RVMD vs. XBI

Last updated Jun 16, 2026

RVMD (Revolution Medicines, Inc.) is a stock, while XBI (SPDR S&P Biotech ETF) is Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index. Over the past 5 years, RVMD returned 35.73%/yr vs 0.52%/yr for XBI. A 0.63 correlation means they provide meaningful diversification when combined.

Performance

RVMD vs. XBI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Revolution Medicines, Inc. (RVMD) and SPDR S&P Biotech ETF (XBI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, RVMD achieves a 100.95% return, which is significantly higher than XBI's 11.87% return.

RVMD

• 1D: 4.02%
• 1M: 9.89%
• YTD: 100.95%
• 6M: 102.61%
• 1Y: 294.33%
• 3Y*: 86.64%
• 5Y*: 35.73%
• 10Y*: —

XBI

• 1D: 1.95%
• 1M: 4.37%
• YTD: 11.87%
• 6M: 11.41%
• 1Y: 63.76%
• 3Y*: 16.08%
• 5Y*: 0.52%
• 10Y*: 9.98%

*Multi-year figures are annualized to reflect compound growth (CAGR)

RVMD vs. XBI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
RVMD Revolution Medicines, Inc.	100.95%	82.10%	52.51%	20.40%	-5.36%	-36.42%	40.34%
XBI SPDR S&P Biotech ETF	11.87%	35.89%	1.01%	7.60%	-25.87%	-20.45%	43.94%

Correlation

The correlation between RVMD and XBI is 0.61, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.61
Correlation (3Y) Calculated over the trailing 3-year period	0.63
Correlation (5Y) Calculated over the trailing 5-year period	0.69
Correlation (All Time) Calculated using the full available price history since Feb 13, 2020	0.63

The correlation between RVMD and XBI has been stable across timeframes, ranging from 0.61 to 0.69 - a consistent structural relationship.

Return for Risk

RVMD vs. XBI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RVMD

RVMD Risk / Return Rank: 98
RVMD Sharpe Ratio Rank: 98
RVMD Sortino Ratio Rank: 99
RVMD Omega Ratio Rank: 98
RVMD Calmar Ratio Rank: 98
RVMD Martin Ratio Rank: 98

XBI

XBI Risk / Return Rank: 86
XBI Sharpe Ratio Rank: 85
XBI Sortino Ratio Rank: 83
XBI Omega Ratio Rank: 74
XBI Calmar Ratio Rank: 94
XBI Martin Ratio Rank: 91

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RVMD vs. XBI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Revolution Medicines, Inc. (RVMD) and SPDR S&P Biotech ETF (XBI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	RVMD	XBI	Difference
Sharpe ratio: Return per unit of total volatility	4.41	2.45	+1.96
Sortino ratio: Return per unit of downside risk	5.59	3.29	+2.30
Omega ratio: Gain probability vs. loss probability	1.78	1.39	+0.39
Calmar ratio: Return relative to maximum drawdown	11.88	6.59	+5.29
Martin ratio: Return relative to average drawdown	28.48	19.47	+9.01

RVMD vs. XBI - Sharpe Ratio Comparison

The current RVMD Sharpe Ratio is 4.41, which is higher than the XBI Sharpe Ratio of 2.45. The chart below compares the historical Sharpe Ratios of RVMD and XBI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

RVMD vs. XBI - Drawdown Comparison

The maximum RVMD drawdown since its inception was -73.29%, which is greater than XBI's maximum drawdown of -63.89%. Use the drawdown chart below to compare losses from any high point for RVMD and XBI.

Drawdown Indicators

	RVMD	XBI	Difference
Max Drawdown Largest peak-to-trough decline	-73.29%	-63.89%	-9.40%
Max Drawdown (1Y) Largest decline over 1 year	-24.95%	-9.72%	-15.23%
Max Drawdown (3Y) Largest decline over 3 years	-48.63%	-32.99%	-15.64%
Max Drawdown (5Y) Largest decline over 5 years	-57.95%	-54.71%	-3.24%
Max Drawdown (10Y) Largest decline over 10 years	—	-63.89%	—
Current Drawdown Current decline from peak	-2.21%	-21.16%	+18.95%
Average Drawdown Average peak-to-trough decline	-35.66%	-20.93%	-14.73%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.57%	3.29%	+7.28%

Volatility

RVMD vs. XBI - Volatility Comparison

Revolution Medicines, Inc. (RVMD) has a higher volatility of 13.97% compared to SPDR S&P Biotech ETF (XBI) at 10.55%. This indicates that RVMD's price experiences larger fluctuations and is considered to be riskier than XBI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RVMD	XBI	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.97%	10.55%	+3.42%
Volatility (6M) Calculated over the trailing 6-month period	55.20%	20.83%	+34.37%
Volatility (1Y) Calculated over the trailing 1-year period	67.30%	26.18%	+41.12%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	62.58%	32.22%	+30.36%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	65.75%	32.03%	+33.72%

Dividends

RVMD vs. XBI - Dividend Comparison

RVMD has not paid dividends to shareholders, while XBI's dividend yield for the trailing twelve months is around 0.32%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
RVMD Revolution Medicines, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.32%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both RVMD and XBI in my portfolio?

RVMD and XBI have a correlation of 0.61, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, RVMD or XBI?

RVMD has higher volatility (13.97%) compared to XBI (10.55%). In terms of maximum drawdown, RVMD dropped -73.29% vs XBI's -63.89%.

Which has better risk-adjusted returns?

RVMD currently has the higher Sharpe Ratio (4.41 vs 2.45), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.