PSTV vs. IOBT

Last updated Apr 1, 2026

Compare and contrast key facts about Plus Therapeutics Inc (PSTV) and IO Biotech, Inc. (IOBT).

Performance

PSTV vs. IOBT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Plus Therapeutics Inc (PSTV) and IO Biotech, Inc. (IOBT). The values are adjusted to include any dividend payments, if applicable.

PSTV vs. IOBT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
PSTV Plus Therapeutics Inc	-68.26%	-55.45%	-34.29%	-63.19%	-69.81%	-42.31%
IOBT IO Biotech, Inc.	-90.36%	-33.82%	-51.06%	-18.26%	-64.06%	-59.11%

Fundamentals

Market Cap PSTV : $12.65B IOBT : $3.93M
EPS PSTV : -$0.00 IOBT : -$1.33
PB Ratio PSTV : 3.17K IOBT : 4.31
Total Revenue (TTM) PSTV : $0.00 IOBT : $0.00
Gross Profit (TTM) PSTV : $0.00 IOBT : -$910.00K
EBITDA (TTM) PSTV : $0.00 IOBT : -$87.26M

Returns By Period

In the year-to-date period, PSTV achieves a -68.26% return, which is significantly higher than IOBT's -90.36% return.

PSTV

• 1D: -24.23%
• 1M: -46.28%
• YTD: -68.26%
• 6M: -76.22%
• 1Y: -82.89%
• 3Y*: -66.56%
• 5Y*: -66.21%
• 10Y*: -69.69%

IOBT

• 1D: -65.95%
• 1M: -83.18%
• YTD: -90.36%
• 6M: -83.83%
• 1Y: -94.61%
• 3Y*: -68.48%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PSTV vs. IOBT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PSTV

PSTV Risk / Return Rank: 13
PSTV Sharpe Ratio Rank: 19
PSTV Sortino Ratio Rank: 19
PSTV Omega Ratio Rank: 20
PSTV Calmar Ratio Rank: 0
PSTV Martin Ratio Rank: 8

IOBT

IOBT Risk / Return Rank: 18
IOBT Sharpe Ratio Rank: 22
IOBT Sortino Ratio Rank: 28
IOBT Omega Ratio Rank: 28
IOBT Calmar Ratio Rank: 3
IOBT Martin Ratio Rank: 5

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PSTV vs. IOBT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Plus Therapeutics Inc (PSTV) and IO Biotech, Inc. (IOBT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PSTV	IOBT	Difference
Sharpe ratio Return per unit of total volatility	-0.51	-0.42	-0.09
Sortino ratio Return per unit of downside risk	-0.48	-0.04	-0.44
Omega ratio Gain probability vs. loss probability	0.94	0.99	-0.05
Calmar ratio Return relative to maximum drawdown	-1.02	-0.97	-0.05
Martin ratio Return relative to average drawdown	-1.55	-1.67	+0.12
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PSTV vs. IOBT - Sharpe Ratio Comparison

The current PSTV Sharpe Ratio is -0.51, which is comparable to the IOBT Sharpe Ratio of -0.42. The chart below compares the historical Sharpe Ratios of PSTV and IOBT, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PSTV	IOBT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.51	-0.42	-0.09
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.34	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.38	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.35	-0.53	+0.18

Correlation

The correlation between PSTV and IOBT is 0.10, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PSTV vs. IOBT - Dividend Comparison

Neither PSTV nor IOBT has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

PSTV vs. IOBT - Drawdown Comparison

The maximum PSTV drawdown since its inception was -100.00%, roughly equal to the maximum IOBT drawdown of -99.62%. Use the drawdown chart below to compare losses from any high point for PSTV and IOBT.

Drawdown Indicators

	PSTV	IOBT	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-99.62%	-0.38%
Max Drawdown (1Y) Largest decline over 1 year	-84.06%	-97.55%	+13.49%
Max Drawdown (5Y) Largest decline over 5 years	-99.62%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	—	—
Current Drawdown Current decline from peak	-100.00%	-99.62%	-0.38%
Average Drawdown Average peak-to-trough decline	-79.35%	-84.57%	+5.22%
Ulcer Index Depth and duration of drawdowns from previous peaks	55.56%	56.99%	-1.43%

Volatility

PSTV vs. IOBT - Volatility Comparison

The current volatility for Plus Therapeutics Inc (PSTV) is 34.29%, while IO Biotech, Inc. (IOBT) has a volatility of 109.77%. This indicates that PSTV experiences smaller price fluctuations and is considered to be less risky than IOBT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PSTV	IOBT	Difference
Volatility (1M) Calculated over the trailing 1-month period	34.29%	109.77%	-75.48%
Volatility (6M) Calculated over the trailing 6-month period	83.69%	190.41%	-106.72%
Volatility (1Y) Calculated over the trailing 1-year period	164.00%	227.25%	-63.25%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	197.12%	135.59%	+61.53%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	184.35%	135.59%	+48.76%

Financials