PRAX vs. KRRO

Last updated Apr 1, 2026

Compare and contrast key facts about Praxis Precision Medicines, Inc. (PRAX) and Frequency Therapeutics Inc (KRRO).

Performance

PRAX vs. KRRO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Praxis Precision Medicines, Inc. (PRAX) and Frequency Therapeutics Inc (KRRO). The values are adjusted to include any dividend payments, if applicable.

PRAX vs. KRRO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
PRAX Praxis Precision Medicines, Inc.	9.31%	282.98%	245.42%	50.67%
KRRO Frequency Therapeutics Inc	41.32%	-78.96%	-20.57%	209.63%

Fundamentals

Market Cap PRAX : $7.25B KRRO : $106.36M
EPS PRAX : -$13.79 KRRO : -$12.48
PB Ratio PRAX : 8.26 KRRO : 2.07
Total Revenue (TTM) PRAX : $0.00 KRRO : $6.39M
Gross Profit (TTM) PRAX : $0.00 KRRO : $5.10M
EBITDA (TTM) PRAX : -$326.20M KRRO : -$117.05M

Returns By Period

In the year-to-date period, PRAX achieves a 9.31% return, which is significantly lower than KRRO's 41.32% return.

PRAX

• 1D: 16.55%
• 1M: -4.32%
• YTD: 9.31%
• 6M: 507.91%
• 1Y: 750.78%
• 3Y*: 198.33%
• 5Y*: -6.98%
• 10Y*: —

KRRO

• 1D: 10.12%
• 1M: -6.68%
• YTD: 41.32%
• 6M: -76.36%
• 1Y: -34.98%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PRAX vs. KRRO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PRAX

PRAX Risk / Return Rank: 99
PRAX Sharpe Ratio Rank: 98
PRAX Sortino Ratio Rank: 99
PRAX Omega Ratio Rank: 99
PRAX Calmar Ratio Rank: 100
PRAX Martin Ratio Rank: 100

KRRO

KRRO Risk / Return Rank: 39
KRRO Sharpe Ratio Rank: 28
KRRO Sortino Ratio Rank: 51
KRRO Omega Ratio Rank: 56
KRRO Calmar Ratio Rank: 29
KRRO Martin Ratio Rank: 31

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PRAX vs. KRRO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Praxis Precision Medicines, Inc. (PRAX) and Frequency Therapeutics Inc (KRRO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PRAX	KRRO	Difference
Sharpe ratio Return per unit of total volatility	3.82	-0.27	+4.09
Sortino ratio Return per unit of downside risk	7.55	0.86	+6.69
Omega ratio Gain probability vs. loss probability	1.92	1.14	+0.78
Calmar ratio Return relative to maximum drawdown	20.19	-0.39	+20.58
Martin ratio Return relative to average drawdown	61.41	-0.65	+62.06
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PRAX vs. KRRO - Sharpe Ratio Comparison

The current PRAX Sharpe Ratio is 3.82, which is higher than the KRRO Sharpe Ratio of -0.27. The chart below compares the historical Sharpe Ratios of PRAX and KRRO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PRAX	KRRO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.82	-0.27	+4.09
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.05	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	-0.09	+0.05

Correlation

The correlation between PRAX and KRRO is 0.24, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PRAX vs. KRRO - Dividend Comparison

Neither PRAX nor KRRO has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

PRAX vs. KRRO - Drawdown Comparison

The maximum PRAX drawdown since its inception was -98.67%, roughly equal to the maximum KRRO drawdown of -94.13%. Use the drawdown chart below to compare losses from any high point for PRAX and KRRO.

Drawdown Indicators

	PRAX	KRRO	Difference
Max Drawdown Largest peak-to-trough decline	-98.67%	-94.13%	-4.54%
Max Drawdown (1Y) Largest decline over 1 year	-36.33%	-89.72%	+53.39%
Max Drawdown (5Y) Largest decline over 5 years	-97.57%	—	—
Current Drawdown Current decline from peak	-64.32%	-87.42%	+23.10%
Average Drawdown Average peak-to-trough decline	-81.22%	-57.12%	-24.10%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.94%	53.61%	-41.67%

Volatility

PRAX vs. KRRO - Volatility Comparison

The current volatility for Praxis Precision Medicines, Inc. (PRAX) is 21.48%, while Frequency Therapeutics Inc (KRRO) has a volatility of 25.17%. This indicates that PRAX experiences smaller price fluctuations and is considered to be less risky than KRRO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRAX	KRRO	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.48%	25.17%	-3.69%
Volatility (6M) Calculated over the trailing 6-month period	118.54%	169.84%	-51.30%
Volatility (1Y) Calculated over the trailing 1-year period	198.37%	129.21%	+69.16%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	128.56%	138.54%	-9.98%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	125.48%	138.54%	-13.06%

Financials