PRLD vs. VT

Last updated Apr 1, 2026

Compare and contrast key facts about Prelude Therapeutics Incorporated (PRLD) and Vanguard Total World Stock ETF (VT).

VT is a passively managed fund by Vanguard that tracks the performance of the FTSE Global All Cap Index. It was launched on Jun 24, 2008.

Performance

PRLD vs. VT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Prelude Therapeutics Incorporated (PRLD) and Vanguard Total World Stock ETF (VT). The values are adjusted to include any dividend payments, if applicable.

PRLD vs. VT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
PRLD Prelude Therapeutics Incorporated	17.93%	127.45%	-70.14%	-29.30%	-51.49%	-82.60%	173.09%
VT Vanguard Total World Stock ETF	-1.71%	22.43%	16.49%	22.02%	-18.00%	18.27%	17.45%

Returns By Period

In the year-to-date period, PRLD achieves a 17.93% return, which is significantly higher than VT's -1.71% return.

PRLD

• 1D: 11.40%
• 1M: 23.91%
• YTD: 17.93%
• 6M: 137.50%
• 1Y: 345.31%
• 3Y*: -15.66%
• 5Y*: -39.23%
• 10Y*: —

VT

• 1D: 3.08%
• 1M: -6.22%
• YTD: -1.71%
• 6M: 1.42%
• 1Y: 21.53%
• 3Y*: 16.86%
• 5Y*: 9.22%
• 10Y*: 11.53%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PRLD vs. VT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PRLD

PRLD Risk / Return Rank: 91
PRLD Sharpe Ratio Rank: 88
PRLD Sortino Ratio Rank: 94
PRLD Omega Ratio Rank: 94
PRLD Calmar Ratio Rank: 93
PRLD Martin Ratio Rank: 89

VT

VT Risk / Return Rank: 77
VT Sharpe Ratio Rank: 74
VT Sortino Ratio Rank: 76
VT Omega Ratio Rank: 77
VT Calmar Ratio Rank: 75
VT Martin Ratio Rank: 82

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PRLD vs. VT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Prelude Therapeutics Incorporated (PRLD) and Vanguard Total World Stock ETF (VT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PRLD	VT	Difference
Sharpe ratio Return per unit of total volatility	1.77	1.25	+0.51
Sortino ratio Return per unit of downside risk	3.37	1.84	+1.52
Omega ratio Gain probability vs. loss probability	1.47	1.27	+0.19
Calmar ratio Return relative to maximum drawdown	4.67	1.83	+2.84
Martin ratio Return relative to average drawdown	10.24	8.51	+1.73
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PRLD vs. VT - Sharpe Ratio Comparison

The current PRLD Sharpe Ratio is 1.77, which is higher than the VT Sharpe Ratio of 1.25. The chart below compares the historical Sharpe Ratios of PRLD and VT, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PRLD	VT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.77	1.25	+0.51
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.32	0.58	-0.90
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.67	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.25	0.40	-0.65

Correlation

The correlation between PRLD and VT is 0.30, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PRLD vs. VT - Dividend Comparison

PRLD has not paid dividends to shareholders, while VT's dividend yield for the trailing twelve months is around 1.82%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PRLD Prelude Therapeutics Incorporated	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VT Vanguard Total World Stock ETF	1.82%	1.82%	1.95%	2.08%	2.20%	1.82%	1.66%	2.32%	2.53%	2.11%	2.39%	2.45%

Drawdowns

PRLD vs. VT - Drawdown Comparison

The maximum PRLD drawdown since its inception was -99.33%, which is greater than VT's maximum drawdown of -50.27%. Use the drawdown chart below to compare losses from any high point for PRLD and VT.

Drawdown Indicators

	PRLD	VT	Difference
Max Drawdown Largest peak-to-trough decline	-99.33%	-50.27%	-49.06%
Max Drawdown (1Y) Largest decline over 1 year	-70.10%	-11.84%	-58.26%
Max Drawdown (5Y) Largest decline over 5 years	-98.62%	-26.38%	-72.24%
Max Drawdown (10Y) Largest decline over 10 years	—	-34.24%	—
Current Drawdown Current decline from peak	-96.27%	-6.89%	-89.38%
Average Drawdown Average peak-to-trough decline	-84.85%	-7.08%	-77.77%
Ulcer Index Depth and duration of drawdowns from previous peaks	32.01%	2.55%	+29.46%

Volatility

PRLD vs. VT - Volatility Comparison

Prelude Therapeutics Incorporated (PRLD) has a higher volatility of 31.39% compared to Vanguard Total World Stock ETF (VT) at 6.33%. This indicates that PRLD's price experiences larger fluctuations and is considered to be riskier than VT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRLD	VT	Difference
Volatility (1M) Calculated over the trailing 1-month period	31.39%	6.33%	+25.06%
Volatility (6M) Calculated over the trailing 6-month period	152.44%	9.95%	+142.49%
Volatility (1Y) Calculated over the trailing 1-year period	196.97%	17.24%	+179.73%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	124.27%	15.98%	+108.29%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	122.12%	17.20%	+104.92%