PRHSX vs. FBTIX

Last updated Aug 1, 2026

PRHSX (T. Rowe Price Health Sciences Fund) and FBTIX (Fidelity Advisor Biotechnology Fund I Class) are both Health & Biotech Equities funds. Over the past 10 years, PRHSX returned 11.23%/yr vs 13.06%/yr for FBTIX. Their correlation of 0.89 means they have usually moved in the same direction. PRHSX charges 0.83%/yr vs 0.73%/yr for FBTIX.

Performance

PRHSX vs. FBTIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in T. Rowe Price Health Sciences Fund (PRHSX) and Fidelity Advisor Biotechnology Fund I Class (FBTIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PRHSX achieves a 8.63% return, which is significantly lower than FBTIX's 23.73% return. Over the past 10 years, PRHSX has underperformed FBTIX with an annualized return of 11.23%, while FBTIX has yielded a comparatively higher 13.06% annualized return.

PRHSX

• 1D: -0.35%
• 1M: -1.27%
• 6M: 9.71%
• YTD: 8.63%
• 1Y: 33.31%
• 3Y*: 9.96%
• 5Y*: 3.65%
• 10Y*: 11.23%
• ALL TIME*: 13.18%

FBTIX

• 1D: 0.67%
• 1M: 0.16%
• 6M: 22.02%
• YTD: 23.73%
• 1Y: 65.42%
• 3Y*: 26.00%
• 5Y*: 13.53%
• 10Y*: 13.06%
• ALL TIME*: 9.19%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
FBTIX Fidelity Advisor Biotechnology Fund I Class	$0.00	$0.00	$0.00
PRHSX T. Rowe Price Health Sciences Fund	$0.00	$0.00	$0.00

PRHSX vs. FBTIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PRHSX T. Rowe Price Health Sciences Fund	8.63%	17.75%	1.82%	3.03%	-12.22%	13.50%	30.19%	37.88%	1.08%	28.04%
FBTIX Fidelity Advisor Biotechnology Fund I Class	23.73%	39.91%	5.63%	11.02%	-7.74%	-2.86%	32.53%	26.11%	-3.61%	26.15%

Correlation

The correlation between PRHSX and FBTIX is 0.81, meaning they have usually moved in the same direction, including during past declines.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.81
Correlation (3Y) Balances recent behavior with more history.	0.81
Correlation (5Y) Shows whether the relationship held over a longer period.	0.81
Correlation (10Y) Provides a long-term view across more market conditions.	0.86
Correlation (All Time) Calculated using the full available price history since Dec 27, 2000	0.89

The correlation between PRHSX and FBTIX has been stable across timeframes, ranging from 0.81 to 0.89 - a consistent structural relationship.

Return for Risk

PRHSX vs. FBTIX — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

PRHSX

PRHSX Risk / Return Rank: 74
PRHSX Sharpe Ratio Rank: 83
PRHSX Sortino Ratio Rank: 82
PRHSX Omega Ratio Rank: 77
PRHSX Calmar Ratio Rank: 78
PRHSX Martin Ratio Rank: 53

FBTIX

FBTIX Risk / Return Rank: 95
FBTIX Sharpe Ratio Rank: 98
FBTIX Sortino Ratio Rank: 94
FBTIX Omega Ratio Rank: 88
FBTIX Calmar Ratio Rank: 98
FBTIX Martin Ratio Rank: 97

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

PRHSX vs. FBTIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for T. Rowe Price Health Sciences Fund (PRHSX) and Fidelity Advisor Biotechnology Fund I Class (FBTIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PRHSX	FBTIX	Difference
Sharpe ratio: Return per unit of total volatility	1.96	2.94	-0.98
Sortino ratio: Return per unit of downside risk	2.87	3.83	-0.97
Omega ratio: Gain probability vs. loss probability	1.33	1.46	-0.13
Calmar ratio: Return relative to maximum drawdown	2.50	7.75	-5.25
Martin ratio: Return relative to average drawdown	6.96	20.71	-13.75

PRHSX vs. FBTIX - Sharpe Ratio Comparison

The current PRHSX Sharpe Ratio is 1.96, which is lower than the FBTIX Sharpe Ratio of 2.94. The chart below compares the historical Sharpe Ratios of PRHSX and FBTIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PRHSX vs. FBTIX - Drawdown Comparison

The maximum PRHSX drawdown since its inception was -42.96%, smaller than the maximum FBTIX drawdown of -63.45%. Use the drawdown chart below to compare losses from any high point for PRHSX and FBTIX.

Drawdown Indicators

	PRHSX	FBTIX	Difference
Max Drawdown Largest peak-to-trough decline	-42.96%	-63.45%	+20.49%
Max Drawdown (1Y) Largest decline over 1 year	-12.81%	-8.90%	-3.91%
Max Drawdown (3Y) Largest decline over 3 years	-21.00%	-32.80%	+11.80%
Max Drawdown (5Y) Largest decline over 5 years	-27.61%	-36.41%	+8.80%
Max Drawdown (10Y) Largest decline over 10 years	-28.97%	-38.64%	+9.67%
Current Drawdown Current decline from peak	-2.23%	-2.98%	+0.75%
Average Drawdown Average peak-to-trough decline	-8.71%	-20.50%	+11.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.59%	3.32%	+1.27%

Volatility

PRHSX vs. FBTIX - Volatility Comparison

The current volatility for T. Rowe Price Health Sciences Fund (PRHSX) is 5.14%, while Fidelity Advisor Biotechnology Fund I Class (FBTIX) has a volatility of 6.85%. This indicates that PRHSX experiences smaller price fluctuations and is considered to be less risky than FBTIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRHSX	FBTIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.14%	6.85%	-1.71%
Volatility (6M) Calculated over the trailing 6-month period	12.96%	17.88%	-4.92%
Volatility (1Y) Calculated over the trailing 1-year period	16.35%	23.46%	-7.11%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	17.46%	23.81%	-6.35%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	19.27%	24.39%	-5.12%

PRHSX vs. FBTIX - Expense Ratio Comparison

PRHSX has a 0.83% expense ratio, which is higher than FBTIX's 0.73% expense ratio.

Dividends

PRHSX vs. FBTIX - Dividend Comparison

PRHSX's dividend yield for the trailing twelve months is around 11.13%, more than FBTIX's 1.12% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FBTIX Fidelity Advisor Biotechnology Fund I Class	1.12%	1.39%	5.69%	1.36%	0.00%	18.74%	8.01%	6.44%	2.35%	0.00%	0.00%	5.23%
PRHSX T. Rowe Price Health Sciences Fund	11.13%	12.09%	12.89%	5.21%	1.77%	7.46%	7.16%	12.29%	6.57%	7.43%	4.55%	11.34%

Frequently Asked Questions

Can I hold both PRHSX and FBTIX in my portfolio?

PRHSX and FBTIX have a correlation of 0.81, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PRHSX or FBTIX?

FBTIX has higher volatility (6.85%) compared to PRHSX (5.14%). In terms of maximum drawdown, PRHSX dropped -42.96% vs FBTIX's -63.45%.

Which has better risk-adjusted returns?

FBTIX currently has the higher Sharpe Ratio (2.94 vs 1.96), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.