SPRY vs. TEM

Last updated Apr 1, 2026

Compare and contrast key facts about Silverback Therapeutics Inc (SPRY) and Tempus AI, Inc (TEM).

Performance

SPRY vs. TEM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Silverback Therapeutics Inc (SPRY) and Tempus AI, Inc (TEM). The values are adjusted to include any dividend payments, if applicable.

SPRY vs. TEM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
SPRY Silverback Therapeutics Inc	-31.07%	10.43%	21.82%
TEM Tempus AI, Inc	-23.42%	74.91%	-16.12%

Fundamentals

Market Cap SPRY : $791.49M TEM : $7.88B
EPS SPRY : -$1.74 TEM : -$1.41
PS Ratio SPRY : 9.39 TEM : 6.19
PB Ratio SPRY : 6.93 TEM : 16.04
Total Revenue (TTM) SPRY : $84.28M TEM : $1.27B
Gross Profit (TTM) SPRY : $45.85M TEM : $885.69M
EBITDA (TTM) SPRY : -$175.98M TEM : $105.31M

Returns By Period

In the year-to-date period, SPRY achieves a -31.07% return, which is significantly lower than TEM's -23.42% return.

SPRY

• 1D: 2.75%
• 1M: -13.47%
• YTD: -31.07%
• 6M: -20.10%
• 1Y: -36.17%
• 3Y*: 7.25%
• 5Y*: -28.93%
• 10Y*: —

TEM

• 1D: 6.73%
• 1M: -15.08%
• YTD: -23.42%
• 6M: -43.97%
• 1Y: -6.26%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

SPRY vs. TEM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SPRY

SPRY Risk / Return Rank: 21
SPRY Sharpe Ratio Rank: 17
SPRY Sortino Ratio Rank: 19
SPRY Omega Ratio Rank: 20
SPRY Calmar Ratio Rank: 23
SPRY Martin Ratio Rank: 24

TEM

TEM Risk / Return Rank: 39
TEM Sharpe Ratio Rank: 38
TEM Sortino Ratio Rank: 41
TEM Omega Ratio Rank: 39
TEM Calmar Ratio Rank: 39
TEM Martin Ratio Rank: 39

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SPRY vs. TEM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Silverback Therapeutics Inc (SPRY) and Tempus AI, Inc (TEM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SPRY	TEM	Difference
Sharpe ratio Return per unit of total volatility	-0.54	-0.08	-0.46
Sortino ratio Return per unit of downside risk	-0.50	0.43	-0.93
Omega ratio Gain probability vs. loss probability	0.94	1.05	-0.10
Calmar ratio Return relative to maximum drawdown	-0.56	-0.09	-0.47
Martin ratio Return relative to average drawdown	-0.97	-0.20	-0.77
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SPRY vs. TEM - Sharpe Ratio Comparison

The current SPRY Sharpe Ratio is -0.54, which is lower than the TEM Sharpe Ratio of -0.08. The chart below compares the historical Sharpe Ratios of SPRY and TEM, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	SPRY	TEM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.54	-0.08	-0.46
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.36	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.24	0.07	-0.30

Correlation

The correlation between SPRY and TEM is 0.27, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

SPRY vs. TEM - Dividend Comparison

Neither SPRY nor TEM has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

SPRY vs. TEM - Drawdown Comparison

The maximum SPRY drawdown since its inception was -95.20%, which is greater than TEM's maximum drawdown of -58.99%. Use the drawdown chart below to compare losses from any high point for SPRY and TEM.

Drawdown Indicators

	SPRY	TEM	Difference
Max Drawdown Largest peak-to-trough decline	-95.20%	-58.99%	-36.21%
Max Drawdown (1Y) Largest decline over 1 year	-63.32%	-58.96%	-4.36%
Max Drawdown (5Y) Largest decline over 5 years	-93.45%	—	—
Current Drawdown Current decline from peak	-86.71%	-56.20%	-30.51%
Average Drawdown Average peak-to-trough decline	-77.98%	-29.79%	-48.19%
Ulcer Index Depth and duration of drawdowns from previous peaks	36.73%	27.36%	+9.37%

Volatility

SPRY vs. TEM - Volatility Comparison

Silverback Therapeutics Inc (SPRY) has a higher volatility of 17.65% compared to Tempus AI, Inc (TEM) at 15.92%. This indicates that SPRY's price experiences larger fluctuations and is considered to be riskier than TEM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SPRY	TEM	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.65%	15.92%	+1.73%
Volatility (6M) Calculated over the trailing 6-month period	51.95%	42.52%	+9.43%
Volatility (1Y) Calculated over the trailing 1-year period	67.04%	74.58%	-7.54%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	80.53%	100.71%	-20.18%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	81.43%	100.71%	-19.28%

Financials