RYOIX vs. LYFIX

Last updated Jun 4, 2026

RYOIX (Rydex Biotechnology Fund) and LYFIX (AlphaCentric LifeSci Healthcare Fund) are both Health & Biotech Equities funds. Over the past 5 years, RYOIX returned 4.98%/yr vs 5.20%/yr for LYFIX. Their correlation of 0.84 suggests significant overlap in exposure. RYOIX charges 1.36%/yr vs 1.40%/yr for LYFIX.

Performance

RYOIX vs. LYFIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Rydex Biotechnology Fund (RYOIX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, RYOIX achieves a 3.07% return, which is significantly higher than LYFIX's -0.57% return.

RYOIX

• 1D: -2.50%
• 1M: -0.87%
• YTD: 3.07%
• 6M: 1.44%
• 1Y: 37.64%
• 3Y*: 12.67%
• 5Y*: 4.98%
• 10Y*: 8.43%

LYFIX

• 1D: -3.07%
• 1M: -1.86%
• YTD: -0.57%
• 6M: -1.29%
• 1Y: 33.09%
• 3Y*: 6.91%
• 5Y*: 5.20%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

RYOIX vs. LYFIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
RYOIX Rydex Biotechnology Fund	3.07%	30.62%	-0.95%	6.06%	-13.04%	2.05%	21.94%	4.36%
LYFIX AlphaCentric LifeSci Healthcare Fund	-0.57%	28.22%	-0.27%	7.19%	-0.92%	-3.42%	54.83%	1.20%

Correlation

The correlation between RYOIX and LYFIX is 0.92, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.92
Correlation (3Y) Calculated over the trailing 3-year period	0.85
Correlation (5Y) Calculated over the trailing 5-year period	0.85
Correlation (All Time) Calculated using the full available price history since Dec 2, 2019	0.84

The correlation between RYOIX and LYFIX has been stable across timeframes, ranging from 0.84 to 0.92 - a consistent structural relationship.

Return for Risk

RYOIX vs. LYFIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RYOIX

RYOIX Risk / Return Rank: 62
RYOIX Sharpe Ratio Rank: 47
RYOIX Sortino Ratio Rank: 48
RYOIX Omega Ratio Rank: 40
RYOIX Calmar Ratio Rank: 90
RYOIX Martin Ratio Rank: 86

LYFIX

LYFIX Risk / Return Rank: 55
LYFIX Sharpe Ratio Rank: 41
LYFIX Sortino Ratio Rank: 39
LYFIX Omega Ratio Rank: 35
LYFIX Calmar Ratio Rank: 84
LYFIX Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RYOIX vs. LYFIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Rydex Biotechnology Fund (RYOIX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	RYOIX	LYFIX	Difference
Sharpe ratio: Return per unit of total volatility	2.02	1.86	+0.16
Sortino ratio: Return per unit of downside risk	2.93	2.63	+0.30
Omega ratio: Gain probability vs. loss probability	1.34	1.31	+0.03
Calmar ratio: Return relative to maximum drawdown	4.63	3.95	+0.67
Martin ratio: Return relative to average drawdown	16.65	14.43	+2.21
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

RYOIX vs. LYFIX - Sharpe Ratio Comparison

The current RYOIX Sharpe Ratio is 2.02, which is comparable to the LYFIX Sharpe Ratio of 1.86. The chart below compares the historical Sharpe Ratios of RYOIX and LYFIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	RYOIX	LYFIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.02	1.86	+0.16
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.24	0.23	+0.01
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.36	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.36	0.50	-0.14

Drawdowns

RYOIX vs. LYFIX - Drawdown Comparison

The maximum RYOIX drawdown since its inception was -74.43%, which is greater than LYFIX's maximum drawdown of -35.33%. Use the drawdown chart below to compare losses from any high point for RYOIX and LYFIX.

Drawdown Indicators

	RYOIX	LYFIX	Difference
Max Drawdown Largest peak-to-trough decline	-74.43%	-35.33%	-39.10%
Max Drawdown (1Y) Largest decline over 1 year	-8.43%	-8.49%	+0.06%
Max Drawdown (3Y) Largest decline over 3 years	-23.47%	-24.22%	+0.75%
Max Drawdown (5Y) Largest decline over 5 years	-33.66%	-32.45%	-1.21%
Max Drawdown (10Y) Largest decline over 10 years	-33.66%	—	—
Current Drawdown Current decline from peak	-4.48%	-4.93%	+0.45%
Average Drawdown Average peak-to-trough decline	-27.64%	-9.87%	-17.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.34%	2.32%	+0.02%

Volatility

RYOIX vs. LYFIX - Volatility Comparison

Rydex Biotechnology Fund (RYOIX) and AlphaCentric LifeSci Healthcare Fund (LYFIX) have volatilities of 6.58% and 6.64%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RYOIX	LYFIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.58%	6.64%	-0.06%
Volatility (6M) Calculated over the trailing 6-month period	14.84%	14.56%	+0.28%
Volatility (1Y) Calculated over the trailing 1-year period	19.35%	18.05%	+1.30%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.22%	22.87%	-1.65%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.23%	23.41%	-0.18%

RYOIX vs. LYFIX - Expense Ratio Comparison

RYOIX has a 1.36% expense ratio, which is lower than LYFIX's 1.40% expense ratio.

Dividends

RYOIX vs. LYFIX - Dividend Comparison

RYOIX's dividend yield for the trailing twelve months is around 12.19%, more than LYFIX's 1.79% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
LYFIX AlphaCentric LifeSci Healthcare Fund	1.79%	1.78%	2.24%	2.63%	4.43%	12.88%	2.30%	0.00%	0.00%	0.00%	0.00%	0.00%
RYOIX Rydex Biotechnology Fund	12.19%	12.57%	14.61%	0.00%	1.29%	19.39%	7.28%	8.58%	14.11%	5.38%	0.00%	1.45%

Frequently Asked Questions

Can I hold both RYOIX and LYFIX in my portfolio?

With a correlation of 0.92, RYOIX and LYFIX move almost identically. Holding both adds very little diversification - you're essentially doubling your position in the same market segment. Choosing one is usually more capital-efficient.

Which is riskier, RYOIX or LYFIX?

LYFIX has higher volatility (6.64%) compared to RYOIX (6.58%). In terms of maximum drawdown, RYOIX dropped -74.43% vs LYFIX's -35.33%.

Which has better risk-adjusted returns?

RYOIX currently has the higher Sharpe Ratio (2.02 vs 1.86), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.