SPRX vs. SPRO

Last updated Apr 1, 2026

Compare and contrast key facts about Spear Alpha ETF (SPRX) and Spero Therapeutics, Inc. (SPRO).

SPRX is an actively managed fund by Spear. It was launched on Aug 3, 2021.

Performance

SPRX vs. SPRO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Spear Alpha ETF (SPRX) and Spero Therapeutics, Inc. (SPRO). The values are adjusted to include any dividend payments, if applicable.

SPRX vs. SPRO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
SPRX Spear Alpha ETF	-7.54%	41.91%	20.58%	88.02%	-44.99%	8.91%
SPRO Spero Therapeutics, Inc.	0.43%	126.21%	-29.93%	-15.03%	-89.19%	17.12%

Returns By Period

In the year-to-date period, SPRX achieves a -7.54% return, which is significantly lower than SPRO's 0.43% return.

SPRX

• 1D: 7.41%
• 1M: -8.64%
• YTD: -7.54%
• 6M: -7.61%
• 1Y: 79.51%
• 3Y*: 33.34%
• 5Y*: —
• 10Y*: —

SPRO

• 1D: 4.46%
• 1M: 7.83%
• YTD: 0.43%
• 6M: 24.47%
• 1Y: 225.00%
• 3Y*: 17.30%
• 5Y*: -30.35%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

SPRX vs. SPRO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SPRX

SPRX Risk / Return Rank: 86
SPRX Sharpe Ratio Rank: 85
SPRX Sortino Ratio Rank: 85
SPRX Omega Ratio Rank: 79
SPRX Calmar Ratio Rank: 91
SPRX Martin Ratio Rank: 87

SPRO

SPRO Risk / Return Rank: 90
SPRO Sharpe Ratio Rank: 72
SPRO Sortino Ratio Rank: 99
SPRO Omega Ratio Rank: 98
SPRO Calmar Ratio Rank: 94
SPRO Martin Ratio Rank: 87

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SPRX vs. SPRO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Spear Alpha ETF (SPRX) and Spero Therapeutics, Inc. (SPRO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SPRX	SPRO	Difference
Sharpe ratio Return per unit of total volatility	1.68	0.90	+0.78
Sortino ratio Return per unit of downside risk	2.23	6.29	-4.06
Omega ratio Gain probability vs. loss probability	1.30	1.78	-0.49
Calmar ratio Return relative to maximum drawdown	3.15	5.16	-2.01
Martin ratio Return relative to average drawdown	10.00	9.02	+0.99
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SPRX vs. SPRO - Sharpe Ratio Comparison

The current SPRX Sharpe Ratio is 1.68, which is higher than the SPRO Sharpe Ratio of 0.90. The chart below compares the historical Sharpe Ratios of SPRX and SPRO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	SPRX	SPRO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.68	0.90	+0.78
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.20	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.32	-0.14	+0.46

Correlation

The correlation between SPRX and SPRO is 0.26, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

SPRX vs. SPRO - Dividend Comparison

Neither SPRX nor SPRO has paid dividends to shareholders.

	TTM	2025	2024	2023	2022	2021
SPRX Spear Alpha ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.25%
SPRO Spero Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Drawdowns

SPRX vs. SPRO - Drawdown Comparison

The maximum SPRX drawdown since its inception was -51.21%, smaller than the maximum SPRO drawdown of -97.46%. Use the drawdown chart below to compare losses from any high point for SPRX and SPRO.

Drawdown Indicators

	SPRX	SPRO	Difference
Max Drawdown Largest peak-to-trough decline	-51.21%	-97.46%	+46.25%
Max Drawdown (1Y) Largest decline over 1 year	-24.21%	-39.80%	+15.59%
Max Drawdown (5Y) Largest decline over 5 years	—	-97.13%	—
Current Drawdown Current decline from peak	-18.60%	-89.40%	+70.80%
Average Drawdown Average peak-to-trough decline	-18.18%	-61.75%	+43.57%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.63%	22.77%	-15.14%

Volatility

SPRX vs. SPRO - Volatility Comparison

Spear Alpha ETF (SPRX) has a higher volatility of 18.19% compared to Spero Therapeutics, Inc. (SPRO) at 13.13%. This indicates that SPRX's price experiences larger fluctuations and is considered to be riskier than SPRO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SPRX	SPRO	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.19%	13.13%	+5.06%
Volatility (6M) Calculated over the trailing 6-month period	35.60%	32.66%	+2.94%
Volatility (1Y) Calculated over the trailing 1-year period	47.73%	252.14%	-204.41%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	41.58%	151.63%	-110.05%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	41.58%	125.84%	-84.26%