SCLX vs. AMGN

Last updated Aug 1, 2026

SCLX (Scilex Holding Company) and AMGN (Amgen Inc.) are both stocks. Both operate in the Drug Manufacturers - General industry within the Healthcare sector. Over the past 5 years, SCLX returned -50.18%/yr vs 13.29%/yr for AMGN. Their 0.07 correlation means their historical movements had little consistent relationship.

Performance

SCLX vs. AMGN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Scilex Holding Company (SCLX) and Amgen Inc. (AMGN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SCLX achieves a -12.26% return, which is significantly lower than AMGN's 19.38% return.

SCLX

• 1D: 0.98%
• 1M: -14.66%
• 6M: 25.63%
• YTD: -12.26%
• 1Y: -20.18%
• 3Y*: -61.16%
• 5Y*: -50.18%
• 10Y*: —
• ALL TIME*: -47.40%

AMGN

• 1D: -0.64%
• 1M: 2.94%
• 6M: 14.30%
• YTD: 19.38%
• 1Y: 33.64%
• 3Y*: 22.08%
• 5Y*: 13.29%
• 10Y*: 11.54%
• ALL TIME*: 22.83%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
AMGN Amgen Inc.	$985.57M	$876.84M	$944.78M
SCLX Scilex Holding Company	$729.88K	$1.72M	$1.09M

SCLX vs. AMGN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
SCLX Scilex Holding Company	-12.26%	-18.25%	-79.10%	-48.87%	-60.26%	1.93%
AMGN Amgen Inc.	19.38%	29.67%	-6.77%	13.46%	20.43%	3.74%

Correlation

The correlation between SCLX and AMGN is 0.09, meaning there was essentially no consistent relationship between their historical price movements. Each responded to its own set of market drivers.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.09
Correlation (3Y) Balances recent behavior with more history.	0.08
Correlation (5Y) Shows whether the relationship held over a longer period.	0.07
Correlation (All Time) Calculated using the full available price history since Mar 5, 2021	0.07

Fundamentals

Market Cap SCLX : $56.59M AMGN : $207.87B
EPS SCLX : -$35.56 AMGN : $14.36
PS Ratio SCLX : 2.49 AMGN : 5.62
Total Revenue (TTM) SCLX : $30.25M AMGN : $37.24B
Gross Profit (TTM) SCLX : $18.07M AMGN : $26.61B
EBITDA (TTM) SCLX : -$352.83M AMGN : $17.27B

Return for Risk

SCLX vs. AMGN — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

SCLX

SCLX Risk / Return Rank: 41
SCLX Sharpe Ratio Rank: 36
SCLX Sortino Ratio Rank: 48
SCLX Omega Ratio Rank: 46
SCLX Calmar Ratio Rank: 36
SCLX Martin Ratio Rank: 38

AMGN

AMGN Risk / Return Rank: 80
AMGN Sharpe Ratio Rank: 81
AMGN Sortino Ratio Rank: 80
AMGN Omega Ratio Rank: 78
AMGN Calmar Ratio Rank: 80
AMGN Martin Ratio Rank: 79

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

SCLX vs. AMGN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Scilex Holding Company (SCLX) and Amgen Inc. (AMGN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SCLX	AMGN	Difference
Sharpe ratio: Return per unit of total volatility	-0.18	1.27	-1.45
Sortino ratio: Return per unit of downside risk	0.58	2.05	-1.47
Omega ratio: Gain probability vs. loss probability	1.07	1.25	-0.18
Calmar ratio: Return relative to maximum drawdown	-0.25	2.09	-2.34
Martin ratio: Return relative to average drawdown	-0.35	4.86	-5.21

SCLX vs. AMGN - Sharpe Ratio Comparison

The current SCLX Sharpe Ratio is -0.18, which is lower than the AMGN Sharpe Ratio of 1.27. The chart below compares the historical Sharpe Ratios of SCLX and AMGN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SCLX vs. AMGN - Drawdown Comparison

The maximum SCLX drawdown since its inception was -99.23%, which is greater than AMGN's maximum drawdown of -63.48%. Use the drawdown chart below to compare losses from any high point for SCLX and AMGN.

Drawdown Indicators

	SCLX	AMGN	Difference
Max Drawdown Largest peak-to-trough decline	-99.23%	-63.48%	-35.75%
Max Drawdown (1Y) Largest decline over 1 year	-80.27%	-16.57%	-63.70%
Max Drawdown (3Y) Largest decline over 3 years	-98.19%	-22.74%	-75.45%
Max Drawdown (5Y) Largest decline over 5 years	-99.23%	-24.86%	-74.37%
Max Drawdown (10Y) Largest decline over 10 years	—	-24.86%	—
Current Drawdown Current decline from peak	-97.93%	-2.02%	-95.91%
Average Drawdown Average peak-to-trough decline	-57.92%	-16.74%	-41.18%
Ulcer Index Depth and duration of drawdowns from previous peaks	57.55%	7.11%	+50.44%

Volatility

SCLX vs. AMGN - Volatility Comparison

Scilex Holding Company (SCLX) has a higher volatility of 31.96% compared to Amgen Inc. (AMGN) at 7.99%. This indicates that SCLX's price experiences larger fluctuations and is considered to be riskier than AMGN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SCLX	AMGN	Difference
Volatility (1M) Calculated over the trailing 1-month period	31.96%	7.99%	+23.97%
Volatility (6M) Calculated over the trailing 6-month period	77.60%	19.32%	+58.28%
Volatility (1Y) Calculated over the trailing 1-year period	114.80%	27.34%	+87.46%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	113.52%	24.25%	+89.27%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	109.13%	24.92%	+84.21%

Dividends

SCLX vs. AMGN - Dividend Comparison

SCLX has not paid dividends to shareholders, while AMGN's dividend yield for the trailing twelve months is around 2.54%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AMGN Amgen Inc.	2.54%	2.91%	3.45%	2.96%	2.95%	3.13%	2.78%	2.41%	2.71%	2.65%	2.74%	1.95%
SCLX Scilex Holding Company	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both SCLX and AMGN in my portfolio?

SCLX and AMGN have a correlation of 0.09, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SCLX or AMGN?

SCLX has higher volatility (31.96%) compared to AMGN (7.99%). In terms of maximum drawdown, SCLX dropped -99.23% vs AMGN's -63.48%.

Which has better risk-adjusted returns?

AMGN currently has the higher Sharpe Ratio (1.27 vs -0.18), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.