SBIO.L vs. ESIH.L

Last updated Jun 26, 2026

SBIO.L (Invesco Nasdaq Biotech UCITS ETF) and ESIH.L (iShares MSCI Europe Health Care Sector UCITS ETF) are both Health & Biotech Equities funds - SBIO.L tracks the NASDAQ Biotechnology TR USD while ESIH.L tracks the MSCI World/Health Care NR USD. Both are passively managed. Over the past 5 years, SBIO.L returned 5.01%/yr vs 4.92%/yr for ESIH.L. A 0.54 correlation means they provide meaningful diversification when combined. SBIO.L charges 0.40%/yr vs 0.18%/yr for ESIH.L.

Performance

SBIO.L vs. ESIH.L - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Invesco Nasdaq Biotech UCITS ETF (SBIO.L) and iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

SBIO.L is traded in USD, while ESIH.L is traded in GBP. To make them comparable, the ESIH.L values have been converted to USD using the latest available exchange rates.

Returns By Period

In the year-to-date period, SBIO.L achieves a 12.10% return, which is significantly higher than ESIH.L's 0.43% return.

SBIO.L

• 1D: 1.11%
• 1M: 8.11%
• YTD: 12.10%
• 6M: 10.11%
• 1Y: 51.92%
• 3Y*: 16.41%
• 5Y*: 5.01%
• 10Y*: 9.97%

ESIH.L

• 1D: 1.65%
• 1M: 1.82%
• YTD: 0.43%
• 6M: -0.39%
• 1Y: 13.42%
• 3Y*: 7.16%
• 5Y*: 4.92%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

SBIO.L vs. ESIH.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
SBIO.L Invesco Nasdaq Biotech UCITS ETF	12.10%	32.89%	-2.00%	6.15%	-11.85%	-0.49%	8.02%
ESIH.L iShares MSCI Europe Health Care Sector UCITS ETF	0.43%	21.28%	-2.20%	11.03%	-9.30%	16.03%	-8.10%

Correlation

The correlation between SBIO.L and ESIH.L is 0.61, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.61
Correlation (3Y) Calculated over the trailing 3-year period	0.54
Correlation (5Y) Calculated over the trailing 5-year period	0.54
Correlation (All Time) Calculated using the full available price history since Nov 17, 2020	0.54

The correlation between SBIO.L and ESIH.L has been stable across timeframes, ranging from 0.54 to 0.61 - a consistent structural relationship.

SBIO.L vs. ESIH.L - Sectors Allocation Comparison

Sectors	SBIO.L	ESIH.L
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

SBIO.L vs. ESIH.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SBIO.L

SBIO.L Risk / Return Rank: 89
SBIO.L Sharpe Ratio Rank: 89
SBIO.L Sortino Ratio Rank: 89
SBIO.L Omega Ratio Rank: 80
SBIO.L Calmar Ratio Rank: 95
SBIO.L Martin Ratio Rank: 93

ESIH.L

ESIH.L Risk / Return Rank: 28
ESIH.L Sharpe Ratio Rank: 30
ESIH.L Sortino Ratio Rank: 31
ESIH.L Omega Ratio Rank: 29
ESIH.L Calmar Ratio Rank: 27
ESIH.L Martin Ratio Rank: 24

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SBIO.L vs. ESIH.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Invesco Nasdaq Biotech UCITS ETF (SBIO.L) and iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	SBIO.L	ESIH.L	Difference
Sharpe ratio: Return per unit of total volatility	2.58	0.73	+1.85
Sortino ratio: Return per unit of downside risk	3.57	1.16	+2.42
Omega ratio: Gain probability vs. loss probability	1.41	1.14	+0.27
Calmar ratio: Return relative to maximum drawdown	6.76	0.90	+5.86
Martin ratio: Return relative to average drawdown	20.42	2.01	+18.42

SBIO.L vs. ESIH.L - Sharpe Ratio Comparison

The current SBIO.L Sharpe Ratio is 2.58, which is higher than the ESIH.L Sharpe Ratio of 0.73. The chart below compares the historical Sharpe Ratios of SBIO.L and ESIH.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

SBIO.L vs. ESIH.L - Drawdown Comparison

The maximum SBIO.L drawdown since its inception was -39.44%, which is greater than ESIH.L's maximum drawdown of -29.18%. Use the drawdown chart below to compare losses from any high point for SBIO.L and ESIH.L.

Drawdown Indicators

	SBIO.L	ESIH.L	Difference
Max Drawdown Largest peak-to-trough decline	-39.44%	-29.18%	-10.26%
Max Drawdown (1Y) Largest decline over 1 year	-7.65%	-14.92%	+7.27%
Max Drawdown (3Y) Largest decline over 3 years	-26.89%	-26.24%	-0.65%
Max Drawdown (5Y) Largest decline over 5 years	-38.33%	-29.18%	-9.15%
Max Drawdown (10Y) Largest decline over 10 years	-38.33%	—	—
Current Drawdown Current decline from peak	0.00%	-8.79%	+8.79%
Average Drawdown Average peak-to-trough decline	-16.75%	-8.72%	-8.03%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.53%	6.67%	-4.14%

Volatility

SBIO.L vs. ESIH.L - Volatility Comparison

Invesco Nasdaq Biotech UCITS ETF (SBIO.L) has a higher volatility of 6.76% compared to iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L) at 6.16%. This indicates that SBIO.L's price experiences larger fluctuations and is considered to be riskier than ESIH.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SBIO.L	ESIH.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.76%	6.16%	+0.60%
Volatility (6M) Calculated over the trailing 6-month period	15.61%	13.70%	+1.91%
Volatility (1Y) Calculated over the trailing 1-year period	20.04%	18.33%	+1.71%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.21%	19.28%	+1.93%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.20%	19.35%	+2.85%

SBIO.L vs. ESIH.L - Expense Ratio Comparison

SBIO.L has a 0.40% expense ratio, which is higher than ESIH.L's 0.18% expense ratio.

Dividends

SBIO.L vs. ESIH.L - Dividend Comparison

Neither SBIO.L nor ESIH.L has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both SBIO.L and ESIH.L in my portfolio?

SBIO.L and ESIH.L have a correlation of 0.61, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, SBIO.L or ESIH.L?

On fees, ESIH.L is cheaper at 0.18% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, SBIO.L or ESIH.L?

ESIH.L is cheaper with a 0.18% expense ratio, compared with 0.40% for SBIO.L.

What is the main difference between SBIO.L and ESIH.L?

SBIO.L tracks NASDAQ Biotechnology TR USD, while ESIH.L tracks MSCI World/Health Care NR USD. They also come from different issuers: Invesco and iShares. Their fees differ too: 0.40% for SBIO.L and 0.18% for ESIH.L.