PROK vs. CRBU

Last updated Jun 5, 2026

PROK (ProKidney Corp.) and CRBU (Caribou Biosciences, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, PROK returned -46.57%/yr vs -24.35%/yr for CRBU. At a 0.28 correlation, their price movements are largely independent.

Performance

PROK vs. CRBU - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ProKidney Corp. (PROK) and Caribou Biosciences, Inc. (CRBU). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PROK achieves a -17.41% return, which is significantly lower than CRBU's 29.87% return.

PROK

• 1D: 6.94%
• 1M: -3.65%
• YTD: -17.41%
• 6M: -28.02%
• 1Y: 134.47%
• 3Y*: -46.57%
• 5Y*: —
• 10Y*: —

CRBU

• 1D: 3.25%
• 1M: 6.99%
• YTD: 29.87%
• 6M: 6.44%
• 1Y: 82.74%
• 3Y*: -24.35%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

PROK vs. CRBU - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
PROK ProKidney Corp.	-17.41%	32.54%	-5.06%	-74.05%	-20.51%
CRBU Caribou Biosciences, Inc.	29.87%	0.00%	-72.25%	-8.76%	-6.69%

Correlation

The correlation between PROK and CRBU is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (All Time) Calculated using the full available price history since Jul 13, 2022	0.28

Fundamentals

Market Cap PROK : $262.56B CRBU : $197.95M
EPS PROK : -$0.00 CRBU : -$1.41
PS Ratio PROK : 74.04K CRBU : 22.09
PB Ratio PROK : 997.94 CRBU : 1.94
Total Revenue (TTM) PROK : $889.00K CRBU : $8.81M
Gross Profit (TTM) PROK : -$2.18M CRBU : $7.49M
EBITDA (TTM) PROK : -$112.46M CRBU : -$115.23M

Return for Risk

PROK vs. CRBU — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PROK

PROK Risk / Return Rank: 77
PROK Sharpe Ratio Rank: 51
PROK Sortino Ratio Rank: 99
PROK Omega Ratio Rank: 98
PROK Calmar Ratio Rank: 74
PROK Martin Ratio Rank: 64

CRBU

CRBU Risk / Return Rank: 69
CRBU Sharpe Ratio Rank: 71
CRBU Sortino Ratio Rank: 72
CRBU Omega Ratio Rank: 67
CRBU Calmar Ratio Rank: 70
CRBU Martin Ratio Rank: 66

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PROK vs. CRBU - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ProKidney Corp. (PROK) and Caribou Biosciences, Inc. (CRBU). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PROK	CRBU	Difference
Sharpe ratio: Return per unit of total volatility	0.26	1.00	-0.74
Sortino ratio: Return per unit of downside risk	6.88	1.84	+5.04
Omega ratio: Gain probability vs. loss probability	1.79	1.21	+0.58
Calmar ratio: Return relative to maximum drawdown	1.93	1.63	+0.30
Martin ratio: Return relative to average drawdown	2.55	2.87	-0.33
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PROK vs. CRBU - Sharpe Ratio Comparison

The current PROK Sharpe Ratio is 0.26, which is lower than the CRBU Sharpe Ratio of 1.00. The chart below compares the historical Sharpe Ratios of PROK and CRBU, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PROK	CRBU	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.26	1.00	-0.74
Sharpe Ratio (All Time) Calculated using the full available price history	-0.12	-0.40	+0.29

Drawdowns

PROK vs. CRBU - Drawdown Comparison

The maximum PROK drawdown since its inception was -96.29%, roughly equal to the maximum CRBU drawdown of -97.58%. Use the drawdown chart below to compare losses from any high point for PROK and CRBU.

Drawdown Indicators

	PROK	CRBU	Difference
Max Drawdown Largest peak-to-trough decline	-96.29%	-97.58%	+1.29%
Max Drawdown (1Y) Largest decline over 1 year	-70.08%	-51.06%	-19.02%
Max Drawdown (3Y) Largest decline over 3 years	-96.09%	-91.12%	-4.97%
Current Drawdown Current decline from peak	-86.57%	-93.18%	+6.61%
Average Drawdown Average peak-to-trough decline	-65.10%	-79.28%	+14.18%
Ulcer Index Depth and duration of drawdowns from previous peaks	52.99%	28.89%	+24.10%

Volatility

PROK vs. CRBU - Volatility Comparison

The current volatility for ProKidney Corp. (PROK) is 19.88%, while Caribou Biosciences, Inc. (CRBU) has a volatility of 21.68%. This indicates that PROK experiences smaller price fluctuations and is considered to be less risky than CRBU based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PROK	CRBU	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.88%	21.68%	-1.80%
Volatility (6M) Calculated over the trailing 6-month period	51.38%	49.33%	+2.05%
Volatility (1Y) Calculated over the trailing 1-year period	525.53%	83.40%	+442.13%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	284.71%	86.82%	+197.89%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	284.71%	86.82%	+197.89%

Dividends

PROK vs. CRBU - Dividend Comparison

Neither PROK nor CRBU has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PROK and CRBU in my portfolio?

PROK and CRBU have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PROK or CRBU?

CRBU has higher volatility (21.68%) compared to PROK (19.88%). In terms of maximum drawdown, PROK dropped -96.29% vs CRBU's -97.58%.

Which has better risk-adjusted returns?

CRBU currently has the higher Sharpe Ratio (1.00 vs 0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.