%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.82%	8.38%	+2.44%

Volatility

SUPN vs. DFTX - Volatility Comparison

The current volatility for Supernus Pharmaceuticals, Inc. (SUPN) is 10.31%, while Definium Therapeutics, Inc (DFTX) has a volatility of 15.93%. This indicates that SUPN experiences smaller price fluctuations and is considered to be less risky than DFTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SUPN	DFTX	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.31%	15.93%	-5.62%
Volatility (6M) Calculated over the trailing 6-month period	22.30%	38.84%	-16.54%
Volatility (1Y) Calculated over the trailing 1-year period	36.17%	61.78%	-25.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	35.23%	84.08%	-48.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	43.85%	84.08%	-40.23%

Dividends

SUPN vs. DFTX - Dividend Comparison

Neither SUPN nor DFTX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both SUPN and DFTX in my portfolio?

SUPN and DFTX have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SUPN or DFTX?

DFTX has higher volatility (15.93%) compared to SUPN (10.31%). In terms of maximum drawdown, SUPN dropped -75.86% vs DFTX's -86.01%.

Which has better risk-adjusted returns?

DFTX currently has the higher Sharpe Ratio (3.37 vs 1.02), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.